Objective: To systematically evaluate the relationship between isolated thyroid peroxidase antibody positive of pregnant women in the first trimester pregnancy and their thyroid function and pregnancy outcomes in the third trimester pregnancy. Methods: Databases, such as CNKI, VIP, WanFang, PubMed and EMbase were electronically searched to collected casecontrol studies about the association between isolated thyroid peroxidase antibody positive in the first trimester pregnancy and their thyroid function and pregnancy outcomes in the third trimester pregnancy. The articles which matched the including standard were selected, and the related information and data were extracted. Then metaanalysis was performed by Review Manager 5.1 software. Results: A total of 18 articles were included in the meta analysis. The results of metaanalysis showed that, isolated thyroid peroxidase antibody positive in the first trimester pregnancy was related to the increased risks of abortion, fetal intrauterine growth retardation, and abnormal thyroid function (OR=3.35, 1.64, 3.23). Conclusion: Isolated thyroid peroxidase antibody positive in the first trimester pregnancy maybe increase the risks of abortion, fetal intrauterine growth retardation, and abnormal thyroid function in the third trimester pregnancy.

2018 Vol. 26　(12):　1147- [Abstract]（ 316 ） HTML (0 KB)  PDF  (0 KB)  ( 44 )

Objective: To investigate cognitive situation of three blocking mother-to-child diseases (AIDS, syphilis, and hepatitis B) of pre-pregnancy women in partial areas of Jiangsu province. Methods: Random cluster extraction sampling was conducted for including 480 pre-pregnancy women who had received pre-pregnancy health checked in 3 district maternal and child health care and family planning service center of Jiangsu province between Dec 2017 and May 2018. All included women were asked to complete a questionnaire about cognitive situation of three blocking mother-to-child diseases. Results: The overall rate of known three blocking mother-to-child diseases was 52.9%, and there were significant different in basic knowledge, channel of diseases communication, prevention and treatment, and newborn feeding patterns (P<0.05). The multi-factor regression analysis suggested that the cognition situation of three blocking mother-to-child diseases of prepregnancy women was related with district, education and marital status. Conclusion: People in different regions of Jiangsu province should be strengthen publicity. And the content of health education should be enriched based on the misunderstandings of knowledge, and the propaganda methods should be adjusted. A good social atmosphere will develop gradually for promoting the health awareness of people, which including pre-pregnancy women.

2018 Vol. 26　(12):　1160- [Abstract]（ 373 ） HTML (0 KB)  PDF  (0 KB)  ( 67 )

Objective: To compare the effect of intravenous anesthesia between the use of propofol alone and propofol with sufentanil in artificial abortion. Methods: 320 artificial abortion patients with ASA I who had received intravenous anesthesia were randomly divided into two groups (160 cases in each group). The patients in group A were given propofol 2.0mg/kg , and the patients in group B were given sufentanil 0.15μg/kg and propofol 1.5mg/kg. HR, BP, SpO2, total propofol dose, onset time, recovery time, the incidence of artificial abortion syndrome, postoperative nausea vomiting, intraoperative body movement, and patient satisfaction of all included patients were compared between the two groups. Results: HR, BP, SpO2 of all patients in the two groups were stable during anesthesia, and no artificial abortion syndrome was occurred. The total dose of propofol (145.2±54.7mg), onset time of anesthesia (29.6±13.7s), recovery time of anesthesia (3.2±2.6min), and discharge time (145.3±12.4min) of patients in group A had not signifficent different to those of patients in group B(P>0.05), which included total dose of propofol (133.9±49.1 mg), onset time of anesthesia (26.7±12.9s), recovery time of anesthesia (2.7±2.1min), and discharge time (146.2±12.7min). The incidence of nausea (4.4%), vomiting (3.8%), intraoperative body movement (9.4%), patient satisfaction (94.4%) of patients in group A had also not signifficent different to those of patients in group B(P>0.05), which included the incidence of nausea (7.5%), vomiting (6.9%), intraoperative body movement (5.6%), patient satisfaction (91.9%). Patients in both groups had the same satisfaction rate of anesthesia. Conclusion: The sole propofol has the same intravenous anesthesia effect when compared to propofol combined with sufentanil, and has few side effects and less expensive.

