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| Expression of MiR-425-5p in serum and tissues of patients with endometrial carcinoma and its correlation to the prognosis |
| lishui City People's Hospital, Zhejiang Province, 323000 |
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Abstract To detect the expression of micro RNA-425-5p (miR-425-5p) in serum and tissues of patients with endometrial carcinoma, and to explore the relationships between different expression levels with prognosis of patients. Methods: 84 patients with endometrial carcinoma were selected in study group from April 2014 to May 2015, and 50 healthy women were selected in control group. QRT-PCR was used to detect the expression of miR-425-5p in the serum, cancer tissues, and adjacent tissues of patients. Results: The serum level of miR-425-5p of patients in study group was significant higher than that of patients in control group (P<0.05).The expression of miR-425-5p in endometrial carcinoma tissues was significant higher than that in adjacent normal tissues (P <0.05). The expression of miR-425-5p in serum and tissues was correlated to the tumor stage, lymph node metastasis and differentiation (P<0.05). The overall survival rate of patients with low miR425-5p expression in serum and tissues was significant higher than that of patients with low mi425-5p expression (P<0.05). COX analysis showed that the expression of miR-425-5p in serum and tissues, and the degree of tissue differentiation were independent risk factors for the prognosis of patients (P<0.05). Conclusion: The expressions of MiR-425-5p in serum and tissues up-regulate, which is related to the prognosis of patients, so it can be used as reference index for prognosis assessment.
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