Abstract To investigate the correlation between the serum uric acid level of pregnant women with hypertensive disorders complicating pregnancy (HDP) and their preeclampsia occurrence. Methods: The clinical data of 500 pregnant women with HDP who had diagnosed and treated in the hospital from February 2017 to June 2022 were selected in this study. These women were divided into group A (312 women with the serum uric acid level ≥360 μmol/L) and group B (188 women with the serum uric acid level <360 μmol/L) according to the serum uric acid level of the women. The hypertension grades of the women in the two groups were statistically analyzed. The correlation between the serum uric acid level of the women with HDP and their values of systolic and diastolic blood pressure was analyzed by Pearson correlation analysis. Multivariate Logistic regression analysis was used to evaluate the predictive value of the serum uric acid of the women with HDP for their preeclampsia occurrence. Results: The grade of HDP of the women in group A was significantly higher than that of the women in the group B. The level of serum uric acid of the women with HDP was positively correlated with their values of systolic and diastolic blood pressure. The proportion of the serum uric acid ≥360 μmol/L (81.0%) of the women with PE was significantly higher than that (38.0%) of the women without PE (all P<0.05). Multivariate regression analysis showed that the serum uric acid ≥360 μmol/L, the age ≥35 years old, the pre-pregnancy body mass index ≥28kg/m2, the family history of PE, and the previous history of PE of the women with HDP were all the independent risk factors of their PE occurrence (all P<0.05). Conclusion: The serum uric acid level of the women with HDP is positively correlated with their severity of HDP, and which is the independent risk factors of their PE occurrence.
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