To systematically evaluate the effect of the percutaneous high-frequency electrical stimulation (PHFES) of the Neiguan point for the prevention and treatment of the hypotension of women during cesarean section. Methods: The databases, such as PubMed, Embase, Web of science, Cochrane Library, CNKI, Wanfang Data, VIP and CBM, were searched by computer. The randomized controlled trials (RCTs) on the effect of PHFES of the Neiguan point for the prevention and treatment of the hypotension of the women during cesarean section were included, and the quality of the included literatures was evaluated. The statistical analysis was performed using RevMan5.4 software. Results: 9 RCTs with 826 women were included. Compared with those of the women in the control group, the incidences of the intraoperative hypotension (RR=0.32, 95%CI 0.25-0.42), the vasoconstrictive drugs used (RR=0.34, 95%CI 0.24-0.48), the dizziness (RR=0.22, 95%CI 0.10-0.47), the chest tightness (RR=0.17, 95%CI 0.10-0.30), the dyspnea (RR=0.32, 95%CI 0.18-0.56), the nausea (RR=0.26, 95%CI 0.15-0.46) and the vomiting (RR=0.23, 95%CI 0.09-0.60) of the women in the experimental group were significantly decreased. There was no significant difference in the neonatal Apgar scores (WMD=0.08, 95%CI 0.05-0.20) of the women between the two groups. Conclusion: PHFES of the Neiguan point can significantly reduce the incidence of the rates of the hypotension, dizziness, chest tightness, dyspnea, nausea and vomiting of the women during cesarean section.

2024 Vol. 32　(11):　2468- [Abstract]（ 77 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To analyze the self-efficacy of patients with endometrial polyp (EP) after hysteroscopic surgery, and to study its influencing factors of the self-efficacy of the patients. Methods: The clinical data of 100 patients with EP who received hysteroscopic surgery in the hospital from January 2022 to March 2023 were collected. The postoperative self-efficacy of the patients was analyzed, and the related factors affecting the postoperative self-efficacy of the patients were also analyzed. Results: The average score of the general self-efficacy scale (GSES) of 100 patients was 21.85±4.20 points. There were 35 (35%) patients with low self-efficacy in group A and 65 (35%) patients with high self-efficacy in group B. The proportion of the unmarried or divorced patients, the incidence of the postoperative complications, the scores of Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) of the patients in group A were significantly higher than those of the patients in group B, and the score of social support rating scale (SSRS) of the patients in group A was significantly lower than that of the patients in group B (all P<0.05). Logistic regression analysis showed that the unmarried, the postoperative complications, the HAMA score ≥11.98 points, the HAMD score ≥14.30 points and the SSRS score <28.23 points of the patients with EP were the influencing factors of their postoperative declined self-efficacy (all P<0.05). Conclusion: After hysteroscopic surgery, the self-efficacy of the patients with EP is low. The unmarried, the postoperative complications, the severity of negative emotions and the low social support of the patients with EP are the main factors affecting their postoperative self-efficacy.

2024 Vol. 32　(11):　2483- [Abstract]（ 50 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

2024 Vol. 32　(11):　2493- [Abstract]（ 24 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

2024 Vol. 32　(11):　2503- [Abstract]（ 16 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To observe the clinical effect of Bazhen Yimu capsule combined with Luohua Zizhu granule for treating women after abortion. Methods: A total of 80 women who had undergoing induced abortion were enrolled and were randomly divided into control group and observation group (40 cases in each group) between March 2022 and July 2023. The women in the control group were treated with auricular point pressing by bean combined with Luohua Zizhu granules, while the women in the observation group were treated with Bazhen Yimu capsules combined with Luohua Zizhu granules. The clinical curative effect, the menstruation recovery, the blood supply situation of the uterine artery and the incidence of the postoperative complications of the women were observed and compared between the two groups. Results: The clinical effective rate (92.5%) of the women in the observation group was significantly higher than that (75.0%) of the women in the control group. The duration of the postoperative bleeding, the bleeding volume and the postoperative menstrual recovery time of the women in the observation group were significantly lower than those of the women in the control group, and the first postoperative menstrual volume and the endometrial thickness of the women in the observation group were significantly higher than those of the women in the control group (P<0.05). The values of the uterine artery resistance index (RI), the pulsatility index (PI) and the ratio of end systolic peak to end diastolic peak (S/D) of the women in the observation group were significantly lower than those of the women in the control group (P<0.05). After treatment, the incidence of the complications (7.5%) of the women in the observation group was significantly lower than that (20.0%) of the women in the control group (P<0.05). Conclusion: Bazhen Yimu capsule combined with Luohua Zizhu granule for treating the women after abortion is beneficial to reduce their postoperative vaginal bleeding volume, promote their recovery of endometrial thickness, improve their uterine blood flow status and reduce the incidence of their postoperative intrauterine adhesion. 

