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| The clinical significances of serum PECAM-1 and sVEGFR-1 levels of women with hypertensive disorder complicating pregnancy |
| Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital, Beijing, 101300 |
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Abstract To investigate the changes of serum platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) of women with hypertensive disorder complicating pregnancy (HDCP), and to study their clinical significances. Methods: From February 2017 to February 2018, 36 pregnant women with HDCP were randomly selected in group A, 58 pregnant women with preeclampsia were randomly selected in group B, and 34 normal pregnant women were randomly selected in group C. The serum PECAM-1 and sVEGFR-1 levels of women were compared among the three groups. Results: The PECAM-1 expression of women in group C was highest, and that of women in group B was lowest. The sVEGFR-1 expression of women in group C was lowest, and that of women in group B was highest. The levels of PECAM-1sVEGFR-1 and sVEGFR-1 of women in group B had significant different than those of women in group A and C (P<0.05).The multivariate regression analysis had showed that PECAM-1 level and sVEGFR-1 level were independent risk factors for HDCP (P<0.05). Conclusion: The levels of PECAM-1 and sVEGFR-1 can be used as important parameters for HDCP, which is worthy of clinical attention.
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