To explore the related factors of the low ovarian response (LOR) of infertile patients with polycystic ovary syndrome (PCOS) after ovulation induction by longterm superovulation during in vitro fertilization-embryo transfer (IVF-ET). Methods: A total of 128 infertile patients with PCOS who had been given ovulation induction by long-term superovulation during IVF-ET between September 1,2018 to September 1,2023 were analyzed retrospectively. All the patients had received treatment of down-regulation, superovulation and oocyte retrieval, and then the ovarian response of the patients was recorded. The baseline data of the patients were collected. According to the number of the of eggs retrieved after intervention, these patients were divided into group A (patients with the numbers of retrieved oocytes ≥4) and group B (patients with the numbers of retrieved oocytes <4). Univariate analysis was used to compare the clinical data of the patients with different ovarian response. Logistic multivariate analysis was used to explore the risk factors of the LOR of the patients after the long protocol for ovulation induction during IVF-ET. Results: In 128 patients, there were 71 cases in group A and 57 cases in group B. Univariate analysis showed that there were significant differences in the body weight, the body mass index and the proportion of the complication with insulin resistance of the patients between the two groups (P<0.05). Multivariate analysis showed that the body mass index (BMI) ≥25.0 kg/m2 and the complication with insulin resistance of the infertile patients with PCOS were the independent risk factors of their LOR after the long protocol for ovulation induction during IVF-ET (P<0.05). Conclusion: The high BMI and the complication with insulin resistance of the infertile patients with PCOS are their independent risk factors of their LOR after the long protocol for ovulation induction during IVF-ET, so the early intervention for the patients should be paid to attention in clinic in order to obtain the better egg retrieval results.