2018 Vol. 26　(12):　1168- [Abstract]（ 410 ） HTML (0 KB)  PDF  (0 KB)  ( 83 )

Objective: To investigate the effect of laparoscopic or laparotomy for myomectomy on perioperative stress status and later pregnancy outcomes of patients with uterine myome. Methods: 100 patients with uterine myome were selected from February 2014 to June 2016, and they were divided into two groups according to the random number table. The patients in laparoscopic group (50 cases) underwent laparoscopic myomectomy, and patients in laparotomy group (50 cases) underwent myomectomy by laparotomy. The situations during operation, the later pregnancy outcomes, and the serum level s of reduced glutathione peroxidase (GSH-PX), serum malondialdehyde (MDA), Differences in superoxide dismutase (SOD), epinephrine (E), and norepinephrine (NE) of patients before and after operation were compared between the two groups. Results: The operation time of patients in laparoscopic group was significant longer than that of patients in laparotomy group (P<0.05). The intraoperative blood loss volume and the number of tumors removed of patients in laparoscopic group were significant less than those of patients in laparotomy group (P<0.05). The postoperative exhaust time, time of stay on bed, and time of stay in hospital post operation of patients in laparoscopic group were all significant shorter than those of patients in laparotomy group (P<0.05), and the average postoperative temperature of patients in laparoscopic group was significant lower than that of patients in laparotomy group (P<0.05). The rate of recurrent pregnancy of patients in laparoscopic group was significant lower than that of patients in open operation group (P<0.05). The rate of vaginal delivery of patients in laparoscopic group was significant higher than that of patients in laparotomy group (P<0.05). The cesarean section rate of patients in laparoscopic group was significant lower than that of patients in laparotomy group (P<0.05). The serum levels of GSH-PX, MDA, SOD, E and NE of patients in laparoscopic group were significant lower than those of patients in laparotomy
group (P<0.05). Conclusion: Patients experienced laparoscopic uterine myomectomy have less trauma and mild postoperative stress response, and can recovery rapidly. Laparoscopic uterine myomectomy has less effect on later pregnancy outcomes of patients, so it is the best choice for patients with uterine myome.

2018 Vol. 26　(12):　1175- [Abstract]（ 345 ） HTML (0 KB)  PDF  (0 KB)  ( 79 )

Objective: To investigate the influence of leuprolide acetate combined with Kuntai capsules on endometrial receptivity of patients with endometriosis (EMs) after laparoscopic surgery. Methods: 120 patients with EMs who underwent laparoscopic surgery were randomly divided into observation group and control group (60 cases in each group). The patients in control group were treated by leuprolide acetate after surgery, and the patients in observation group were treated by leuprolide acetate combined with Kuntai capsule. The clinical efficacy, the recurrence rate within 1 year, and the pregnancy status of patients with infertility were compared between the two groups. The serum levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis facto-α (TNF-α), matrix metalloproteinase-9 (MMP-9), soluble intercellular adhesion molecule -1 (sICAM-1), high mobility group box 1 (HMGB1) of patients before and after treatment were detected, the endometrial thickness and uterine artery pulsatility index (PI) and resistance index (RI) of patients were measured by color Doppler ultrasound. Results: There was no significant different in the total effective rate between the two groups (96.7% VS. 93.3%, P>0.05), but the recurrence rate within 1 year of patients in observation group was significant lower than that of patients in control group (5.9% VS.19.2%, P<0.05).After treatment, the levels of serum VEGF, IL-6, TNF-α, MMP-9, sICAM-1 and HMGB1 of patients in observation group were significant lower than those of patients in control group (P<0.05). After treatment,
the endometrial thickness of patients in observation group was significant higher than that of patients in control group, and the uterine artery PI and RI of patients in observation group were significant lower than those of patients in control group (P<0.05). The incidences of hot flashes, night sweats, fatigue, mood swing, sleep disturbance and vaginal dryness of patients in observation group were significant lower than those of patients in control group(P<0.05), but there was no significant different in the incidence of bone pain between the two groups (P>0.05). As for the patients with infertile, the cumulative pregnancy rates of patients at 6 and 12 months after surgery in observation group was 45.5% and 68.2%, which were significant higher than those of patients in control group (16.0% and 36.0%, respectively, P<0.05). Conclusion: The application of leuprolide acetate combined with Kuntai capsules used for patients with EMs after laparoscopic surgery can improve the endometrial capacity, can improve the pregnancy rate of infertility patients, and can reduce the recurrence rate. The mechanism may be related to its antiinflammatory effect and downregulation of VEGF expression.

