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| The research progress and mechanism of Vitamin D in recurrent miscarriage |
| 1.Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, 400020；2.Affiliated Hospital of Chongqing Institute of Population and Family Planning Science and Technology |
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Abstract Recurrent miscarriage (RM) refers to a spontaneous abortion that occurs over 2 times before 20 gestational weeks, and its incidence in women of childbearing age is about 1% to 3%. Maintenance of normal pregnancy requires the mother to develop immune tolerance to the fetus. If the immune tolerance mechanism is destroyed and not treated promptly, it will cause RM. Vitamin D (VitD) has been shown to play an important role in regulating immune balance between mother and fetus, promoting maternal immune tolerance to the fetus, and maintaining normal pregnancy. Studies have shown that VitD level is closely related to RM. This article reviews the mechanism of VitD for maintenance of pregnancy and its current research progress in order to providing evidence for clinical treatment of RM caused by lack or deficiency of VitD.
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