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| Expression levels and the clinical significance of the serum insulin-like growth factor-1 and adiponectin women with hypertensive disorder complicating pregnancy |
| Yan'an People's Hospital, Yan'an, Shanxi Province, 716000 |
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Abstract To investigate the levels of the serum insulin-like growth factor-1 (IGF-1) and adiponectin of pregnant women with hypertensive disorder complicating pregnancy (HDP), and to study the correlation between the levels of serum IGF-1 and adiponectin of the women with HDP and their HDP severity and pregnancy outcomes. Methods: The clinical data of 170 pregnant women with HDP (in study group) who had admitted to the hospital from December 2020 to February 2022 were collected retrospectively, including 71 cases with gestational hypertension, 58 cases with mild preeclampsia and 41 cases with severe preeclampsia. Another 100 healthy pregnant women were selected in control group during the same period. The levels of serum IGF-1 and adiponectin of the women were compares between the study group and the control group, and the value of which of the women for predicting their adverse pregnancy outcomes was evaluated by receiver operating characteristic (ROC) curve. Results: The levels of the IGF-1 (142.31±33.45μg/L) and adiponectin (9.08±2.15mg/L) of the women in the study group were significantly lower than those (219.12±57.48μg/L and 13.92±3.26mg/L) of the women in the control group. The levels of the serum IGF-1 and adiponectin had decreased with the severity of HDP significantly (all P<0.05). The serum levels of the IGF-1 and adiponectin of the women with adverse pregnancy outcomes (76 cases) were significantly lower than those of the women with normal pregnancy outcomes (94 cases) (P<0.05). ROC curve analysis showed that the area under the curve of the serum IGF-1 and adiponectin levels of the women with HDP for predicting their adverse pregnancy outcomes were 0.790 and 0.858. The area under the curve of the serum IGF-1 level and the adiponectin level of the women with HDP for predicting their adverse pregnancy outcomes was similar (P>0.05), but both of which was significantly lower than the that (0.919) of the combined serum IGF-1 and adiponectin levels of the women with HDP for predicting their adverse pregnancy outcomes (all P<0.05). Conclusion: The serum IGF-1 and adiponectin levels of the women with HDP can reflect their severity of HDP, the combination of the serum IGF-1 and adiponectin levels of the women for predicting their adverse pregnancy outcomes has the highest efficacy.
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