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| Effect of Labetalol on inflammatory factors levels and hemorheology of pregnant women with pregnancy induced hypertension |
| The Tenth People’s Hospital of Tongji University, Shanghai, 200072 |
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Abstract To investigate the effect of Labetalol on inflammatory factors and hemorheology of pregnant women with pregnancy induced hypertension. Methods: 100 pregnant women with pregnancy induced hypertension from September 2015 to September 2016 were selected as the study subjects, and they were divided into control group and observation group according to the random number table method (50 cases in each group).The women in control group were treated by magnesium sulfate, and the women in observation group were treated by magnesium sulfate and labetalol. The changes of inflammatory factors levels and hemorheological parameters of women were compared before and after treatment and between the two groups. Results: Before treatment, there was no significant different in inflammatory factors levels and blood rheology parameters of women between the two groups (P>0.05). After treatment, levels of inflammatory factors of women in both groups, such as HMGB1, HCY, CysC, and values of hemorheology blood viscosity, plasma viscosity, and HCT reduced significantly, and these indicator of women in observation group were significant lower than those of women in control group (P<0.05). After treatment, the natural delivery rate of women in observation group was significant higher than that of women in control group, and the incidences of cesarean section, postpartum hemorrhage, and postpartum complications of women in observation group were significant lower than those of women in control group (P<0.05). Conclusion: Labetalol combined with magnesium sulfate treatment can significantly decrease inflammatory stress of women with pregnancy induced hypertension, and can improve their hemodynamic parameters and pregnancy outcomes.
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