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| The value of levels of sFlt 1, PIGF, 25 hydroxyvitamin D, and D dimer for diagnosising pregnant women with preeclampsia |
| Jiangbei Hospital Affiliated to Southeast University (Nanjing Dachang Hospital), Nanjing, Jiangsu Province, 21000 |
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Abstract Objective: To investigate the value of levels of sFlt 1, PIGF, 25 hydroxyvitamin D, and D dimer for diagnosising pregnant women with preeclampsia. Methods: The data of 540 pregnant women who had undergone prenatal examination in Nanjing Dachang hospital were retrospective analyzed, which included 30 pregnant women with preeclampsia (in observation group) and 510 normal pregnant women (in control group). The levels of sFlt 1, PIGF, 25 hydroxyvitamin D and D dimer of pregnant women in both groups were detected, and the sensitivity and specificity of the levels of sFlt 1, PIGF, 25 hydroxyvitamin D or D dimer for diagnosing preeclampsia were analyzed. Results: The levels of sFlt 1 and D dimer of pregnant women in observation group were significant higher than those of pregnant women in control group, and the levels of PIGF and 25 hydroxyvitamin D of pregnant women in observation group were significant lower than those of pregnant women in control group (P<0.05). In observation group, the sFlt 1 and Ddimer levels of pregnant women with mild preeclampsia were significant lower than those of pregnant women with severe preeclampsia, and the PIGF and 25 hydroxyvitamin D levels of pregnant women with mild preeclampsia were significant higher than those of pregnant women with severe preeclampsia (P<0.05). The area under the ROC curve of levels of sFlt 1, PIGF, 25 hydroxyvitamin D, and D dimer are all >0.8, which had high sensitivity and specificity for diagnosing preeclampsia. The sFlt 1 and Ddimer levels combined with the PIGF and 25 hydroxyvitamin D levels for diagnosing preeclampsia had higher sensitivity(88.9%) and specificity (98.4%)(P<0.05). Conclusion: Combination of detection of levels of sFlt 1, PIGF, 25 hydroxyvitamin D and D dimer of pregnant women during the first trimester pregnancy has high value for diagnosing preeclampsia.
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