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| Study on the correlation between TP63 gene mutation of women and their premature ovarian insufficiency |
| Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing Maternal and Child Health Care Hospital. Beijing, 100006 |
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Abstract Premature ovarian insufficiency (POI) is one of the most important cause of the female infertility. However, the etiology of POI was still not clearly elucidated. In recent years, with the development of sequencing technologies, such as the whole- exome sequencing and whole-genome sequencing, the genetic etiology of POI has been continuously explored, and then the gene mutations of the women were found to play a more important role in the progression of POI. The studies have found that the TP63 gene is involved in the various stages of the follicle development and maturation. The mutation of TP63 gene of the women induces their follicle apoptosis, leads to the excessive depletion of their follicle numbers and affects their ovarian reproductive function. Therefore, this article describes the influence of the TP63 gene mutation of the women with POI on their follicular development and maturation in the progression, in order to provide the new ideas for the diagnosis and treatment of POI.
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