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Abstract Objective: To explore the change of serum levels of adropin and Ghrelin of patients with polycystic ovary syndrome, and to anlyze its related factors. Methods: The data of 62 patients with polycystic ovary syndrome who had treated in Shenghen Nanshan maternity and child health care hospital from October 2016 to October 2017 were retrospective collected. These 62 patients were in observation group, and the data of another 30 normal women (in control group) were retrospective collected also during the same time. Age, body mass index(BMI), waist-to-hip ratio(WHR), and levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), high-density lipoprotein(HDL), testosterone(T), iuteinizing hormone(LH), follicle stimulating hormone(FSH), fasting glucose, 1h glucose, 2h glucose, fasting insulin, 1h insulin, and 2h insulin, and insulin resistance index(HOMA-IR), adropin and Ghrelin of patients were compared between the two groups. The correlation between serum level of adropin or Ghrelin and above indicators was analyzed. Results: The BMI, and levels of LDL, T, LH, 2h blood glucose, fasting insulin, 1h insulin and 2h insulin, and HOMA-IR of patients in observation group were significant higher than those of patients in control group, but the levels of HDL, adropin and Ghrelin of patients in observation group were significant lower than those of patients in control group (P＜0.05). Pearson correlation analysis showed that the level of adropin was negatively correlated with levels of fasting insulin, 1h insulin, 2h insulin or HOMA-IR. The level of Ghrelin was negatively correlated with BMI, WHR, levels of T and fasting blood glucose, and was positively related to HDL(P＜0.05). Conclusion: Serum levels of adropin and Ghrelin -IR. Ghrelin level is negatively correlated with BMI, WHR, and levels of T and fasting blood glucose, and is positively correlated with the level of HDL.
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