2024 Vol. 32　(11):　2514- [Abstract]（ 21 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

2024 Vol. 32　(11):　2522- [Abstract]（ 22 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To investigate the clinical effect of the intravenous anesthesia of propofol combined with sufentanil of patients during hysteroscopic surgery. Methods: The clinical data of 125 patients with hysteroscopic surgery in the hospital from January 2023 to December 2023 were selected. These patients were divided into two groups according to the different anesthesia regimens. 65 patients in the control group were anesthetized with propofol combined with remifentanil, whereas 60 patients in the experimental group were anesthetized with propofol and sufentanil. The values of the intraoperative hemodynamic indexes, such as mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SpO2), the recovery quality, the inflammatory response and the adverse reactions of the patients were compared between groups. Results: There were no significant differences in the values of MAP, HR and SpO2 of the patients before anesthesia (T0) between the two groups (P>0.05). Compared with those of the patients in the two groups at T0, the values of MAP and HR at the time of cervical dilatation (T1), during the surgery (T2) and at the end of the surgery (T3) were significantly lower and the SpO2 value was significantly higher. The values of MAP, HR and SpO2 of the patients in the experimental group at T1, T2 and T3 were significantly higher than those of the patients in the control group (all P<0.05). The recovery time (10.54±1.27min) of the patients in the experimental group was significantly shorter than that (13.25±2.28min) of the patients in the control group. The score of vigilance and sedation scale (4.14±0.52 points) of the patients in the experimental group was significantly higher than that (3.74±0.43 points) of the patients in the control group, and the visual analogue scale score (2.53±0.65 points) of the patients in the experimental group at 1 hour after surgery was significantly lower than that (2.86±0.74 points) in the control group (P<0.05). The levels of C-reactive protein, tumor necrosis factor-α and interleukin-6 of the patients in the two groups after operation had increased significantly, and which (9.86±1.62 mg/ml, 39.81±12.29 pg/ml, and 45.71±15.28 pg/ml) of the patients in the experimental group were significantly lower than those (18.61±7.69 mg/ml, 75.53±25.69 pg/ml and 78.51±23.92 pg/ml) of the patients in the control group (all P<0.05). There was no significant difference in the incidence of the adverse reactions (29.2% vs. 23.3%) of the patients between the two groups (P>0.05). Conclusion: The intravenous anesthesia of propofol combined with sufentanil of the patients during hysteroscopic surgery has significant effect, which can reduce the intraoperative hemodynamic fluctuations, enhance the recovery quality and relieve the postoperative inflammatory response of the patients, and with the good safety.

2024 Vol. 32　(11):　2531- [Abstract]（ 17 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To observe the clinical curative effect of loop electrosurgical excision procedure (LEEP) combined with recombinant human interferon a-2b (rIL-a2b) suppository for treating patients with cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (h-HPV) infection. Methods: From June 2022 to June 2023, the patients with CIN and h-HPV infection were selected and were randomly divided into control group (80 cases) and study group (78 cases) by the random number table method. The patients in the two groups were treated with LEEP surgery, while the patients in the study group were treated with rIL-a2b suppository after LEEP surgery additionally. The clinical efficacy, the perioperative related indicators, the HPV viral load, the complications rate, and the negative conversion rate and the recurrence rate of HPV infection in the 3rd month and the 6th month after surgery of the patients were compared between the two groups. Results: The wound healing time (41.09±4.95d), the vaginal bleeding time (11.43±1.62d) and the vaginal discharge time (13.81±1.56d) of the patients in the study group were significantly shorter than those (44.17±5.63d, 13.81±1.56d and 19.34±5.45d) of the patients in the control group. The total effective rate of the clinical treatment (93.6%) of the patients in the study group was significantly higher than that (81.3%) of the patients in the control group, and the total incidence (5.1%) of postoperative complications, such as the continuous vaginal bleeding, the incision infection, the cervical adhesion and the cervical stenosis of the patients in the study group was significantly lower than that (15.0%) of the patients in the control group. The h-HPV viral load of the patients in the study group in the 3rd month (1.84±0.32 RLU/CO) or in the 6th month (1.15±0.27 RLU/CO) after surgery was significantly lower than that (2.21±0.26 RLU/CO or 2.07±0.45 RLU/CO) of the patients in the control group. The negative conversion rate of h-HPV infection (60.3%) of the patients in the study group was significantly higher than that (41.3%) of the patients in the control group, and the recurrence rate (5.1%) of h-HPV infection of the patients in the study group was significantly lower than that (16.3%) of the patients in the control group (all P<0.05). Conclusion: LEEP combined with rIL-a2b suppository for treating the patients with CIN and h-HPV infection can increase their clinical effect, and which can effectively promote wound healing, improve the HPV clearance rate, reduce the postoperative complications and reduce the risk of recurrence of h-HPV infection of the patients.

