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| Predictive value of the gestational weight gain and the abnormal metabolic score of the insulin resistance of pregnant women for the overweigh of their fullterm neonates |
| Wenzhou People's Hospital, Wenzhou, Zhejiang Province, 325000 |
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Abstract To explore the predictive value of the gestational weight gain and the score of the abnormal metabolic score of the insulin resistance (Mets-IR) of pregnant women for the overweigh of their full-term neonates. Methods: The clinical data of 493 pregnant women with singleton pregnancy from January 2019 to July 2023 were collected in this study. The mode of delivery, the age, the education level, the pre-pregnancy body mass index (BMI), the gravidity, the weight gain and the degree of the weight gain during the different stages of pregnancy, the Mets-IR score during the third trimester of pregnancy, and the weight, sex, and height of the newborn of these women were recorded. Logistic regression analysis was used to identify the factors influencing the neonatal overweight of the women. Receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of these various indicators of the women for their neonatal overweight. Results: All of the 493 pregnant women had given birth successfully. There were 133 (27.0%) neonates with birth weight ≥4000 g (4025-4896 g) in group A and 360 (73.0%) neonates with birth weight <4000 g (2501-3978 g) in group B. The neonatal weight at birth, the maternal weight gain (GWG) during the pregnancy, or during the first, the second or the third trimesters of pregnancy, and the Mets-IR score of the neonates in group A were significantly higher than those in group B (P<0.05). Logistic regression analysis showed that GWG (during the pregnancy, or during the first, the second or the third trimesters of pregnancy), the degree of GWG (during the pregnancy, or during the first, the second or the third trimesters of pregnancy), the increased Mets-IR score during the third trimester of pregnancy of the women were correlated with their neonatal overweight (P<0.05). Both GWG and Mets-IR score during the pregnancy of the women had certain values for predicting their neonatal overweight, with the area under the curve (AUC) ≥0.56, the sensitivity ≥42.5% and the specificity ≥24.1%. The AUC (0.838) and the sensitivity (87.2%) of the GWG combined with the Mets-IR score of the women for predicting their neonatal overweight had increased significantly (P<0.05). Conclusion: The GWG and the Mets-IR score during the third trimester of pregnancy of the women are correlated with their neonatal overweight, and the GWG combined with the Mets-IR score of the women can be used as the indexes for predicting their neonatal overweight.
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