To analyze the status of induced abortion and contraceptive in China, and to provide evidence for achieving reproductive health targets listed in Sustainable Development Goals (SDGs) and China’s National Action Plan for 2030 Sustainable Development Goals. Methods：The data of contraceptive prevalence rates, numbers of induced abortions, and numbers of live births were collected from the China Health and Family Planning Statistical Yearbook, and the average number of women of childbearing age was collected from the China Statistical Yearbook. And induced abortion rates and the rations of induced-abortion number to livebirth number were calculated based on these data. Results：The induced abortion rate of Chinese women increased from 2014 to 2016, and that was reached 28.13‰ in 2016, but slightly declined in 2017. The ratios of induced abortion numbers to live-birth numbers showed similar trend as induced abortion rate, which ratios were all above 0.5 in each year during 2014 and 2017. The contraceptive rate of married women with childbearing age had remained above 80% during 2009 and 2017, but had been declining since 2010. There was a lacking of statistical data on the contraceptive prevalence rate of unmarried but sexually active women, although several nationwide surveys had revealed low utilization of contraceptives by these women. Unmarried women accounted for a significant share of the total numbers of induced abortion. Conclusions：Although married women of childbearing age keep a higher contraceptive prevalence rate, the rate of induced abortion of Chinese women also keep high, which implies that the contraceptive services may not sufficient, especially unmarried people have poor access to contraceptive services and their needs for contraceptives are not met. The government should improve the quality of contraceptive services to meet the needs of women and to implement post abortion care so as to reduce abortion and repeated abortion numbers. Special attention should be paid to provide reproductive health services for unmarried people particularly sexually active adolescents to meet their unmet needs for contraceptives. Comprehensive sex education that includes gender equality and rights should be provided for adolescents.

2019 Vol. 27　(3):　276- [Abstract]（ 705 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

To study the effect of semen persicae on mouse model with physiological menstruallike. Methods: The pseudopregnant mouse received bilateral ovariectomy after artificial decidualization, whichtriggered progesterone withdrawal, resulted in endometrium break down, and mimiced the physiology of menstruation. Semen persicae was administrated to the mouse model in semen persicae group onlybefore progesterone withdrawal until 24 hours(h) after progesterone withdrawal, and the general morphology and histomorphometry of mousewere observed. Results:At 24h after progesterone withdrawal,the color of mouse uterus insemen persicae group was darker, and the hyperemia was more pronounced, when compared with those of mouse in control group. There was larger number of red blood cells exudation in the break down area of endometrium, as well as the basal layer adjacent to peripheral endometrium, and the red blood cells were widely distributed among endometrial stromal cells, while the above phenomenon were not observed in the control group. Statistical analysis showed that the relative breakdown area and relative hyperemia area ofmouse in semen persicae group were similar to those of mousein control group, but the relative hyperemia area ofmouse in semen persicae group was significant higher that of mouse in control group (P=0.009）. Conclusion: Semen persicaecan promote the exudation of red blood cell in mouse model withphysiologicalmenstrual-like, however its pharmacological effects and functional mechanism need to be further studied.

2019 Vol. 27　(3):　286- [Abstract]（ 309 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

 To explore the stress status and coping strategies of women who wanted the second child. Methods：A total of 594 pluripara who wanted the second child from outpatient of hospital were selected from January to June 2018, and they were surveyed on their basically situations by questionnaire self-designed, and the pregnancy pressure scale (PPS) was used to evaluate the pregnancy stress, the stress reaction questionnaire (SRQ) and coping style questionnaire (CSQ) were used to evaluate the coping strategies of included women. The relationship between the pregnancy stress, stress reaction and coping strategies were analyzed. Results: The score of PPS of the women was (21.3±7.6)points, and which scoring coefficient was 23.7%.The score of SRQ was (56.3±12.3)points, and which scoring coefficient was 47.3%. The scores of negative response and positive score by CSQ were ( 25.3±8.7)points and (34.63±9.14)points, which scoring coefficients were 50.6% and 57.7%, respectively. The main source of stress of women were the pressure of maternal and child health and safety, and pressure of postpartum body shape change. In addition to“the pressure of parental role", the score of SRQ and negative coping strategies was positively correlated with the score of the PPS, while the score of positive coping strategies was negatively correlated with the score of the PPS (P<0.05). Logistic regression analysis showed that stress response and negative coping were risk factors for pregnancy stress, while positive coping style was the protective factor (P<0.05).Conclusion: The pluripara who wanted the second child have mild pregnancy stress generally. The pregnancy stress are closely related to stress response and individual coping style, and active response is beneficial to relieve pregnancy stress.