2024 Vol. 32　(11):　2540- [Abstract]（ 28 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To explore the efficacy of Dahuang mudan decoction combined with leuprorelin for treating patients with uterine fibroids, and to study its impacts on the serum matrix metalloproteinase-9 (MMP-9) and cyclooxygenase-2 (COX-2) levels of the patients. Methods: From April 2022 to November 2023, 106 patients with uterine fibroids were included and were randomly divided into two groups (53 cases in each group) by random number table method. The patients in the two groups were given treatment of leuprorelin for 3 months, and the patients in the study group received the Dahuang mudan decoction additionally. The changes of the traditional Chinese medicine syndrome scores, the uterine fibroids size, the uterine size, and the levels of estrogen, progesterone, MMP-9, COX-2 and vascular endothelial growth factor (VEGF) of the patients were compared between the two groups. The clinical efficacy and the drug safety of the patients in the two groups were assessed. Results: After treatment, the total effective rate (90.6%) of the patients in the study group was significantly higher than that (73.6%) of the patients in the control group. The scores of TCM syndromes (abdominal pain, increased menstrual volume, prolonged menstrual period, abnormal leucorrhea and dark complexion), the uterine fibroids volume, the uterine volume, and the levels of estrogen, progesterone and serum factors of the patients in the two groups after treatment were significantly lower than those before treatment, and the decreasing amplitude of which of the patients in the study group were significantly more than those of the patients in the control group. The levels of MMP-9 (1.06±0.35μg/ml) and COX-2 (0.19±0.06pg/L) of the patients in the study group were significantly lower than those (1.38±0.46μg/ml and 0.25±0.08pg/L) of the patients in the control group. The incidence of adverse reactions (3.8%) of the patients in the study group was significantly lower than that (15.1%) of the patients in the control group (all P<0.05). Conclusion: Dahuang mudan decoction combined with leuprorelin for treating the patients with uterine fibroids can effectively improve their total effective rate, decrease their traditional Chinese medicine syndrome scores, reduce their uterine fibroids volume and uterine volume, can effectively control the levels of estrogen and progesterone, can decrease their serum MMP-9, COX-2, and VEGF levels, and can reduce their side effect rate.

2024 Vol. 32　(11):　2551- [Abstract]（ 17 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To analyze the influence of the poor mental state of pregnant women during the third trimester of pregnancy on their fetal hypoxia. Methods: A total of 320 pregnant women who received antenatal examination in the hospital from January 2023 to December 2023 were selected as the research objects. The anxiety and depression status of these women were evaluated by questionnaire, self-rated anxiety scale (SAS) and self-rated depression scale (SDS). The differences of anxiety and depression status of the women were compared between group A (the fetuses with anoxia) and group B (the fetuses without anoxia). The correlation between the poor mental state of the pregnant women and their fetal hypoxia was analyzed. Results: The incidences of the anxiety and depression of the women, and the fetal hypoxia were 27.8%, 10.6% and 13.1%, respectively. The scores of SAS (58.65±20.46 points) and SDS (56.29±22.34 points) of the women in group A (42 cases) were significantly higher than those (46.22±15.08 points and 45.37±13.68 points) of the women in group B (278 cases). The incidences of anxiety (59.5%) and depression (45.2%) of the women in group A were significantly higher than those (23.0% and 5.4%) of the women in group B, and the incidences of severe anxiety and severe depression of the women in group A were significantly higher than those of the women in group B (all P<0.05). The placental factors, the umbilical cord factors, the maternal anxiety and depression were all the independent risk factors of the fetal hypoxia (P<0.05), while the maternal factors were not the independent risk factors of the fetal hypoxia (P>0.05). Conclusion: The anxiety and depression of the pregnant women during the third trimester of pregnancy may increase the risk of their fetal hypoxia, which should be paid attention to in clinic.

2024 Vol. 32　(11):　2561- [Abstract]（ 20 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

 To explore the application effect of the multidimensional warming measures for patients during ovarian cyst surgery. Methods: 98 patients who wanted ovarian cyst surgery in the hospital were selected and randomly divided into two groups (49 cases in each group) by the random number table from September 2021 to September 2023. The patients in both groups received standard nursing care and postoperative rapid recovery measures. On this basis, the patients in the control group were given standard warming measures, while the patients in the study group received multidimensional warming measures. The postoperative recovery status, the nasopharyngeal temperature at different time points, the values of pre- and postoperative coagulation function, such as fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and D-dimer (DD), and the incidences of shivering during the awakening period and the postoperative complications of the patients were compared between the two groups. Results: The nasopharyngeal temperature of the patients in the study group at 30 min of the surgery beginning (36.53±0.18℃) and immediately after the surgery (36.50±0.21℃) were significantly higher than those (36.40±0.19℃ and 36.38±0.22℃)  of the patients in the control group. The postoperative recovery time (24.26±5.28 min), the intestinal function recovery time (1.46±0.44d), the extubation time (26.48±5.31min) and the hospitalization time (4.15±1.26d) of the patients in the study group were significantly shorter than those (31.12±5.34min, 2.03±0.51d, 33.85±5.06min and 5.02±1.30d) of the patients in the control group. The values of APTT (24.09±3.29s), PT (11.75±1.03s) and TT (13.51±0.95s) of the patients in the study group at 4 hours after surgery were significantly higher than those (22.25±3.01s, 10.83±1.04s and 12.04±0.98s) of the patients in the control group. The values of FIB (4.25±0.77g/L) and DD (895.62±99.35μg/L) of the patients in the study group at 4 hours after surgery were significantly lower than those (4.82±0.69 g/L and 1028.49±95.06μg/L) of the patients in the control group. The incidence of shivering during the recovery period (20.4%) of the patients in the study group was significantly lower than that (38.8%) of the patients in the control group. The incidence of the postoperative complications (4.1%) of the patients in the control group was significantly lower than that (16.3%) of the patients in the control group (all P<0.05). Conclusion: The multidimensional warming measures for the patients during ovarian cyst surgery can maintain their intraoperative body temperature and stability of coagulation function, reduce their incidence of shivering, decrease their rate of postoperative complications and accelerate their postoperative recovery.

2024 Vol. 32　(11):　2569- [Abstract]（ 18 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To observe the effect of the targeted intervention for preventing the postpartum hemorrhage of women based on the comprehensive cause analysis. Methods: A total of 98 women with the high-risk postpartum hemorrhage were included and were divided into observation group (49 cases) and control group (49 cases) by random number table method from January 2021 to December 2023. The women in the control group had received routine obstetric care intervention, while the women in the observation group had received routine obstetric care intervention combined with the targeted intervention based on the comprehensive cause analysis of postpartum hemorrhage. The incidences of the postpartum hemorrhage, the delivery complications, the neonatal adverse outcomes, the satisfaction rate of maternal intervention, the amount of the vaginal bleeding in postpartum 2 and 24 hours, the scores of the maternal selfefficacy scale (GSES) and state anxiety scale (SAI) before delivery and in postpartum 24 hours, and the Apgar score of the newborns at 1min and 5min after birth of the women in the two groups were analyzed. Results: The incidences of the postpartum hemorrhage (6.1%), the delivery complications (4.1%) and the incidence of adverse neonatal outcomes (2.0%) of the women in the observation group were significantly lower than those (24.5%, 16.3% and 14.3%) of the women in the control group. The maternal intervention satisfaction rate (91.8%) of the women in the observation group was significantly higher than that (71.4%) of the women in the control group. The amount of vaginal bleeding at 2h and 24h after delivery (211.52±5.92 ml and 305.23±7.72 ml) of the women in the observation group were significantly lower than those (252.34±6.23 ml and 368.34±8.23 ml) of the women in the control group. 24 hours after delivery, the scores of SES (27.20±1.43 points) and SAI (38.54±3.05 points) of the women in the observation group were significantly better than those (25.43±1.85 points and 41.24±2.76 points) of the women in the control group. The Apgar scores of the newborns at 1min and 5min after birth (9.25±0.15 points and 9.63±0.09 points) were significantly higher than those (8.96±0.34 points and 9.42±0.11 points) of the newborns in the control group (all P<0.05). Conclusion: Based on the analysis of the comprehensive causes of the postpartum hemorrhage of the women, the targeted intervention for the women has good effect on preventing their postpartum hemorrhage, which can improve the maternal and infants’ outcomes, and with the good satisfaction.

2024 Vol. 32　(11):　2580- [Abstract]（ 21 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To analyze the application effect of the multidisciplinary cooperation model in the continuing puerperium care of primiparas. Methods: 300 healthy primiparas who had gave birth in the hospital from January 2023 to October 2023 were selected and were divided into two groups (150 cases in each group) according to the principle of the voluntary of the primiparas. The primiparas in the control group received the routine health education during extended care outside the hospital, while the primiparas in the observation group received the multidisciplinary cooperation model during extended care outside the hospital. Before intervention and at the end of the fourth week after intervention, the primiparas in both groups were given assessments of the anxiety and depression levels, the family function and the satisfaction. Results: After intervention, the scores of the anxiety (52.7±2.3 points) and depression (51.7±2.1 points) of the primiparas in the observation group were significantly lower than those (63.7±2.8 points and 60.9±2.6 points) of the primiparas in the control group. The scores of the problem solving (12.5±1.9 points), the communication (10.8±1.7 points), the role (12.1±2.0 points), the emotional reaction (11.7±2.1 points), the emotional intervention (10.8±1.3 points) and the behavior control (12.1±1.7 points) in the family function score of the primiparas in the observation group were significantly lower than those (20.8±3.0 points, 18.9±2.6 points, 19.5±2.5 points, 18.7±2.5 points, 20.7±3.4 points and 19.4±3.0 points) of the primiparas in the control group. The satisfaction scores, such as the service attitude (18.5±3.1 points), the professional skills (22.3±3.5 points), the communication effect (20.7±3.2 points) and the nursing effect (21.9±3.7 points) of the primiparas in the observation group were significantly higher than those (11.2±1.4 points, 12.7±1.6 points, 10.3±1.3 points and 11.9±1.7 points) of the primiparas in the control group (all P<0.05). Conclusion: The multidisciplinary cooperation model in the continuing puerperium
care of the primiparas can improve their anxiety and depression, enhance their family function and increase their nursing satisfaction.

