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Abstract Objective: To observe the clinical value of the changes of serum YKL 40 and visfatin levels of pregnant women with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: From July 2017 to July 2018, 82 pregnant women with OSAHS admitted to Weihai municipal hospital of Shandong province were included in observation group, and 60 health pregnant women who had regular antenatal checkup were in control group. The women in observation group were also divided into mild OSAHS group (32 cases), middle OSAHS group (32 cases), and severe OSAHS group (18 cases) according to the results of polysomnography. All included pregnant women had undergone PSG monitoring, and their serum levels of YKL 40 and visfatin were detected. The apnea hypopnea index (AHI), minimum oxygen saturation (LSaO2), mean oxygen saturation (SaO2), serum YKL 40 level of pregnant women were compared among the different groups. Pearson correlation analysis was used to analyze the relationship between serum level of YKL 40 or visfatin and the severity of disease of pregnant women with OSAHS. ROC analysis was used to analyze the value of serum levels of YKL 40 and visfatin for predicting of OSAHS occurring during pregnancy. Results: The AHI of pregnant women in observation group was significant higher than that of pregnant women in control group (P<0.05), LSaO2 was significant lower than that of pregnant women in control group (P<0.05), but there was no significant different in SaO2 between observation group and control group (P>0.05). In pregnant women of observation group, AHI increased gradually with the severity of OSAHS (P<0.05), and LSaO2 decreased gradually with the severity of OSAHS (P<0.05). The changes of serum level of YKL 40 and visfatin of pregnant women in observation group were significant higher than those of pregnant women in control group (P<0.05). AHI and LSaO2 were positively correlated with serum level of YKL 40 (r=0.619, 0.435, P<0.05), and AHI and LSaO2 were positively correlated with serum level of visfatin (r=0.537, 0.402, P<0.05), but SaO2 was no associated with serum level of YKL 40 or visfatin (r=0.064, 0.038, P>0.05). The area under the curve (AUC) of serum level of YKL40 and visfatin for diagnosing OSAHS of pregnant women was 0.830 and 0.719, respectively. The sensitivity of serum level of YKL40 and visfatin were 86.3% and 82.1%, respectively, and the specificity of serum level of YKL40 and visfatin were 82.2% and 79.1%, respectively. Conclusion: The serum levels of YKL 40 and visfatin of pregnant women with OSAHS are significantly increased, and are closely related to the severity of OSAHS. Monitoring the levels of serum YKL 40 and visfatin during pregnancy can provide evidence for preventing the occurrence of OSAHS during pregnancy.
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