2019 Vol. 27　(3):　295- [Abstract]（ 354 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

To compare the clinical effect of activated γIUD between IUD inserted immediately after abortion and IUD inserted 3-7 days after menstruation. Methods: From August 2016 to March 2017, 221 women who inserted activated γIUD immediately after abortion were selected in observation group, and another 219 women who inserted activated γIUD 3-7 days after menstruation were selected in control group during the same time. The clinical effects of women when followed up 3 months, 6 months and 1 year after activated γIUD inserted were compared between the two groups. Results: The removal rate of women with 28 model IUD inserted was significant than that of women with 26 model IUD inserted in observation group (P<0.05), but there was no significant different in other type IUD between the two group (P>0.05).Conclusion: Women inserted activated γIUD immediately after abortion doesn’t increase the removal rate of IUD and has better safety, so it is worthy of promotion.

2019 Vol. 27　(3):　305- [Abstract]（ 501 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )

 To investigate the effect of cervical COOK double balloon combine with rivanol amniocentesis for induction of labor during the second trimester of pregnant women with scar uterus. Methods: 120 pregnant women during the second trimester with scar uterus were enrolled in the study from January 2016 to January 2018, and they were divided into 3 groups according to the random number table. 40 women in group A were treated by COOK double balloon combined with mifepristone, 40 women in group B were treated by COOK double balloon combined with rivanol amniocentesis, and 40 women in group C were treated by rivanol combined with mifepristone. The cervical Bishop score, blood pressure, effect of induction of labor, and bleeding volume of women were compared among the three groups. Results: The Bishop scores of women in group A or group B increased after treatment, and which was significant higher than that of women in group C (P<0.05).The effect of women in group A and group B was significant higher than that of women in group C (P<0.05), and the time of induction of labor of women in group A or group B was significant shorter than that of women in group C (P<0.05). There were no significant differences in uterine contraction time and bleeding volume among the three groups (P>0.05). There were no any women with cervical tears, uterine rupture, or profuse bleeding in the three groups. Conclusion: Cervical COOK double balloon for pregnancy induction of labor during the second trimester of patients can effectively promote cervical ripening, shorten the time of induction of labor, and have fewer complications.

2019 Vol. 27　(3):　312- [Abstract]（ 356 ） HTML (0 KB)  PDF  (0 KB)  ( 59 )

To investigate the therapeutic effect of Xinfuning on cervical diseases by human papillomavirus (HPV) infected，and to study its effect on immunity of patients. Methods: 90 women with HPV infection-related cervical diseases were divided into the control group and study group from May 2016 to May 2017. The women in control group were treated by conventional therapy, and the women in study group were treated by Xinfuning except conventional therapy. The situation of T lymphocyte subsets, and the change of immunoglobulin and inflammatory cytokines of women in the two groups before and 1 month after treatment were recorded and compared, and the clinical efficacy and recurrence of HPV infected of women in the two groups after 6 months were also recorded. Results: Before treatment, the levels of CD3+ T cells, CD8+ T cells, CD4+ CD25+ T cells, Foxp3+ Tregs, IgA, IgG and IgM, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interferon(IFN) and interleukin-6 (IL-6) of women in both groups had no significant different(P>0.05). After treatment, all above indexes of women in both groups had improved, and the changes of all above indexes of women in control group were significant better than those of women in control group (P<0.05). 6 months after treatment, the incidence of HPV infected again of women in control group was significant lower than that of women in control group(P<0.05). Conclusion: Xinfuning can be used to treat HPV infection-related cervical diseases, which can decrease rate of HPV infected again of women by improving the levels of T lymphocyte subsets, immunoglobulin, and inflammatory cytokines.

2019 Vol. 27　(3):　320- [Abstract]（ 420 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )

 To analyze the correlation between body mass index and semen quality of infertile men. Methods: 100 infertile men were selected as subjects from January 2015 to March 2018.According to the difference of body mass index (BMI), the included man were divided into group A (BMI<18.5), group B (18.5<BMI<23.9), group C (24.0<BMI<27.9) and group D (BMI>30.0).All the man were measured the quality parameters of semen. The correlation between the BMI and the quality of semen were analyzed. Results: The level of estradiol (E2) of man in group C or group D was significant higher than that of man in group A or group B, but the level of testosterone (T) were significant lower (P<0.05). The semen volume and total number of sperm of man in group B was highest by analyzing the median and quartile spacing of parameters of semen quality(P<0.05). There was no significant difference in the other parameters of residual semen quality among the four groups (P>0.05). Conclusion: There is a certain correlation between BMI of male body mass index and the quality of semen. When BMI is over 28, the level of T and LH reduce obviously, which can decrease the vitality of sperm.

2019 Vol. 27　(3):　327- [Abstract]（ 395 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

To analyze the pregnancy outcomes of women with history cesarean section after vaginal delivery (VBAC), and to explore its correlation with scar thickness of women. Methods: From January 2016 to May 2018, 159 pregnant women with history cesarean section who underwent vaginal trial delivery (TOLAC) were divided into two groups according to the thickness of scar tissue measured by ultrasound. The scar thickness of women in group A (85 cases with scar uterus grade Ⅰ) was 3-7mm, and that in group B (74 cases with scar uterus grade II) was 2-3mm. And another 120 pregnant women without history cesarean section who also experienced vaginal delivery were selected in group C. The pregnancy outcomes of women were analyzed and compared among the three groups. The success rate of VBAC of pregnant women was analyzed and compared between group A and group B. Results: The success rate of TOLAC of women in group A and group B was 66.7%. There were no significant different in the total time of labor, rates of postpartum hemorrhage, postpartum hemorrhage volume, hospitalization time of women, and neonatal weight, Apgar score, and complications, and rate of neonate transferred to pediatric department between the women with vaginal delivery successfully and women with TOLAC failure (P>0.05). In group A and group B, the gestational age, pre-pregnancy BMI index, gestational age, and neonatal weight of women with vaginal delivery were significant lower than those of women with TOLAC failure (P<0.05), but the muscular thickness of the lower uterine of women with vaginal delivery was significant higher than that of women with TOLAC failure (P<0.05). The success rate of vaginal delivery (87.1%) of women in group A was significant higher than that (43.2%) of women in group B (P<0.05). Conclusion: The pregnant women with history cesarean section experienced TOLAC is safety, but the medical pointer of TOLAC should be strict. Women with scar tissue thickness ≥ 2mm is safety for vaginal delivery, and the thicker the scar tissue, the higher the success rate of delivery. The scar tissue thickness of uterus can be as one of evaluation indication of TOLAC.

2019 Vol. 27　(3):　335- [Abstract]（ 398 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )

To explore the influence of dydrogesterone combined with progynova on levels of endometrium TNF-α, VEGF, TGF-β of women with intrauterine adhesions after operation, and to study the clinical efficacy of dydrogesterone combined with progynova. Methods: 156 women with moderate intrauterine adhesions were randomly divided into control group (n=78) and observation group (n=78) from February 2015 to May 2017. The women after operation in control group were treated by progynova, and the women in observation group were treated by dydrogesterone combined with progynova. The changes of tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) in the endometrium of women were compared between the two groups, and the clinical efficacy and adverse reactions rate of women in both groups were observed. Results: Before treatment, there was no significant difference in the levels of TNF-α, VEGF and TGF-β of women between the two groups (P>0.05). After treatment, the levels of TNF-α, VEGF and TGF-βof women in the two groups were significantly lower than those before treatment (P<0.05), and the levels of TNF-α, VEGF and TGF-βof women in observation group were significantly lower than those of women in the control group (P<0.05).The rates of menstrual improvement and pregnancy of women in observation group were significant higher than those of women in control group, but the recurrence rate of intrauterine adhesions was significant lower than that of women in control group. There was no significant different in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dydrogesterone combined with progynova can effectively decrease the expression of endometrium TNF-α, VEGF and TGF-β of women, which can improve the clinical efficacy，and do not increase the adverse reactions of women with intrauterine adhesions after operation.

2019 Vol. 27　(3):　342- [Abstract]（ 447 ） HTML (0 KB)  PDF  (0 KB)  ( 46 )

To explore the efficacy of cyclosporin A for treating pregnant women with aplastic anemia, and to study its influence on pregnancy outcome. Methods: 170 pregnant women with aplastic anemiawere were selected and divided into observation group (n=90) and control group (n=80) by random number table method from April 2015 to April 2017. The women in control group were treated by kanglilong, and the women in observation group with were treated by cyclosporin A. The clinical efficacy, levels of WBC, PLT and VEGF, pregnancy outcomes, and rate of adverse reactions were compared between the two groups. Results: The total effective rate of observation group was 91.1%, which was significant higher than that (71.3%) of control group (P<0.05). The levels of WBC, PTL and VEGF of women in observation group were significant higher than those of women in control group (P<0.05). The incidences of gestational hypertension, postpartum hemorrhage, low birth weight, premature birth and neonatal asphyxia of women in observation group were significant lower than those of women in the control group (P<0.05). The total incidence of adverse reactions of women in observation group was 11.1%, which was significant lower than that (23.8%) of women in control group (P<0.05). Conclusion: Cyclosporin A treating pregnant women with aplastic anemia has significant efficacy, which can improve pregnancy outcomes with high safety, so it is worthy of clinical promotion.

