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| The efficacy of lowdose progesterone injection combined with Baotaiwuyou capsule for treating patients with threatened abortion |
| The Second Affiliated Hospital of Xi 'an Medical College, Xi’an, Shanxi Province, 710038 |
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Abstract Objective: To investigate the efficacy of low-dose progesterone injection combined with Baotaiwuyou capsule for treating patients with threatened abortion. Methods: 94 patients with threatened abortion admitted to the second affiliated hospital of Xi 'an medical college from March 2017 to March 2018 were included and were divided into two groups according to the random number table method. The 47 patients in the control group were given intramuscular injection of low-dose progesterone, 20mg/d, once a day, and 47 patients in observation group were given Baotaiwuyou capsule (4 capsules/time, 3 times per day) except intramuscular injection of low-dose progesterone. Efficacy of patients in both groups was evaluated after 2 weeks treatment. The time of clinical symptom remission, the abdominal pain and back pain VAS score, serum P, E2, and β-hCG levels before and after treatment were recorded. The incidences of adverse reactions of patients in both groups were also observed. Results: The total effective rate of patients in observation group was 95.7%, which was significantly higher than that (78.7%) of patients in control group (P<0.05). The disappearance time of vaginal bleeding, relief time of lower abdominal pain and backache of patients in observation group were significant shorter than those of patients in control group (P<0.05). The VAS scores of patients after treatment were significant lower than those of patients before treatment in both groups (P<0.05), but the VAS scores of patients in observation group was significant lower than that of patients in control group after treatment (P<0.05). The levels of serum P, E2, and β-hCG of patients increased significantly after treatment in both groups (P<0.05), but the levels of serum P, E2, and β-hCG of patients in observation group were significant higher than those of patients in control group after treatment (P<0.05). The incidence of adverse reactions of patients in observation group was 8.5%, which was equivalent to that (10.6%) of patients in control group (P>0.05). Conclusion: Low-dose progesterone injection combined with Baotaiwuyin capsule has an exact therapeutic effectiveness for treating patients with threatened abortion. It can significantly improve the clinical symptoms, can reduce the pain level of patients, and can up-regulate the levels of serum P, E2, and β-hCG, and it has good safey.
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