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DUAN Xueyan, MA Jainan, MING Meiying
To optimize the formulation and preparation technology of gestodene loaded microneedles for contraceptive, and to evaluate the in vitro characteristic of the gestodene loaded microneedles. Methods: The mold casting technique was used to prepare the gestodene loaded microneedles. The matrix materials of these microneedles were selected based on their needle-forming ability and the flexibility. The influence of the adding sample volume and the vacuum drying time on the morphology of the microneedles was researched during the preparation process. The solubility, the puncture performance, the mechanical strength and the in vitro transdermal release behavior of the microneedles were evaluated. Results: Because of the good formation and the certain flexibility, 100 mg/ml PVPK90 was preferred as the optimal matrix solution. The optimal preparation process of the gestodene loaded microneedles included the adding sample volume of 150μl and the vacuum dry of 45 minutes. The gestodene loaded microneedles had certain mechanical strength, which could penetrate the stratum corneum of the porcine skin. The in vitro gestodene release amount of the microneedles was approximately 20μg/cm2 for 7 days consecutively, and which was best fitted by the Higuchi model. The dissolution process of the gestodene loaded microneedles after piercing into the rat skin was evaluated, and the result showed that the microneedles were almost dissolved within 2 min. Conclusion: The preparation method of the gestodene loaded microneedles is simple and the microneedles can slow release gestodene for contraception, and which provides a novel and convenient route for the subcutaneous sustained release contraceptive.
2024 Vol. 32 (6): 1220- [Abstract]（
81
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WANG Xin1,2, MAO Qunxia1,2, DENG Mengcong1,2, ZHU Yujia1,2, WU Shangchun1, WANG Hongwei3
To develop an assessment tool for the quality of post-abortion contraceptive (PAC) counseling service from the perspective of service providers, and to provide the uniform standard for the subsequent assessment of the quality of the counseling services of PAC in various medical facilities. Methods: The assessment tool for the quality of PAC counseling service was developed through the literature review and the expert consultation. The participants were the medical personnel who had provided PAC counseling services in 17 domestic medical facilities. The data were collected through ‘Wenjuanxing’ and all the scale-type entries in the assessment tool were evaluated for intrinsic and split-half reliability, structural, convergent, and discriminant validity. Results: There were 100 questionnaires collected, with a valid recovery rate of 100%. The intrinsic reliability Cronbach's αcoefficient was 0.818, and the split-half reliability coefficient was 0.941. The structural validity: χ2/df=1.605, Root Mean Square Error of Approximation (RMSEA)=0.078, Tucker-Lewis index (TLI)=0.912, and Comparative Fit Index (CFI)=0.928. The average variance extracted (AVE) for each dimension was all >0.5, and the correlation coefficients among the dimensions were less than the square root of AVE. Conclusion: The PAC counseling service quality assessment tool developed from the perspective of the service providers in this study has ideal reliability and validity, which can be applied to assess the quality of the PAC counseling services.
2024 Vol. 32 (6): 1225- [Abstract]（
85
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LIU Huicong1,2, CAO Xiaofang1, WAN Zirui1,3, AN Lisha1, JIN Xiaohua1, MA Xu1,2
To evaluate the efficacy of the C-to-G basic group editor (CGBE) Td-CGBE-NG in targeted knockout of the proprotein convertase subtilisin/kexin type 9 (PCSK9) genes of huh-7 hepatocellular carcinoma cells based on the reference of CBE (AncBE4max). Methods: The PCSK9 gene of the huh-7 hepatocellular carcinoma cells was knocked out by a strategy involving the introduction of a stop codon. The basic group editors of Td-CGBE-NG and AncBE4max were constructed, and the recombinant plasmids of sg386 and sg555 were generated. Co-transfection of Td-CGBE-NG and sg386, or AncBE4max and sg555, was conducted to the huh-7 cells to induce the conversion of c.1447C>G and c.1953C>T, thereby introducing the stop codons S386X (TGA) and Q555X (TAG) at the two positions. The editing efficiency was validated by the sanger sequencing and T-vector cloning. The changes of PCSK9 mRNA and protein expression levels were detected by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting. Results: The results of the sanger sequencing and T-vector cloning showed that the editing efficiencies of Td-CGBE-NG and AncBE4max were c.1447C>G 33% and c.1953C>T 25%. RT-qPCR analysis revealed the reduction of PCSK9 mRNA expression by Td-CGBE-NG (t=17.29, P＜0.0001). Western blotting confirmed protein expression levels in both groups of huh7 cells had decreased significantly （AncBE4max:t=5.57,P＜0.01；Td-CGBE-NG:t=4.912, P＜0.01）. Conclusion: Td-CGBE-NG can knockout the PCSK9 gene of the huh-7 hepatocellular carcinoma cells effectively, which leading to the inhibition of the gene mRNA and protein expressions. These findings lay a foundation for the future application of Td-CGBE-NG.