2019 Vol. 27　(3):　349- [Abstract]（ 392 ） HTML (0 KB)  PDF  (0 KB)  ( 44 )

2019 Vol. 27　(3):　355- [Abstract]（ 322 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

To detect the expression of micro RNA-425-5p (miR-425-5p) in serum and tissues of patients with endometrial carcinoma, and to explore the relationships between different expression levels with prognosis of patients. Methods: 84 patients with endometrial carcinoma were selected in study group from April 2014 to May 2015, and 50 healthy women were selected in control group. QRT-PCR was used to detect the expression of miR-425-5p in the serum, cancer tissues, and adjacent tissues of patients. Results: The serum level of miR-425-5p of patients in study group was significant higher than that of patients in control group (P<0.05).The expression of miR-425-5p in endometrial carcinoma tissues was significant higher than that in adjacent normal tissues (P <0.05). The expression of miR-425-5p in serum and tissues was correlated to the tumor stage, lymph node metastasis and differentiation (P<0.05). The overall survival rate of patients with low miR425-5p expression in serum and tissues was significant higher than that of patients with low mi425-5p expression (P<0.05). COX analysis showed that the expression of miR-425-5p in serum and tissues, and the degree of tissue differentiation were independent risk factors for the prognosis of patients (P<0.05). Conclusion: The expressions of MiR-425-5p in serum and tissues up-regulate, which is related to the prognosis of patients, so it can be used as reference index for prognosis assessment.

2019 Vol. 27　(3):　363- [Abstract]（ 345 ） HTML (0 KB)  PDF  (0 KB)  ( 53 )

To observe the effects of oxytocin combined with balloon abdominal pressure belt for preventing postpartum hemorrhage of women with labor analgesia during the third stage of labor. Methods: 98 women of full-term primiparas with singleton and cephalic presentation who undergone labor analgesia were divided into study group and control group according to the random number table method (49 cases in each group). The women in study group were treated by oxytocin combined with balloon abdominal pressure belt during the third stage of labor, and the women in control group were treated by oxytocin during the third stage of labor in the third stage of labor. The bleeding volume of women was compared between the two groups during the third stage of labor, at placenta delivery, or at 2h after delivery. The total labor time, the neonatal Apgar score at 1min and 5min, and the pulse (times/min), systolic blood pressure (SBP) and diastolic blood pressure (DBP) of women at 2h after delivery were recorded. Results: The bleeding volume of women in study group during the third stage of labor, at placenta delivery, or at 2h after delivery was significant lower than that of women in control group. The time of the third stage of labor or total labor of women in study group was significant less than that of women in control group (P<0.05). There were no significant difference in the neonatal Apgar score at 1 min and 5 min, and pulse, SBP, and DBP of women at 2h after delivery between the two groups (P>0.05). Conclusion: Oxytocin combined with balloon abdominal pressure belt for treating women during the third stage of labor can significantly reduce the postpartum hemorrhage of puerperas with labor analgesia, and shorten the time of the third stage of labor and total labor, and it will not affect the neonatal.

2019 Vol. 27　(3):　371- [Abstract]（ 316 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )

To investigate the psychological state of senile pregnant who undergone magnetic resonance imaging (MRI) examination, and to analyze the intervention effect of imported health education for those elderly pregnant women. Methods: Ninety-seven elderly pregnant women who undergoing MRI examination in the third people's hospital of Hubei province between January 2014 and December 2017 were selected as subjects, and their psychological state before MRI examination was investigated by self designed questionnaires. Among them, 80 women who had finished questionnaires effectively were divided randomly into observation group (n=40) and the control group (n=40). The women in control group were given routine clinical preparation for MRI examination, and the women in observation group were given imported health education intervention before MRI examination. The psychological states of the 80 women were observed. The improvement of psychological state after the intervention, and completion situation and image quality of MRI examination were compared. Results: In the 80 elderly pregnant women, the ratios of anxiety and fear, distrust, reverse psychology and self-distrust were 67.5%, 38.8%, 30.0% and 38.8%, respectively. The proportions of unhealthy psychological state such as anxiety and fear, distrust, reverse psychology and selfdistrust of women in observation group decreased significantly after intervention (P<0.01) and were significant lower than those of women in control group (P<0.01). There was no significant different in completion situation of MRI examination between the two groups (P>0.05), but the score of image quality of MRI examination of women in observation group was significant higher than that of women in control group (P<0.01). Conclusion: The elderly pregnant women who undergoing MRI examination has some unhealthy psychological state. Imported health education can effectively alleviate the unhealthy psychological status, and can improve the compliance of MRI examination to obtain better examination effect.

2019 Vol. 27　(3):　382- [Abstract]（ 392 ） HTML (0 KB)  PDF  (0 KB)  ( 49 )

Mitochondrion is a critical indicator of oocyte quality. The abnormal quantity and function of mitochondrial will lead to the low quality of oocytes or embryos. In this review, we will discuss the biological role of mitochondria of oocyte and its function in reproduction, and will study the clinical value of mitochondrial transplantation for improving ovarian reserve function.

2019 Vol. 27　(3):　404- [Abstract]（ 423 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )