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| The influences of hydroxychloroquine combined with hormone drug on outcomes of maternal and infant, serum IFN-γ and IL-10 levels of pregnant women with systemic lupus erythematosus |
| Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, 2000082 |
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Abstract Objective: To observe the influence of hydroxychloroquine combined with hormone drug on outcomes of maternal and infant, and serum interferon-γ (IFN-γ) and interleukin-10 (IL-10) levels of pregnant women with systemic lupus erythematosus (SLE). Methods: 92 pregnant women with SLE were randomly divided into two groups.46 pregnant women in control group were treated by hormone drug, and 46 pregnant women in study group were treated by hydroxychloroquine combined with hormone drug. The systemic lupus erythematosus disease activity index (SLEDAI) during pregnancy and the outcomes of maternal and infant of all included pregnant women in both groups were recorded, and the serum levels of IFN-γ and IL-10 of all pregnant women in the first trimester pregnancy and ante partum were detected. The adverse reactions of pregnant women were compared between the two groups during treatment. Results: SLEDAI scores of all pregnant women in the second trimester pregnancy and the last trimester pregnancy were significantly lower than those of pregnant women in the early trimester pregnancy (P<0.05), and SLEDAI scores of pregnant women in study group were significant lower than those of pregnant women in control group (P<0.05). The rate of fullterm pregnancy of pregnant women in study group was significant higher than that of pregnant women in control group (P<0.05), but there were no significant different in rates of early termination pregnancy, premature delivery, and neonatal asphyxia, and rate of low birth weight, and the neonatal weight, and Apgar score of newborn at 5 minutes after birth between the two groups (P>0.05). The serum levels of IFN-γ and IL-10 of all pregnant women before delivery were significant lower than those of all pregnant women in the first trimester pregnancy (P<0.05), and the serum levels of IFN-γ and IL-10 of pregnant women in study group were significant lower than those of pregnant women in control group (P<0.05). There was no significant different in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Hydroxychloroquine combined with hormone drug for treating pregnant women with SLE can significantly improve outcomes of maternal and infant, and can reduce serum levels of IFN-γ and IL-10.
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