2024 Vol. 32 (6): 1231- [Abstract]（
74
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WANG Long1, XIE Wenlu1, HUANG Jiaxin1, WU Siyu1, LIU Meiya1, LUI Youhong1, XU Die1, YANG Ying2, MA Xu2
To analyze medication among Chinese women with pregnancy intention, and to provide the data support for promoting the preconception health of the women. Methods: A total of 871 152 women who had participated in the National Free Pre-pregnancy Checkups Project (NFPCP) and had self-reported medication during 2013-2019 were included as the study objects. All the self-reported medications were parsed with the reference of National Essential Drugs List published in 2018. Descriptive epidemiological method was used to analyze the characteristics of the prepregnancy medication of the women, and Chi-square test was used to analyze the distribution differences of the medication according to the baseline characteristics. Results: Up to 2.2% of the women with planning pregnancy had reported medication usage, with a diverse range of drug types being reported. The prepregnancy medications primarily comprised of vitamin/mineral drugs (64.1%), followed by obstetrics, gynecology, and family planning drugs (7.5%), antimicrobials (6.8%), hormones and drugs influencing the endocrine system (6.7%), analgesic /antipyretic /anti-inflammatory /anti-rheumatic /anti-gout drugs (5.4%) and traditional Chinese herbal medicine (5.0%). The women with advanced age, Han nationality, high school education level above, urban household registration, non-farmer occupation, delivery history, history of adverse pregnancy, or overweight or obese had tend to have the higher usage rates of antimicrobial drugs, hormones, drugs influencing the endocrine system, analgesic and antipyretic/anti-inflammatory /anti-rheumatic /anti-gout drugs, and traditional Chinese herbal medicine. Conclusion: The diversity of prepregnancy medications is complex, and which is presenting challenges for ensuring the safe medication usage and the health counselling. During the pre-pregnancy health counselling, attention should be directed towards the medication usage among the women with advanced age, Han nationality, high school education level above, urban household registration, non-farmer occupation, delivery history, history of adverse pregnancy, and overweight or obese. It is crucial for identifying the potential risks of medication-induced pregnancy and embryonic toxicity, thus decreasing the occurrence of the adverse pregnancy outcomes associated with the prepregnancy medication used of the women.
2024 Vol. 32 (6): 1236- [Abstract]（
64
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XIAO Xinyan，SUN Shuli
To investigate the status of the postpartum depression (PPD) of pregnant women with gestational diabetes mellitus (GDM), and to analyze the influencing factors of PPD. Methods: From June 2021 to August 2023, 274 pregnant women with GDM were selected in this study. These women were divided into group A (women with PPD) and group B (women without PPD) according to their PPD occurrence evaluated in the postpartum 6th week. The data in 21 items of the women in the two groups were collected by “pregnant women with GDM survey questionnaire”, and these data of the women were compared between the two groups. The factors related to PPD of the women were screened by multivariate analysis. Results: A total of 59 (21.5%) women with PPD were screened in this study. There were significant differences in the marital relationship, the personality type, the proportions of the newborns gender meeting the expectations, newborn diseases, postpartum diabetes and postpartum sleep disorders of the women between the two groups (P<0.05). The poor marital relationship (OR=2.249, 95%CI 1.213-4.170), the susceptible personality (OR=3.219, 95%CI 1.771-5.853), the newborns gender not meeting the expectation (OR=2.098, 95%CI 1.118-3.936), the postpartum diabetes (OR=2.517, 95%CI 1.376-4.603) and the postpartum sleep disorder (OR=2.846, 95%CI 1.609-5.034) of the women with GDM were the risk factors of their PPD occurrence. Conclusion: The poor marital relationship, the susceptible personality, the newborns gender not meeting the expectation, and the postpartum diabetes and sleep disorder of the women with GDM are related to their PPD occurrence. Therefore, it is necessary to strengthen the psychological situations of the pregnant women with GDM and with the above-mentioned characteristics, and the precise interventions should be carried out for these women timely to prevent and control their PPD occurrence.