2024 Vol. 32　(11):　2589- [Abstract]（ 26 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

2024 Vol. 32　(11):　2598- [Abstract]（ 12 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To explore the predictive value of the ultrasound examination results combined with the body mass index (BMI) and the β-human chorionic gonadotropin (β-hCG) level for the effect of the conservative treatment of patients with tubal pregnancy by methotrexate. Methods: A total of 120 patients with tubal pregnancy treated in the hospital from January 2021 to April 2024 were selected in this study. All these patients were given conservative treatment by methotrexate. The effect of the conservative treatment was counted. The baseline data were compared among the patients with the different curative effect. The influencing factors of the effect of the conservative treatment of the tubal pregnancy of these patients were analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the ultrasound indicators combined with the BMI and the serum β-hCG level of the patients for the effect of their conservative treatment of tubal pregnancy. Results: After conservative treatment of 120 patients, there were 76 cases with the successful treatment (in group A) and 44 cases with the failed treatment (in group B). The BMI, the adnexal mass volume, the β-hCG level and the average blood flow velocity of the patients in group B were significantly higher than those of the patients in group A, and the blood flow resistance index of the patients in group B was significantly lower than that of the patients in group A (all P<0.05). Logistic regression analysis showed that the BMI, the β-hCG level, and the values of the ultrasound indicators, such as the average blood flow velocity, the adnexal mass volume and the resistance index of the patients with tubal pregnancy were the factors affecting their effect of the conservative treatment (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) of the average blood flow velocity, the resistance index, the adnexal mass volume, the BMI or the β-hCG level of the patients for predicting the effect of their conservative treatment of the tubal pregnancy was 0.802, 0.800, 0.754, 0.701 or 0.672, respectively. The AUC of the combined the average blood flow velocity, the resistance index, the adnexal mass volume, the BMI and the β-hCG level of the patients for predicting their effect of their conservative treatment of the tubal pregnancy was 0.960, which had the best predictive value. Conclusion: The BMI, the serum β-hCG level and the ultrasound imaging indexes, such as the average blood flow velocity, the resistance index and adnexal mass volume of the patients with tubal pregnancy can be used to predict their conservative treatment effect by methotrexate, and the combined of which has the highest predictive efficiency, which can provide the references for the formulation and adjustment of the clinical treatment plan for the tubal pregnancy of the patients.

2024 Vol. 32　(11):　2606- [Abstract]（ 11 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To investigate the predictive values of the levels of the serum 25 hydroxyvitamin D ［25(OH)D］ and the insulin growth factor-1 (IGF-1) of pregnant women with gestational diabetes mellitus (GDM), and to study the predictive values of the levels of the serum 25(OH)D and IGF-) of the women for their neonatal hyperbilirubinemia (NHB). Methods: From January 2023 to March 2024, 290 pregnant women with GDM were selected in study group and were divided into group A (88 cases with NHB) and group B (202 cases without NHB) according to whether NHB occurred. 266 healthy pregnant women who gave birth during the same period were selected in control group. Logistic regression was applied to analyze the influencing factors of the NHB occurrence. Receiver operating characteristic (ROC) curve was used to analyze the predictive values of the serum 25(OH)D and IGF-1 levels of the women with GDM for their NHB occurrence. Spearman method was applied to analyze the correlation between the serum 25(OH)D and IGF-1 levels of the women with GDM and their NHB occurrence. Results: The serum levels of 25(OH)D (29.64±3.16 ng/ml) and IGF-1 (38.86±4.17 ng/ml) of the women in the study group were significantly lower than those (34.71±3.82 ng/ml and 45.58±4.69 ng/ml) of the women in the control group. In the study group, the serum levels of 25(OH)D (27.54±2.86 ng/ml) and IGF-1 (35.68±3.81 ng/ml) of the women in group A were significantly lower than those (30.55±3.29 ng/ml and 40.25±4.33 ng/ml) of the women in group B (all P<0.05). The high prenatal fasting blood glucose value, the family history of diabetes, the low neonatal Apgar score at 5min after birth, and the low serum 25(OH)D and IGF-1 levels of the women with GDM were the risk factors of their NHB occurrence (P<0.05). The area under the curve (AUC) of the combination of the 25(OH)D and IGF-1 levels of the women with GDM for predicting their NHB occurrence was 0.878, and which was significantly higher than that (0.784) of the 25(OH)D level or that (0.775) of IGF-1 level alone (P<0.001). The serum levels of 25(OH)D and IGF-1 of the women with GDM were negatively correlated with their NHB occurrence (r=-0.409, -0.421, P<0.05). Conclusion: The serum levels of 25(OH)D and IGF-1 of the women with GDM decrease, and which have certain values for evaluating the NHB occurrence of the women.

2024 Vol. 32　(11):　2615- [Abstract]（ 30 ） HTML (0 KB)  PDF  (0 KB)  ( 7 )

2024 Vol. 32　(11):　2625- [Abstract]（ 17 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To investigate the related factors of the hypoxemia during anesthesia recovery period of patients after laparoscopic total hysterectomy (LTH) under general anesthesia, and to provide the nursing countermeasures of the hypoxemia. Methods: The clinical data of 280 patients with LTH under general anesthesia in hospital from March 2022 to January 2024 were analyzed retrospectively. Logistic regression was used to analyze the influencing factors of the hypoxemia of the patients with LTH during the anesthesia recovery. The regression prediction model was constructed, and the goodness of fit and the predictive efficiency of the model for the hypoxemia of the patients with LTH during the anesthesia recovery was determined. Results: The incidence of the hypoxemia of the patients with LTH during anesthesia recovery was 27.1% (76/280). Univariate analysis showed that there were significant differences in the age, the body mass index (BMI), the classification by American society of anesthesiologists (ASA) rating, the dosage of propofol used, the operation time, and the duration of the postanesthesia care unit (PACU) stay between the patients with hypoxemia and the patients without hypoxemia (P<0.05). Binary logistic regression analysis showed that the age ≥65 years old (OR=1.926, 95%CI 1.073-3.458), the high BMI (OR=1.824, 95%CI 1.485-2.239), the gradeⅢ of ASA (OR=2.353, 95%CI 1.0733.458), the high dosage of propofol used (OR=1.005, 95%CI 1.002-1.008) and the long operation time (OR=1.078, 95%CI 1.050-1.107) of the patients with LTH were the factors influencing their hypoxemia during the anesthesia recovery period (P<0.05). According to these influencing factors, the prediction model was constructed, and the H-L test prediction model had a good goodness of fit. Receiver operating characteristic (ROC) curve showed that the area under the curve, the sensitivity and the specificity of the model for predicting the hypoxemia of the patients with LTH during the anesthesia recovery period were 0.900, 80.3% and 87.3%, respectively. Conclusion: The age ≥65 years old, the high BMI, the grade Ⅲ of ASA, the high dosage of propofol used, and the long operation time of the patients with LTH during the anesthesia recovery period can affect their hypoxemia occurrence, and the prediction model established based on these affecting factors has the good predictive effect for the hypoxemia occurrence of the patients. The clinical prevention and nursing based on the prediction model should be conducted, so as to reduce the risk of the hypoxemia of the patients with LTH during the anesthesia recovery period.

2024 Vol. 32　(11):　2635- [Abstract]（ 23 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To investigate the diagnostic value of chromosome microarray technology (CMA) and low depth whole genome sequencing technology (CNV-seq) for fetal DNA abnormalities, and to study the etiology detections. Methods: 150 pregnant women who underwent labor induction in the hospital from January 2021 to December 2023 were selected as the research objects. The results of the prenatal noninvasive genetic screening (NIPT) technology of the fetal DNA were used as the gold standard. CMA and CNV-seq were detected in all the fetuses after labor induction. The results of these fetuses were compared between CMA and CNV-seq. Receiver characteristic (ROC) curve was used to analyze the diagnostic values of CMA and CNV-seq for the fetal DNA abnormalities. The results of the etiology detection of the fetuses with DNA abnormalities were also compared between CMA and CNV-seq. Results: The positive detection rate of the fetuses with DNA abnormalities by CNV-seq was 85.9%, and which was significantly higher than that (73.7%) by CMA. The area under the curve (AUC) of CNV-seq for diagnosing the fetal DNA abnormalities was 0.870, which was significantly higher than that (0.761) of CMA. The detection rate of the etiology of the fetuses with DNA abnormalities by CNV-seq was 85.9%, and which was significantly higher than that (73.7%) by CMA (all P<0.05). Conclusion: Both CMA and CNV-seq have high detection rates for the fetal DNA abnormalities and also have high detection rates of the etiology of the fetuses with DNA abnormalities, and CNV-seq has the higher diagnostic efficiency than that of CMA, and both CMA and CNV-seq can provide the references for the prenatal diagnosis of the fetal DNA abnormalities.