2018 Vol. 26　(12):　1183- [Abstract]（ 372 ） HTML (0 KB)  PDF  (0 KB)  ( 83 )

Objective: To investigate the effect of pelvic exercise combined with pelvic floor electrical stimulation for treating postpartum pelvic floor dysfunction. Methods: 300 patients with pelvic floor dysfunction admitted to Shanghai Changning district maternal and child health care hospital from September 2016 to February 2018 were randomly divided into two groups. The patients in observation group (150 cases) were treated by pelvic exercise combined with pelvic floor electrical stimulation for 6 weeks, and the patients in control group (150 cases) were treated by pelvic exercise for 6 weeks. The electrophysiological indexes of pelvic floor of patients were measured before and after treatment, and the degree of pelvic organ prolapse and the quality of sexual life were evaluated by POP-Q and PISQ-12. Results: After treatment, the pelvic floor muscle strength, myoelectricity, fatigue, POP-Q index, and sexual life quality were significantly improved. Compared with those of patients in control group, the proportion of patients with pelvic floor 3 to 5 muscle strength in observation group after treatment was significant increased (80.7% VS. 68.0%, P<0.05). The average potential of type I and type II muscle fibers of patients in observation group were significant higher than those of patients in control group (18.02±2.55μv VS. 21.05±6.51μv, 13.25±1.97μv VS. 18.05±2.57μv, P< 0.05). The fatigue degree of type I and type II muscle fibers of patients in observation group were significant lower than those of patients in control group (4.02±0.55%/s VS. 4.26±0.49%/s, 6.33±1.02%/s VS. 6.59±1.02%/s, P<0.05). The proportion of patients with 0 degree of POP-Q indexing of patients in observation group was significant higher than that of patients in control group (86. 0% VS. 64.0%, P<0.05). There was no significant different in the PISQ-12 score between the two groups (31.5±17.7 points VS. 32.8±12.9 points, P>0.05). Conclusion: Pelvic exercise combined with pelvic floor muscle stimulation can significantly improve the pelvic floor muscle strength of patients with pelvic floor dysfunction, can reduce the degree of pelvic organ prolapse, and can improve the quality of sexual life.

2018 Vol. 26　(12):　1192- [Abstract]（ 344 ） HTML (0 KB)  PDF  (0 KB)  ( 49 )

Objective: To observe the clinical value of the changes of serum YKL 40 and visfatin levels of pregnant women with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: From July 2017 to July 2018, 82 pregnant women with OSAHS admitted to Weihai municipal hospital of Shandong province were included in observation group, and 60 health pregnant women who had regular antenatal checkup were in control group. The women in observation group were also divided into mild OSAHS group (32 cases), middle OSAHS group (32 cases), and severe OSAHS group (18 cases) according to the results of polysomnography. All included pregnant women had undergone PSG monitoring, and their serum levels of YKL 40 and visfatin were detected. The apnea hypopnea index (AHI), minimum oxygen saturation (LSaO2), mean oxygen saturation (SaO2), serum YKL 40 level of pregnant women were compared among the different groups. Pearson correlation analysis was used to analyze the relationship between serum level of YKL 40 or visfatin and the severity of disease of pregnant women with OSAHS. ROC analysis was used to analyze the value of serum levels of YKL 40 and visfatin for predicting of OSAHS occurring during pregnancy. Results: The AHI of pregnant women in observation group was significant higher than that of pregnant women in control group (P<0.05), LSaO2 was significant lower than that of pregnant women in control group (P<0.05), but there was no significant different in SaO2 between observation group and control group (P>0.05). In pregnant women of observation group, AHI increased gradually with the severity of OSAHS (P<0.05), and LSaO2 decreased gradually with the severity of OSAHS (P<0.05). The changes of serum level of YKL 40 and visfatin of pregnant women in observation group were significant higher than those of pregnant women in control group (P<0.05). AHI and LSaO2 were positively correlated with serum level of YKL 40 (r=0.619, 0.435, P<0.05), and AHI and LSaO2 were positively correlated with serum level of visfatin (r=0.537, 0.402, P<0.05), but SaO2 was no associated with serum level of YKL 40 or visfatin (r=0.064, 0.038, P>0.05). The area under the curve (AUC) of serum level of YKL40 and visfatin for diagnosing OSAHS of pregnant women was 0.830 and 0.719, respectively. The sensitivity of serum level of YKL40 and visfatin were 86.3% and 82.1%, respectively, and the specificity of serum level of YKL40 and visfatin were 82.2% and 79.1%, respectively. Conclusion: The serum levels of YKL 40 and visfatin of pregnant women with OSAHS are significantly increased, and are closely related to the severity of OSAHS. Monitoring the levels of serum YKL 40 and visfatin during pregnancy can provide evidence for preventing the occurrence of OSAHS during pregnancy.