2024 Vol. 32 (6): 1242- [Abstract]（
75
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ZHU Yuping1, ZHU Qinqin1, QIN Jinfeng2
To understand the depression status of patients with cervical cancer during the radiotherapy from two top three hospitals in Nantong, and to analyze the influencing factors of the depression of the patients, in order to provide the guidance for the accurate prevention of the depression of the patients. Methods: A total of 1623 patients with cervical cancer who wanted the radiotherapy from two top three hospitals in Nantong from March 2019 to May 2023 were selected in this study. During the mid-term of the radiotherapy of the patients, the hospital anxiety and depression scale (HADS) was applied to assess their depression status. The general information, the diagnostic and treatment data, and the social support of the patient were obtained. Univariate analysis was used to analyze the depression status of the patients, and the influencing factors of the depression of the patients were screened by logistic regression. Results: The incidence of the depression of the patients with cervical cancer during their radiotherapy was 29.8% (483/1623). There was significant difference in the incidence of depression among the patients with different educational levels, among the patients with different monthly family income, among the patients with different tumor staging, among the patients with different treatment plans, among the patients with different degree of toxic side effects, and among the patients with different social support (P<0.05). Logistic regression analysis showed that the risk factors of the depression of the patients during radiotherapy mainly included the low education level, the low monthly family income, the advanced tumor, the concurrent radiotherapy and chemotherapy, the moderate or severe toxicity and the moderate or low social support. Conclusion: This survey shows that the patients with cervical cancer have a higher probability of their depression occurrence during radiotherapy. Th low educational level, the low monthly family income, the advanced tumor, the concurrent radiotherapy and chemotherapy, the moderate or severe toxicity and the moderate and the low social support of the patients are the risk factors of their depression occurrence. Therefore, in order to prevent the depression occurrence of the patients with cervical cancer during radiotherapy, it is necessary to take the accurate preventive intervention measures for the patients based on the above risk factors.
2024 Vol. 32 (6): 1247- [Abstract]（
88
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SONG Yangguang1, XU Ruihao1, DENG Guoyan2, HU Nashun2, XU Yuping2, SIQIN Qimuge2, HUGE Jiletu3, BAO Jinhua3, YANG Shuo1, SUN Liwen1, ZHANG Bin1, WANG Shangming1, ZHANG Shucheng1, WU Shangchun1
To investigate the menarche and the menstruation patterns of female students in Mongolian areas of China. Methods: Cross-sectional cluster sampling was used to investigate the menstruation pattern of the female students in Tongliao from 2013 to 2018 by one-to-one and face-to-face interviews under the unified standard. Results: A total of 4052 female students (1872 Han nationality and 2180 Mongolian nationality) were investigated, with a success rate of 97.1%. The mean age of the menarche of the female students was 12.9±1.1 years old, and which of the Han and Mongolian female students were 12.8±1.1 years old and 12.9±1.1 years old. There was significant difference in the mean age of menarche between the Han female students and the Mongolian female students (t=4.30, P=0.000). The incidences of the second menstrual period of the female students within 1, 2, 4 and 6 months after menarche were 65.8%, 82.1%, 92.9% and 97.7%, respectively. The cumulative rates of the menstruation stable state of the female students within 1, 2, 4 and 6 months after menarche were 65.8%, 82.1%, 92.9% and 97.7%, respectively. The time of the menstruation stable state of the female students from rural area was significantly earlier than that of the female students from urban area (χ2=21.49, P=0.001). The proportion of the female students with normal menstrual cycle was 72.2%, and which had significant difference of the female students between Han nationality and Mongolian nationality (χ2=4.05, P=0.044). The proportion of the menstrual period of 4-7 days of the female students accounted for 81.1%. The proportions of the little, less, average, more and much more menstrual volume of the female students were 4.7%, 7.9%, 69.1%, 10.7% and 7.6%, respectively. Most female students had dysmenorrhea, and the rate of the dysmenorrhea of female students had increased gradually with their prolong menstruation (52.5%-84.1%). The dysmenorrhea degree of the female students included the mild dysmenorrhea of 72.1% (the slight dysmenorrhea of 47.3% and the general dysmenorrhea of 24.7%), the moderate dysmenorrhea of 26.5% and the severe dysmenorrhea of 1.5%, and there was significant difference in the dysmenorrhea degree of the female students between the urban area and the rural area (χ2=20.52,P=0.000). Conclusion: The menarche age of the Han female students is earlier than that of the Mongolian female students in Mongolian areas. The female students from rural areas enter the menstrual stable state after menarche early. There are differences in the menstrual cycle between the Han female students and the Mongolian female students. Most female students have dysmenorrhea, but their dysmenorrhea degree is mild. There is significant difference in the dysmenorrhea degree of the female students the between the urban area and the rural area.
2024 Vol. 32 (6): 1252- [Abstract]（
74
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Wang Ruifeng, Wang Jingwen, Wu yan, Zong Junying, Wang Ying
To explore the influence of the anxiety and depression of pregnant women during different stages of pregnancy on their adverse pregnancy outcomes and their infant psychophysical development. Methods: A prospective study cohort was established on the pregnant women from October 2020 to July 2022. The anxiety and depression status of the women were evaluated during the first trimester of pregnancy (≤13 gestational weeks) and during the third trimester of pregnancy (≥28 gestational weeks). The neurobehavioral developments of the infants of the women were evaluated in 1, 3, 6 and 8 months of age of the infants. A total of 387 pregnant women were included for the analysis. Results: The rates of the anxiety and depression of the women during the first trimester of pregnancy were 6.7% and 22.0%, and which of the women during the third trimester were 5.2% and 10.9%. The incidences of the preterm birth and the infant low birth weight of the women with anxiety during the first trimester of pregnancy were significantly higher than those of the normal pregnant women (all P<0.05). The incidences of the infants with growth retardation in the 1st and 3rd month of age and the low weight in the 1st month of age of the women with anxious during the first trimester of pregnancy were significantly higher than those of the normal pregnant women, and the incidence of the infants with growth retardation in the 6th month of age of the women with anxiety during the third trimester of pregnancy was significantly higher than that of the normal pregnant women (all P<0.05). However, there were no significant differences in the infant growth and development indicators between the pregnant women with depression women during different pregnancy stages and the normal pregnant women (all P>0.05). The developmental quotient of gross motor and total motor of the offspring of the women with anxiety during both the first and the third trimester of pregnancy were significantly lower than those of the normal pregnant women. The score of the offspring mental development index (MDI) of the women with anxiety during the third trimester of pregnancy and the women with anxiety during both the first and the third trimester of pregnancy was significantly lower than that of the normal pregnant women (all P<0.05). The developmental quotient of gross motor and total motor of the offspring of the women with depression during the first or the third trimester of pregnancy were significantly lower than those of the normal pregnant women. The developmental quotient of gross motor of the offspring of the women with depression during both the first and the third trimester of pregnancy was significantly lower than that of the normal pregnant women (all P<0.05). Conclusion: The prevalence of the anxiety or depression of the pregnant women during the first trimester of pregnancy is higher that of the women during the third trimester of pregnancy. The anxiety of the women during pregnancy increases the risks of their infants’ preterm birth, low birth weight, and early growth retardation. Both the anxiety and the depression of the women during pregnancy affect the physical and mental development of their infants, therefore, the psychological screening of the women during the first trimester of pregnancy is particularly important, and the early detection and intervention for these women can reduce the impact on the physical and mental development of their infants.
2024 Vol. 32 (6): 1260- [Abstract]（
87
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CHEN Mengquan, SHAN Tingting, ZHENG Wenjieying, CHEN Jun, KONG Wanzhong
To investigate the mutations situation of the sperm mitochondrial DNA cytochrome B (CYTB) gene of patients with asthenozoospermic. Methods: The spermatozoal DNA samples from 134 patients with asthenozoospermic and 129 healthy men were extracted. PCR was performed to the amplification of the mitochondrial DNA CYTB gene, and then the products were sequenced and were compared with the Cambridge Standard Sequence (rCRS). Chi-square test and other methods were used to analyze the mutations of the CYTB gene. Results: The mutations of the mitochondrial DNA CYTB gene were predominantly synonymous and missense. The 15301G/A and 15326A/G heterozygous mutation of the mitochondrial DNA CYTB gene of the patients with asthenozoospermia had increased significantly, and the 15535C/T heterozygous mutation had exclusively found in the normal men, and the differences of which had statistically significant (P<0.05). Conclusion: The mutation of the sperm mitochondrial DNA CYTB of the patients is associated with their asthenozoospermia. The 15301G/A and 15326A/G heterozygous mutation of the mitochondrial DNA CYTB gene of the patients may be the risk factors of their asthenozoospermia occurrence, while the 15535C/T mutation may decrease the risk of their asthenozoospermia.
2024 Vol. 32 (6): 1266- [Abstract]（
65
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ZHOU Xiaohong, SU Aifang
To compare the clinical effect of Yuangong copper-bearing intrauterine device (IUD) and Mirena IUD inserted of women with scar uterus immediately after induced abortion. Methods: 104 women with scar uterine who wanted induced abortion and IUD inserted immediately after induced abortion from June 2022 to June 2023 were selected as the research objects. These women were divided into group A (54 women with Yuangong copper-bearing IUD inserted) and group B (50 women with Mirena IUD inserted). The women in the two groups were followed up 6 months after IUD inserted. The effect of IUD used, the vaginal bleeding situation and the occurrence of adverse reactions of the women were compared between the two groups. Results: The cumulative continuing rates of the women in group B after 1 month (100.0%) and 6 months (90.0%) of IUD inserted had no significantly different from those (98.2% and 81.5%) of the women in group A (P>0.05). The postoperative vaginal bleeding time (5.4±2.3 d) and the vaginal bleeding volume (53.3±10.5 ml) of the women in group B were significantly less than those (7.8±3.1 d, 75.7±11.4 ml) of the women in group A, and the incidence of adverse reactions (8.0%) of the women in group B was significantly lower than that (24.1%) of the women in group A (all P<0.05). Conclusion: The effect of Yuangong copper-bearing IUD and Mirena IUD inserted of the women with scar uterus immediately after induced abortion is similar. Mirena IUD inserted of the women can effectively improve their vaginal bleeding situation and have fewer adverse reactions.
2024 Vol. 32 (6): 1271- [Abstract]（
81
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FAN Jiayi, ZHAO Yalin, WANG Aiwen
To explore the effect of Bushen Yijing decoction combined with estradiol valerate for treating patients with amenorrhea because of premature ovarian failure (POF), and to study its influence on the sex hormones level and ovary of the patients. Methods: 85 patients with amenorrhea because of POF who treated in hospital were selected and were divided into experimental group (n=43) and control group (n=42) by random number table method from January 2021 to January 2023. The patients in the two groups were treated with estradiol valerate, and the patients in the experimental group were treated with Bushen Yijing decoction additionally. The clinical efficacy, the levels of estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the sum value of three diameters of uterus, the endometrial thickness, the average ovarian volume, the TCM symptom score and the rate of complications of the patients were compared between the two groups. Results: The total effective rate (86.1%) of the patients in the experimental group was significantly higher than that (66.7%) of the patients in the control group. The levels of serum E2 of the patients in the two groups had increased signifficantly and the levels of FSH and LH of the patients in the two groups had decreased significantly, and the changes of which (93.25±7.56 pmol/L, 14.13±3.04 U/L and 11.24±2.31 U/L) of the patients in the experimental group were significantly more than those (81.25±8.59 pmol/L, 28.54±4.16 U/L and 20.05±2.34 U/L) of the patients in the control group. The sum value of three uterine diameters, the endometrial thickness and the ovarian average volume of the patients in the two groups had increased significantly, and which (27.41±4.14 cm, 8.69±0.99 mm and 35.71±4.81 mm3) of the patients in the experimental group were significantly higher than those (23.52±4.08 cm, 6.93±0.81) mm and 33.10±4.40 mm3) of the patients in the control group. The scores of the vaginal dryness, the decreased sexual desire, the flank swelling pain and the irritability of the patients in the two groups had decreased significantly, and which of the patients in the experimental group were significantly lower than those of the patients in the control group (all P<0.05). The main adverse reactions of the patients during the treatment included mild nausea and vomiting, and breast pain. The total incidence of the adverse reactions (9.3% vs. 7.1%) of the patients had no significant difference between the two groups (P>0.05). Conclusion: Bushen Yijing decoction combined with estradiol valerate for treating the patients with amenorrhea because of POF can increases the clinical effect, which can better improve the sex hormones level and ovary function of the patients.
2024 Vol. 32 (6): 1275- [Abstract]（
71
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LI Wanle1, WU Qingxia1, FU Xiafei2
To analyze the effect of the vaginal lavage by Anerdian Ⅲ of pregnant women before transfer to cesarean section from vaginal trial delivery for preventing their puerperal infection. Methods: The clinical data of 400 pregnant women with the transfer to cesarean section from vaginal trial delivery between January 2022 and December 2023 were analyzed retrospectively. 200 women in the control group were given vulvar skin preparation and irrigation before cesarean section from January 2022 to December 2022, and 200 women in the observation group were given vulvar skin preparation and vaginal lavage and irrigation by Aliodine III from January 2023 to December 2023. The postoperative body temperature, the 24h blood loss, the puerperal infection rate, the incision infection rate, the white blood cell count (WBC), and the changes of the C-reactive protein (CRP) and procalcitonin (PCT) levels of the women were compared between the two groups. Results: The body temperature values of the women in the observation group at postoperative 24 hours (36.90±0.17℃), 48 hours (36.70±0.15℃) and 72 hours (36.50±0.12℃) were significantly lower than those (37.00±0.21℃, 36.80±0.16℃ and 36.60±0.13℃) of the women in the control group. The amount of bleeding (287.3±21.5ml) of the women in the observation group within 24 hours after operation was significantly less than that (296.2±23.7ml) of the women in the control group. The rate of puerperal infection (0.5%) of the women in the observation group was significantly lower than that (3.5%) of the women in the control group (all P<0.05). There was no significant difference in the incision infection rate (0.5% vs. 1.0%) of the women between the two groups (P>0.05). The WBC (10.07±2.28×109/L) and the levels of CRP (2.23±0.39mg/L) and PCT (4.05±0.62 ng/ml) of the women in the observation group at 72 hours after operation were significantly lower than those (12.77±3.59 ×109/L, 5.06±1.28mg/L and 7.33±1.51ng/ml) of the women in the control group (all P<0.05). Conclusion: The vaginal lavage by Anerdian Ⅲ for the pregnant women before they are transferred to cesarean section from vaginal trial delivery can effectively control their postoperative maternal body temperature, WBC, and CRP and PCT levels, and which can reduce the incidence of the puerperal infection of the women.
2024 Vol. 32 (6): 1279- [Abstract]（
79
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XU Tian1, MA Lan2
To explore the influence of remimazolam mesylate anesthesia during laparoscopic hysterectomy of patients on their inflammatory stress response and cognitive function. Methods: 85 patients who wanted laparoscopic hysterectomy were enrolled and were randomly divided into observation group (46 patients with remimazolam mesylate anesthesia) and control group (39 patients with propofol anesthesia) by the envelope random method from August 2021 to January 2023. The values of hemodynamic indicators, such as heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) before anesthesia (T0), at 5 min after anesthesia (T1), at 10 min after tracheal intubation (T2), immediately after extubation (T3) and at 5 min before the end of surgery (T4), the levels of inflammatory stress indicators, such as interleukin (IL-6), C-reactive protein (CRP), tumor necrosis factor (TNF-α) and norepinephrine (NE), the scores of cognitive ability by Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) at 1 h before surgery and at 12 h after surgery, and the incidence rate of the postoperative adverse reactions of the patients were compared between two groups. Results: The HR values of the patients in the
observation group at T3 (86.6±7.4 times /min) and at T4 (78.6±6.2 times /min) were significantly lower than those (94.1±7.0 times /min and 82.6±6.9 times /min) of the patients in the control group. The SBP value (132.9±7.1mmHg) of the patients in the observation group at T3 was significantly higher than that (128.5±6.8mmHg) of the patients in the control group. The DBP value of the patients in the observation group at T3 (78.6±6.8mmHg) and at T4 (80.3±8.3mmHg) were significantly higher than those (85.6±6.0mmHg and 85.7±8.8mmHg) of the patients in the control group (all P<0.05). The levels of IL-6, CRP, TNF-α and NE (92.87 ±13.75ng/L, 15.61 ±2.99mg/L, 7.42±1.96ng/ml and 74.14 ±11.96ng/L) of the patients in the observation group in 12 hours after operation were significantly lower than those (121.81 ±13.99ng/L, 18.79±3.67mg/L, 8.76 ±2.17ng/ml and 82.57 ±15.53ng/L) of the patients in the control group. The scores of MoCA (29.85±1.66 points) and MMSE (29.46±1.11 points) of the patients in the observation group in 3 days after surgery were significantly higher than those (28.92±1.36 points and 28.62±1.06 points) of the patients in the control group. The incidence of the adverse reactions (19.6%) of the patients in the observation group was significantly lower than that (41.0%) of the patients in the control group (all P<0.05). Conclusion: Remimazolam mesylate anesthesia during laparoscopic hysterectomy of the patients has the effect of stabilizing their hemodynamics, improving their inflammatory stress load and protecting their cognition.
2024 Vol. 32 (6): 1283- [Abstract]（
57
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DING Chenghong1, DENG Xiaomei2, XU Fengqin1, WANG Yanfeng1, KONG Lingling1
To investigate the effects of applying arginine human insulin injection for treating pregnant women with gestational diabetes mellitus (GDM) on their levels of hemoglobin (HGB), C-reactive protein (CRP), C-peptide (CP) and blood glucose, and their safety. Methods: 106 pregnant women with GDM who were admitted to hospital were selected and were divided into control group and observation group (53 cases in each group) by the two-color grouping method from December 2020 to December 2023. The women in the two groups were given the treatment of insulin aspart for treating their GDM for 2 months, the women in the control group were given the treatment of menthol insulin additionally and the women in the observation group were given the treatment of arginin-synthesized human insulin injection additionally. The levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c) and 2 h postprandial glucose (2h PG) and fasting insulin (FINS) of the women in the two groups before and after treatment were detected. The homeostasis model assessment of insulin resistance (HOMA-IR) value of the women in the two groups was calculated. The levels of the HGB, CP, CRP and interleukin-6 (IL-6) of the women in the two groups were also detected. The adverse pregnancy outcomes of the women in the two groups were collected. Results: The levels of FBG, HbAlc, 2hPG, HGB, CRP and IL-6, and the HOMA-IR value of the women in both groups after 2 months of treatment had decreased significantly, and which (4.06±0.28 mmol/L, 4.15%±0.26%, 5.05±0.36 mmol/L, 134.79±5.32 g/L, 5.01±0.12 mg/L, 6.33±0.70 ng/ml and 2.29±0.47) of the women in the observation group were significantly lower than those (5.11±0.48 mmol/L, 5.31%±0.56%, 6.46±0.38mmol/L, 138.12±9.95g/L, 6.96±0.34mg/L, 7.59±0.82ng/ml and 2.52±0.56) of the women in the control group. The levels of FINS and CP of the women in both groups had increased significantly, and which (8.61±0.38 mU/L and 1.90±0.26mg/L) of the women in the observation group were significantly higher than those (7.89±0.31mU/L and 1.67±0.22 mg/L) of the women in the control group. The incidence of the adverse pregnancy outcomes (11.3%) of the women in the observation group was significantly lower than that (32.1%) of the women in the control group (P<0.05). Conclusion: The insulin aspart combined with arginine human islet injection for treating the pregnant women with GDM can effectively improve their blood glucose level, elevate their HGB and CP levels, and reduce their levels of inflammatory factors and adverse pregnancy outcomes, and with the higher clinical effectiveness and safety.