2024 Vol. 32　(11):　2645- [Abstract]（ 18 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To analyze the risk factors of the hypertensive disorder complicating pregnancy (HDP) of pregnant women based on their indexes of Down's screening and hemorheology. Methods: 80 pregnant women with HDP admitted to the hospital from January 2020 to December 2023 were selected in study group retrospectively, another 76 pregnant women without HDP who had received antenatal examination were selected in control group. The indexes of Down's screening and hemorheology of the women were compared between the two groups. Univariate and logistic multivariate regression analysis were used to analyze the risk factors of HDP of the women. Spearman rank correlation analysis was used to analyze the correlation between the indexes of Down's screening and hemorheology of the pregnant women and their HDP occurrence. Results: There were significant differences in the obesity rate, the history of diabetes, the family history of HDP, the prenatal examination situation, the negative emotions, the values of activated partial prothrombin time (APTT), prothrombin time (PT), thrombin time (TT) and pregnancy-associated plasma protein A (PAPP-A), and the levels of β-human chorionic gonadotropin (β-hCG), free estriol (uE3) and alpha fetoprotein (AFP) the women were compared between the two groups (P<0.05). Multivariate analysis showed that the obesity, the history of diabetes, the family history of HDP, the lack of regular prenatal examination, the negative emotions, the decreased values of APTT, PT, TT, uE3, and PAPP-A, and the increased levels of AFP and β-hCG of the women were the independent risk factors of their HDP occurrence (all P<0.05). Spearman correlation analysis showed that the levels of APTT, PT, TT, uE3 and PAPP-A of the women were negatively correlated with their HDP occurrence (r=-0.438, -0.452, -0.434, 0.478, -0.423, all P<0.05). The levels of AFP and β-hCG of the women were positively correlated with their HDP occurrence (r=0.463, 0.441, all P<0.05). Conclusion: The Down syndrome screening indicators, such as serum uE3, AFP, PAPP-A andβ-hCG, and the hemorheological indicators, such as APTT, PT and TT of the pregnant women are all closely related to their HDP occurrence, and all of which should be paid attention to in clinical prenatal examination, and the corresponding prevention and treatment measures should be conducted to reduce the risk of HDP and to improve the pregnancy outcomes of the women.

2024 Vol. 32　(11):　2653- [Abstract]（ 9 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

2024 Vol. 32　(11):　2663- [Abstract]（ 13 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

To explore the feeding intolerance status of premature infants, to analyze the related factors and to propose the prevention strategies of the feeding intolerance of the infants. Methods: The medical records of 115 premature infants admitted to the hospital from January 2021 to December 2023 were analyzed retrospectively. According to the presence or absence of the feeding intolerance of the infants, these infants were divided into group A (71 cases with the feeding tolerance) and group B (44 cases with the feeding intolerance). The clinical data and the influencing factors of the feeding intolerance of the premature infants in the two groups were analyzed. Results: Among the 115 preterm infants, the incidence of the feeding intolerance was 38.3%. The proportions of the intrauterine distress, the birth asphyxia, the bronchopulmonary dysplasia, the positive pressure respiratory support >24 hours and the caffeine citrate injection, the initial feeding time, the meconium exhaustion time and the amount of the iatrogenic blood collection within one week after birth of the premature infants in group A were significantly lower than those of the premature infants in group B, while the duration of the non-nutritional sucking of the premature infants in group A was significantly higher (all P<0.05). There were no significant differences in the gender, the gestational weeks at birth, the birth weight, the Apgar score at 1 min after birth, the polyembryony, the delivery mode, and the rates of the placental abnormality and the intrauterine infection, the intravenous nutrition time and the kangaroo mother care time of the premature infants between the two groups (P>0.05). Multivariate logistic regression analysis showed that the intrauterine distress (OR=2.344), the birth asphyxia (OR=2.433), the bronchopulmonary dysplasia (OR=2.123), the duration of the positive pressure respiratory support (OR=2.524), the delayed initial feeding (OR=2.008), the longtime of meconium excretion (OR=2.248), the caffeine citrate injection (OR=2.396), the large amount of iatrogenic blood collection within one week after birth (OR=2.109) and the short duration of non-nutritive sucking (OR=2.366) of the premature infants were all the independent factors influencing their feeding intolerance (all P<0.05). Conclusion: The effective intervention measures based on the possible influencing factors of the feeding intolerance of the premature infants should be conducted in clinic timely, so as to improve the feeding status and to promote the growth and development of the premature infants.

2024 Vol. 32　(11):　2673- [Abstract]（ 19 ） HTML (0 KB)  PDF  (0 KB)  ( 6 )

To analyze the evaluation value of the pelvic floor ultrasound for the rehabilitation efficacy of patients with postpartum stress urinary incontinence (PSUI). Methods: 90 patients with PSUI in the 6th weeks after delivery were selected in this study from March to November 2023. 45 patients who had accepted the pelvic floor muscle training were included in group A and 45 patients who had received the electrical stimulation therapy were included in group B. Another 45 women without PSUI were randomly selected in group C. The pelvic floor ultrasonography was used to compare the hiatus area of the levator ani muscle, the urethral rotation angle, the bladder neck mobility and the strain rate of the levator ani muscle of the patients at Valsalva maneuver before and after treatment were compared among the three groups. Results: Before the treatment, the hiatus area of the levator ani muscle, the urethral rotation angle and the bladder neck mobility of the patients in group A and in group B at Valsalva maneuver were significantly higher than those of the patients in group C, and the strain rate of the levator ani muscle of the patients in group A and in group B at Valsalva maneuver was significantly lower (all P<0.05). After 12 weeks of treatment, the hiatus area of the levator ani muscle (21.3±2.1 and 2.4±0.2), the urethral rotation angle (46.7±9.8°and 48.6±10.4°) and the bladder neck mobility (19.0±3.0% and 17.5±3.3%) of the patients in group A and in group B at Valsalva maneuver had decreased significantly. The strain rate of the levator ani muscle of the patients in group A and in group B at Valsalva maneuver after treatment were 19.0±3.0 and 17.5±3.3, which had no change significantly (P>0.05). Conclusion: Both the pelvic floor muscle training and the electrical stimulation are the effective rehabilitation methods for the patients with PSUI. The pelvic floor ultrasound can determine the changes of the pelvic floor morphology and structure of the patients, and which has the role for evaluating the efficacy of the rehabilitation of PSUI of the patients.

2024 Vol. 32　(11):　2683- [Abstract]（ 10 ） HTML (0 KB)  PDF  (0 KB)  ( 7 )

To analyze the health care demand for multiparas during pregnancy. Methods: The survey subjects were selected from the multiparas who underwent routine antenatal examination in the hospital from January 2023 to December 2023. The questionnaire was used to analyze the health care demand and its quantitative scores of the multiparas and the primiparas during pregnancy. The differences of the demand of the pregnancy health knowledge of the multiparas with different demographic characteristics were explored. Results: A total of 1068 questionnaires were distributed, 1051of which were valid, with an effective rate of 98.4%. Among 1051 questionnaires, there were 499 questionnaires answered by the primiparas (in group A) and 552 questionnaires answered by the multiparas (in group B). The demand rates of the knowledge about the birth defect prevention (76.3%) and the pregnancy complications and complications prevention (69.6%) of the women in group A were significantly higher than those (61.1% and 53.5%) of the women in group B. The demand rates of the knowledge about delivery knowledge and neonatal care of the women in group A were significantly lower than those of the women in group B (all P<0.001). There were no significant differences in the demand rates of the knowledge about nutritional health care and mental health care of the women between the two groups (P>0.05). In group A, there was significant difference in the demand of the health care during pregnancy among the multiparas with the different age and among the multiparas with the different education levels. The health care demand of the multiparas during pregnancy had increased with the increase of their age and the education level (all P<0.05). The scores of the health care demand during pregnancy of the multiparas with unplanned pregnancy or with the childbearing interval >5 years (10.66±3.68 points and 10.57±4.43 points) was significantly higher than that (8.36±2.55 points or 7.80±2.73 points) of the multiparas with planned pregnancy or with the childbearing interval ≤5 years (all P<0.05). Conclusion: The demand of the knowledge about the birth defect prevention, the pregnancy complications and the complication preventions of the multiparas during pregnancy is more intense. The targeted health education should be given to the multiparas with different characteristics, so as to meet the demands of the multiparas with different pregnancy experiences in the clinical practice.

2024 Vol. 32　(11):　2691- [Abstract]（ 21 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )

Premature ovarian insufficiency (POI) is one of the most important cause of the female infertility. However, the etiology of POI was still not clearly elucidated. In recent years, with the development of sequencing technologies, such as the whole- exome sequencing and whole-genome sequencing, the genetic etiology of POI has been continuously explored, and then the gene mutations of the women were found to play a more important role in the progression of POI. The studies have found that the TP63 gene is involved in the various stages of the follicle development and maturation. The mutation of TP63 gene of the women induces their follicle apoptosis, leads to the excessive depletion of their follicle numbers and affects their ovarian reproductive function. Therefore, this article describes the influence of the TP63 gene mutation of the women with POI on their follicular development and maturation in the progression, in order to provide the new ideas for the diagnosis and treatment of POI.

2024 Vol. 32　(11):　2707- [Abstract]（ 27 ） HTML (0 KB)  PDF  (0 KB)  ( 5 )