2018 Vol. 26　(12):　1200- [Abstract]（ 262 ） HTML (0 KB)  PDF  (0 KB)  ( 64 )

Objective: To explore the efficacy and safety of bilateral uterine artery embolization combined with curettage for treating patients with uterine scar pregnancy. Methods: A total of 86 patients with uterine scar pregnancy after history cesarean section in Jiangbei people's hospital were selected from January 2014 to January 2018. All patients were randomly divided into 2 groups (43 cases in each group). The patients in study group were treated by bilateral uterine artery embolization combined with curettage, while the patients in control group were treated by methotrexate combined with curettage. In 3 months after abortion, the clinical symptoms, level of blood-human chorionic gonadotropin (β-HCG), and rate of adverse reaction were compared between the two groups. Results: Compared with those of patients in control group, the disappearance time of the tumor, the duration of vaginal bleeding, the recovery of normal menstrual time postabortion, the continuous vaginal bleeding time, the amount of bleeding during operation, and the level of peripheral blood β-HCG of patients in study group had significantly reduced (P<0.05), and the time of vaginal bleeding after operation of patients in study group had significantly increased (P<0.05). In control group, there were 11 patients (25.6%) with the postoperative pain, 6 patients (14.0%) with gastrointestinal reactions, 6 patients (14.0%) with fever, 4 patients (9.3%) with pelvic infection, and 2 patients (4.7%) with lower extremity venous thrombosis. And in study group, there was no case of pelvic infection and lower extremity venous thrombosis, and there were 4 patients (9.3%) with postoperative pain, 1 patient (2.3%) with gastrointestinal reactions, and 1 patient (2.3%) with fever. Compared with that of patients in control group, the patients in study group had fewer postoperative pain, gastrointestinal reactions and fever (P<0.05). Conclusion: Bilateral uterine artery embolization combined with curettage is effective for treating patients with uterine scar pregnancy, which has good cure rate. The uterine scar pregnancy disappears rapidly, the duration of vaginal bleeding is shorter, and the other clinical indicators are effectively improved.

2018 Vol. 26　(12):　1207- [Abstract]（ 381 ） HTML (0 KB)  PDF  (0 KB)  ( 73 )

Objective: To explore the change of serum levels of adropin and Ghrelin of patients with polycystic ovary syndrome, and to anlyze its related factors. Methods: The data of 62 patients with polycystic ovary syndrome who had treated in Shenghen Nanshan maternity and child health care hospital from October 2016 to October 2017 were retrospective collected. These 62 patients were in observation group, and the data of another 30 normal women (in control group) were retrospective collected also during the same time. Age, body mass index(BMI), waist-to-hip ratio(WHR), and levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), high-density lipoprotein(HDL), testosterone(T), iuteinizing hormone(LH), follicle stimulating hormone(FSH), fasting glucose, 1h glucose, 2h glucose, fasting insulin, 1h insulin, and 2h insulin, and insulin resistance index(HOMA-IR), adropin and Ghrelin of patients were compared between the two groups. The correlation between serum level of adropin or Ghrelin and above indicators was analyzed. Results: The BMI, and levels of LDL, T, LH, 2h blood glucose, fasting insulin, 1h insulin and 2h insulin, and HOMA-IR of patients in observation group were significant higher than those of patients in control group, but the levels of HDL, adropin and Ghrelin of patients in observation group were significant lower than those of patients in control group (P＜0.05). Pearson correlation analysis showed that the level of adropin was negatively correlated with levels of fasting insulin, 1h insulin, 2h insulin or HOMA-IR. The level of Ghrelin was negatively correlated with BMI, WHR, levels of T and fasting blood glucose, and was positively related to HDL(P＜0.05). Conclusion: Serum levels of adropin and Ghrelin -IR. Ghrelin level is negatively correlated with BMI, WHR, and levels of T and fasting blood glucose, and is positively correlated with the level of HDL.

