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Abstract Objective: To investigate the expression of serum micro RNA-126 and level of vascular endothelial cell adhesion molecule-1 (sVCAM-1) of pregnant women with gestational diabetes mellitus (GDM), and to analyze their relationship with glycolipid metabolism of pregnant women with GDM. Methods: 85 pregnant women with GDM from February 2016 to February 2018 were selected in study group, and 60 normal pregnant women were selected in control group. The miR-126 expression, and serum levels of sVCAM-1, fasting blood glucose (FPG), fasting insulin (FINS), glycerol (TG), cholesterol (TC), apolipoprotein A (apoA), apolipoprotein B (apoB), high-density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) of all pregnant women were detected, and insulin resistance index (HOMA-IR)was calculated. The correlation between miR-12 expression, sVCAM-1 level and indexes of abnormal glycolipid metabolism was analyzed. Results: The serum levels of TG, LDL-C, apoA and apoB of pregnant women in study group were significant higher than those of pregnant women in control group (P<0.05), and the HDL-C level of pregnant women in study group was significant lower than that of pregnant women in control group (P<0.05), but there was no significant different in TC level between the two groups (P>0.05). The levels of FPG, FINS, HOMA-IR and sVCAM-1 of pregnant women in study group were significant higher than those of pregnant women in control group (P<0.05), and the expression of miR-126 of pregnant women in study group was significant lower than that of pregnant women in control group (P<0.05). The expression of miR-126 was negatively correlated with the level of TG, LDL-C, FPG, FINS, HOMA-IR or apoA (r=-0.328, -0.510, -0.324, -0.336, -0.616, -0.456, -0.315, P<0.05), and the expression of miR-126 was positively correlated with the level of HDL-C (r=0.335, P<0.05), but the expression of miR-126 was irrelevant with the level of TC or apoB (r=-0.013, -0.015, P>0.05). sVCAM-1 level was positively correlated with the level of TG, FPG or HOMA-IR (r=0.433, 0.637, 0.301, P<0.05), sVCAM-1 level was negatively correlated with the level of HDL-C (r=-0.325, P<0.05), sVCAM-1 level was irrelevant with the level of TC, LDL- C, FINS, apoA, or apoB (r=0.040, 0.158, 0.012, 0.008, P>0.05). The level of TG（OR=2.310，95% CI: 0.681-1.264) or HOMA-IR（OR=1.272，95% CI: 0.261-0.961) was the independent influencing factor for the expression of miR-126, and the level of TG（OR=1.862，95 %CI: 0.136-0.769) was the independent influencing factor for sVCAM-1 level. Conclusion: Serum miR-126 expression of pregnant women with GDM is significantly down-regulated, and sVCAM-1 level of pregnant women with GDM is increased. Serum miR-126 and Serum sVCAM-1 may be involved in abnormal glycolipid glucose metabolism of pregnant women with GDM.
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