To evaluate the correlation of the transcription factor 7-like2  (TCF7L2) gene rs7903146 and rs290487 polymorphisms of pregnant women and their susceptibility of gestational diabetes mellitus (GDM) in Chinese population. Methods: By searching Chinese and English databases, such as CNKI, Wanfang, Pubmed and Web of science, the case-control studies about the correlation between TCF7L2 gene rs7903146 and rs290487 polymorphisms of the pregnant women and their GDM susceptibility in Chinese population were collected. The relevant studies were searched in these databases up to June 2024. The odds ratio (OR) value and its 95% confidence interval (CI) were calculated to evaluate the correlation between the TCF7L2 gene polymorphisms of the pregnant women and their GDM susceptibility by Stata11.0 software. Results: A total of 10 studies were included, including 2581 women in the cases group and 2738 health women in the control group. The results of meta-analysis showed that the rs7903146 locus polymorphism of the women was positively correlated with the risk of their GDM occurrence (TT vs.CC: OR=5.00, 95%CI 2.70-9.28, Ph=0.946; TT vs. CC+TC: OR=4.63, 95%CI 2.57-8.35, Ph=0.910). The rs290487 locus polymorphism of the women was negatively associated with the risk of their GDM occurrence (TT vs. CC+TC: OR=0.86, 95%CI 0.76-0.97, Ph=0.157). Conclusion: The rs7903146 locus polymorphism of the TCF7L2 gene of the pregnant women in China may be positively correlated with their GDM susceptibility, but the rs290487 locus polymorphism of the TCF7L2 gene of the women may be negatively associated with their GDM susceptibility.