2018 Vol. 26　(12):　1216- [Abstract]（ 366 ） HTML (0 KB)  PDF  (0 KB)  ( 73 )

Objective: To explore the clinical efficacy of uterine artery embolization for treating puerperae with refractory postpartum hemorrhage, and to analyze the influencing factors of surgical treatment failure. Methods: The clinical data of 121 puerperae with refractory postpartum hemorrhage who had admitted to rocket general hospital from June 2012 to June 2018 were retrospectively analyzed. All included patients had undergone uterine artery  embolization. According to the result of treatment by uterine artery embolization, they were divided into treatment success group and treatment failure group. The general data and operation situation were compared between the two groups. Logistic regression was used to analyze the risk factors of treatment failure. Results: In the 121 patients, 110 (90.9%) cases were successfully treated and 11 (9.09%) were failed. Among the 11patients with treatment failure, 6 cases underwent total hysterectomy, and 5 cases were treated with uterine artery embolization again. In that 5 cases treated by uterine artery embolization again, the 4 cases were successfully treated and 1 case underwent total hysterectomy because of treatment failure again. Univariate analysis showed that puerperae with diffuse intravascular coagulation, scar uterus, injury of soft birth canal, placental factors, gestational complications, and combined use of uterotonics were risk factors for failure of uterine artery embolization. Multivariate logistic regression analysis showed that a puerpera with disseminated intravascular coagulation, scar uterus, gestational complications, or combined use of uterotonics was an independent risk factor for the failure of uterine artery embolization. Conclusion: Uterine artery embolization for treating puerperae with refractory postpartum hemorrhage is effective, has high success rate and good hemostasis efficacy. Disseminated intravascular coagulation, scar uterus, gestational complications, or combined use of uterotonics was an independent risk factor for the failure of uterine artery embolization to treat puerperae with diffuse intravascular coagulation,
so a reasonable treatment plan should be developed for such patients based on the patient's specific conditions.

2018 Vol. 26　(12):　1223- [Abstract]（ 324 ） HTML (0 KB)  PDF  (0 KB)  ( 66 )

Objective: To investigate the value of serum testosterone (T), sex hormone binding globulin (SHBG), C-reactive protein (CRP), and beta trace protein (BTP) during the second trimester and the third trimester pregnancy for predicting pregnancy induced hypertension. Methods: 60 pregnant women with pregnancy induced hypertension in Zhongda hospital affiliated to Southeast university were included in study group, and 60 healthy pregnant women were in control group. The serum levels of T, SHBG, CRP and BTP of all included pregnant women during the second trimester and the third trimester pregnancy were detected, and were compared between the two groups. The predictive value of serum levels of T, SHBG, CRP or BTP for pregnancy induced hypertension was analyzed. Results: There were no significant different in serum levels of T and CRP between the two groups (P>0.05). The serum SHBG level of pregnant women in study group were significant lower than that of pregnant women in control group (P<0.05). The serum BTP level of pregnant women in study group was significant higher than that of pregnant women in control group (P<0.05). In pregnant women of study group, the BTP levels of pregnant women with proteinuria during the second trimester and the third trimester pregnancy were significant higher than those of pregnant women without proteinuria, but the SHBG levels were significant lower than those of pregnant women without proteinuria (P<0.05). The levels SHBG and BTP of pregnant women in study group were positively correlated with gestational weeks, level of SHBG was negatively correlated with SBP and DBP, and level of BTP was positively correlated with SBP and DBP (P<0.05). The critical value of SHBG for diagnosing pregnancy induced hypertension was 376.3ng/ml, and its sensitivity and specificity was 90.5% and 88.6%, respectively. The critical value of BTP for diagnosing pregnancy induced hypertension was 322.4ng/ml, and its sensitivity and specificity was 92.4% and 89.5%, respectively. Conclusion: The serum levels of T and CRP are no significant correlation with the occurrence of pregnancy induced hypertension during the second trimester and the third trimester pregnancy. The serum levels of SHGB and BTP are significantly correlated with the occurrence of pregnancy induced hypertension, and have higher sensitivity and specificity for diagnosing pregnancy induced hypertension, which have good predictive value for pregnancy induced hypertension.

