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| Levels of the serum 25 hydroxyvitamin D and the insulin growth factor-1 of women with gestational diabetes mellitus and their predictive values for the neonatal hyperbilirubinemia |
| Shanghai Songjiang Maternal and Child Health Care Hospital, Shanghai, 201600 |
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Abstract To investigate the predictive values of the levels of the serum 25 hydroxyvitamin D ［25(OH)D］ and the insulin growth factor-1 (IGF-1) of pregnant women with gestational diabetes mellitus (GDM), and to study the predictive values of the levels of the serum 25(OH)D and IGF-) of the women for their neonatal hyperbilirubinemia (NHB). Methods: From January 2023 to March 2024, 290 pregnant women with GDM were selected in study group and were divided into group A (88 cases with NHB) and group B (202 cases without NHB) according to whether NHB occurred. 266 healthy pregnant women who gave birth during the same period were selected in control group. Logistic regression was applied to analyze the influencing factors of the NHB occurrence. Receiver operating characteristic (ROC) curve was used to analyze the predictive values of the serum 25(OH)D and IGF-1 levels of the women with GDM for their NHB occurrence. Spearman method was applied to analyze the correlation between the serum 25(OH)D and IGF-1 levels of the women with GDM and their NHB occurrence. Results: The serum levels of 25(OH)D (29.64±3.16 ng/ml) and IGF-1 (38.86±4.17 ng/ml) of the women in the study group were significantly lower than those (34.71±3.82 ng/ml and 45.58±4.69 ng/ml) of the women in the control group. In the study group, the serum levels of 25(OH)D (27.54±2.86 ng/ml) and IGF-1 (35.68±3.81 ng/ml) of the women in group A were significantly lower than those (30.55±3.29 ng/ml and 40.25±4.33 ng/ml) of the women in group B (all P<0.05). The high prenatal fasting blood glucose value, the family history of diabetes, the low neonatal Apgar score at 5min after birth, and the low serum 25(OH)D and IGF-1 levels of the women with GDM were the risk factors of their NHB occurrence (P<0.05). The area under the curve (AUC) of the combination of the 25(OH)D and IGF-1 levels of the women with GDM for predicting their NHB occurrence was 0.878, and which was significantly higher than that (0.784) of the 25(OH)D level or that (0.775) of IGF-1 level alone (P<0.001). The serum levels of 25(OH)D and IGF-1 of the women with GDM were negatively correlated with their NHB occurrence (r=-0.409, -0.421, P<0.05). Conclusion: The serum levels of 25(OH)D and IGF-1 of the women with GDM decrease, and which have certain values for evaluating the NHB occurrence of the women.
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