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| Analysis of the influencing factors of the uterine leiomyoma recurrence after laparoscopic surgery |
| Jiaozhou Center Hospital, Qingdao, Shandong Province, 266300 |
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Abstract To analyze the influencing factors of the uterine leiomyoma recurrence of patients after laparoscopic surgery. Methods: The clinical data and the follow-up data of 586 patients who had undergone the laparoscopic surgery of the uterine leiomyoma in the hospital between January 2016 and December 2021 were collected. The situations of the uterine leiomyoma recurrence of the patients were counted. According to the presence or absence of the postoperative uterine leiomyoma recurrence, these patients were divided into group A 82 cases with the uterine leiomyoma recurrence） and group B（504 cases without the uterine leiomyoma recurrence）. The clinical data of the patients were compared between the two groups. The independent risk factors of the postoperative uterine leiomyoma recurrence of the patients were analyzed. Results: The average postoperative follow-up period of the patients was 12.17±4.53 months. The postoperative uterine leiomyoma recurrence rate of the patients was 14.0%, and the postoperative recurrence time of the uterine leiomyoma was 8.71±2.81 months. Univariate analysis showed that the family history of the uterine leiomyoma, the preoperative pregnancy history, the postoperative pregnancy, the main location and size of the uterine leiomyoma, and the body mass index (BMI) at the time of surgery of the patients were not significantly correlation with their postoperative recurrence of the uterine leiomyoma (P>0.05). The age at menarche, the postoperative drug therapy, the uterine leiomyoma number, the age (at the time of surgery), the maximum diameter of the uterine leiomyoma, and the levels of serum estradiol (E2), progesterone (P), prolactin (PRL), folliclestimulating hormone (FSH) and luteinizing hormone (LH) of the patients were significantly correlation with their postoperative recurrence of the uterine leiomyoma (P<0.05). Logistic regression analysis showed that the age ≥40 years old, the number of leiomyoma ≥2, the maximum leiomyoma diameter ≥10cm, and the increased levels of E2, P, PRL, FSH and LH of the patients were the independent risk factors of their uterine leiomyoma recurrence after laparoscopic
surgery (all P<0.05). Conclusion: The recurrence rate of the uterine leiomyomais of the patients after the laparoscopic myomectomy is higher. Clinically, the close attention should be paid to the patients with high-risk of the postoperative uterine leiomyoma recurrence, such as the age ≥40 years old, the multiple and large fibroids, and the high levels of sex hormones. The postoperative follow-up of the patients should be enhanced.
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