2018 Vol. 26　(12):　1231- [Abstract]（ 390 ） HTML (0 KB)  PDF  (0 KB)  ( 86 )

Objective: To investigate the changes of sex hormone and insulin levels of childbearing age women with PCOS and hyperandrogenemia, and to provide evidences for clinical diagnosis and treatment of women with PCOS who had menstrual disorder, infertility, or other symptoms. Methods: 200 women with PCOS and hyperandrogenemia in Tianjin central obstetrics and gynecology hospital from September 2011 to August 2014 were included in PCOS group, and 200 healthy women were recruited in control group during the same period. The serum levels of testerone (T), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), Pesterone (P), fasting insulin (FINS) of all included women were detected by electrochemiluminescence immunoassay, and fasting plasma glucose (FPG) level was measured by glucose-oxidase method. The insulin resistance was calculated through the homeostasis model assessment (HOMA-IR). Results: Among 200 women in PCOS group, 81% women had hyperinsulinemia, 85.4% women had insulin resistance, and 42% women had hyperluteinemia. Compared with those of women in control group, the serum levels of T, E2, LH, LH/FSH radio, FINS and HOMA-IR of women in PCOS group were significant higher (P<0.05). Conclusion: Women with PCOS and hyperandrogenemia have hormonal disorders, such as hyperinsulinemia, insulin resistance, and hyperluteinemia. In order to reduce the pain of patients and to decrease the incidence of disease, it is important to monitor hormone levels, and to  treat for alleviating the clinical symptoms and improving patients' endocrine environment.

2018 Vol. 26　(12):　1239- [Abstract]（ 417 ） HTML (0 KB)  PDF  (0 KB)  ( 77 )

Objective: To investigate the expression of serum micro RNA-126 and level of vascular endothelial cell adhesion molecule-1 (sVCAM-1) of pregnant women with gestational diabetes mellitus (GDM), and to analyze their relationship with glycolipid metabolism of pregnant women with GDM. Methods: 85 pregnant women with GDM from February 2016 to February 2018 were selected in study group, and 60 normal pregnant women were selected in control group. The miR-126 expression, and serum levels of sVCAM-1, fasting blood glucose (FPG), fasting insulin (FINS), glycerol (TG), cholesterol (TC), apolipoprotein A (apoA), apolipoprotein B (apoB), high-density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) of all pregnant women were detected, and insulin resistance index (HOMA-IR)was calculated. The correlation between miR-12 expression, sVCAM-1 level and indexes of abnormal glycolipid metabolism was analyzed. Results: The serum levels of TG, LDL-C, apoA and apoB of pregnant women in study group were significant higher than those of pregnant women in control group (P<0.05), and the HDL-C level of pregnant women in study group was significant lower than that of pregnant women in control group (P<0.05), but there was no significant different in TC level between the two groups (P>0.05). The levels of FPG, FINS, HOMA-IR and sVCAM-1 of pregnant women in study group were significant higher than those of pregnant women in control group (P<0.05), and the expression of miR-126 of pregnant women in study group was significant lower than that of pregnant women in control group (P<0.05). The expression of miR-126 was negatively correlated with the level of TG, LDL-C, FPG, FINS, HOMA-IR or apoA (r=-0.328, -0.510, -0.324, -0.336, -0.616, -0.456, -0.315, P<0.05), and the expression of miR-126 was positively correlated with the level of HDL-C (r=0.335, P<0.05), but the expression of miR-126 was irrelevant with the level of TC or apoB (r=-0.013, -0.015, P>0.05). sVCAM-1 level was positively correlated with the level of TG, FPG or HOMA-IR (r=0.433, 0.637, 0.301, P<0.05), sVCAM-1 level was negatively correlated with the level of HDL-C (r=-0.325, P<0.05), sVCAM-1 level was irrelevant with the level of TC, LDL- C, FINS, apoA,  or apoB (r=0.040, 0.158, 0.012, 0.008, P>0.05). The level of TG（OR=2.310，95% CI: 0.681-1.264) or HOMA-IR（OR=1.272，95% CI: 0.261-0.961) was the independent influencing factor for the expression of miR-126, and the level of TG（OR=1.862，95 %CI: 0.136-0.769) was the independent influencing factor for sVCAM-1 level. Conclusion: Serum miR-126 expression of pregnant women with GDM is significantly down-regulated, and sVCAM-1 level of pregnant women with GDM is increased. Serum miR-126 and Serum sVCAM-1 may be involved in abnormal glycolipid glucose metabolism of pregnant women with GDM.

2018 Vol. 26　(12):　1245- [Abstract]（ 357 ） HTML (0 KB)  PDF  (0 KB)  ( 79 )

Combination sustained release contraceptive vaginal ring had listed in United states in 2001, which is a new contraceptive method. Although it is not been used in China, it has been used abroad for many years. Combination sustained release contraceptive vaginal ring is a long acting contraception including estrogen combined with progesterone, and its contraceptive effectiveness and clinical characteristics is similar to compound oral contraceptives. The users of combination sustained release contraceptive vaginal ring can take it into vagina or take out by themselves. This article focuses on the using method and security of combination sustained release contraceptive vaginal ring.

2018 Vol. 26　(12):　1265- [Abstract]（ 342 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )