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Abstract Objective: To explore the value of positron emission computer tomographic/computed tomography (PET/CT) combined with serum levels of alpha fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) for diagnosing patients with ovarian cancer. Methods: 138 patients with suspected ovarian cancer admitted to Shuguang hospital from March 2015 to April 2017 were selected as the research subjects, 67 patients with ovarian cancer and 71 patients with benign ovarian tumor were diagnosed by pathology as gold standard. The enzyme linked immunosorbent assay was used to detect serum AFP and CA19-9 levels of patients, and all included patients were also given PET/CT detection, the ROC curve was used to analyze the diagnostic values of serum levels of AFP and CA19-9. The diagnostic efficacy of PET/CT, serum levels AFP and CA19-9 were compared. Results: The sensitivity, specificity and accuracy of PET/CT were 71.3%, 63.6% and 68.8%, respectively. The SUVmax of PET/CT of patients in ovarian cancer group was significant higher than that of patients in benign ovarian tumor group (P<0.05). The levels of serum AFP and CA19-9 of patients in ovarian cancer group were significant higher than those of patients in ovarian benign tumor group (P<0.05). The ROC curve showed that the dividing value of AFP for diagnosing ovarian cancer was 18.35ng/ml, and its sensitivity, specificity, Jorden index were 54.6%, 74.4%, 0.424, respectively. The dividing value of CA19-9 for diagnosing ovarian cancer was 232.61U/ml, and its sensitivity, specificity, and Jorden index were 87.2%, 38.6%, 0.687, respectively. The accuracy and sensitivity of joint detection of PET/CT, serum levels AFP and CA19-9 were 91.3% and 96.8%, respectively, which were significantly higher than those of PET/CT, AFP or CA199 only (P<0.05). Conclusion: In the early diagnosis of ovarian cancer, PET/CT combined with serum levels of AFP and CA19-9 has a high accuracy and sensitivity, and has important value for differentiating benign and malignant tumors.
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