2024 Vol. 32 (6): 1290- [Abstract]（
78
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YU Yingchun1, JI Chunmin1, LI Rong2, YANG Xiulan3
To investigate the efficacy of goserelin combined with mifepristone for treating patients with uterine fibroids, and to study its influence on the levels of serum sex hormones, transforming growth factor β1 (TGF-β1) and tumor specific growth factor(TSGF) of the patients. Methods: A total of 160 patients with uterine fibroids admitted to hospital were collected and randomly divided into two groups from May 2022 to October 2023. 80 patients in the control group received treatment of mifepristone for 6 months continuously, and 80 patients in the observation group received treatment of goserelin combined with mifepristone for 6 months continuously. The clinical therapeutic effect and the levels of sex hormones, TGF- β 1 and TSGF, and the endometrial thickness of the patients before and after treatment were compared between the two groups. Results: The total effective rate (91.3%) of the patients in the observation group was significantly higher than that (80.0%) of the patients in the control group. The levels of progesterone (3.12±1.05 μmol/L), testosterone (0.89±0.27 μmol/L), prolactin (12.01±3.41 μg/L), TGF-β1 (10.98±2.59 ng/L) and TSGF (27.86±7.84μmol/L), and the values of uterine volume (176.42±94.51 cm3), fibroid volume (28.09±9.51 cm3) and endometrial thickness (0.87±0.05 cm) of the patients in the observation group were significantly lower than those (4.67±1.87μmol/L, 1.96±0.89μmol/L, 15.42±3.98μg/L, 12.43±2.76 ng/L, 34.72±9.85μmol/L, 209.88±98.75 cm3, 32.43±9.84 cm3 and 0.94±0.09 cm) of the patients in the control group (all P<0.05). There was no significant difference in the adverse reactions rate (18.8% vs. 15.0%) of the patients between the two groups (P>0.05). Conclusion: Both mifepristone and goserelin has the effect for treating the patients with uterine fibroids, but goserelin combined with mifepristone has better effect, and which can regulate the sex hormones levels, reduce the TGF- β1 and TSGF levels, and decrease the uterus volume, fibroid volume and endometrial thickness of the patients, and without increasing the adverse reactions.
2024 Vol. 32 (6): 1295- [Abstract]（
88
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ZHANG Haixia, HU Rongrong, BI Jingjing
To explore the correlation between the disease uncertainty of couples with in vitro fertilization-embryo transfer (IVF-ET) and their fertility stress and mental toughness. Methods: 80 couples with IVF-ET were selected in this study from January 2023 to December 2023. These couples were investigated by the general information questionnaire. Mishel uncertainty in illness scale (MUIS), fertility pressure inventory (FPI) and the Chinese version of conner Davidson-resilience scale (CD-RISC) were used to investigation and evaluation. The scores of each dimension of these scales were compared between wife and husband. The differences of the total scores of MUIS, FPI and CD-RISC of the couples with different assisted pregnancy cycles of IVF-ET were analyzed. Pearson correlation was used to analyze the correlation among the total scores of these scales. Results: A total of 160 questionnaires of 80 couples with IVF-ET were issued and 152 valid questionnaires from 76 couples were recovered, with an effective rate of 95.0%. The total score of MUIS of the wives (95.91±12.28 points) had no significantly different from that (95.67±11.89 points) of their husbands, and there was no significant difference in the MUIS score among the couple with different assisted pregnancy cycles and among the couple with different assisted pregnancy results (all P>0.05). The total scores of FPI and CD-RISC of the wives (151.24±30.18 points and 61.38±10.76 points) were significantly different from those (138.10±31.37 points and 66.54±11.00 points) of their husbands (P<0.05). The FPI score of the wives with 1 cycle of assisted pregnancy was significantly lower than that of the wives with ≥3 cycles of assisted pregnancy, and the CDRISC score of the wives with 1 cycle or 2 cycle of assisted pregnancy was significantly higher than that of the wives with ≥3 cycles of assisted pregnancy (all P<0.05). There was no significant difference in the MUIS score among the wives with different assisted reproductive cycles, and there were no significant differences in the MUIS and FIP scores of the wives with different assisted reproductive outcomes. There were no significant differences in the total scores of MUIS and FIP among the husbands with different assisted reproductive cycles and outcomes (all P>0.05). The total MUIS FPI score of the wives was positively correlated with the total MUIS score of the husbands and the total score of the wife/husband, and was negatively correlated with the total CD-RISC score of the wife/husband. The total MUIS score of the husbands was positively correlated with the total FPI score of the wife/husband, and was negatively correlated with the total CD-RISC score of the wife/husband (all P<0.05). Conclusion: The situations of uncertainty in illness and fertility stress of the couples with IVF-ET in this survey are in the medium levels, and the psychological resilience of the couples is in the general level. The fertility stress and psychological resilience of the wives are worse than their husbands. The disease uncertainty of the couples was related to their fertility stress and psychological resilience.
2024 Vol. 32 (6): 1300- [Abstract]（
65
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ZHAO Ni, XIANG Xuewen, ZHAO Na, PENG Xianxiu
To explore the influence of myofascial finger method combined with neuromuscular electrical stimulation for treating patients with chronic pelvic pain syndrome (CPPS) on the changes of their inflammatory indicators levels, pelvic floor electromyography and anorectal pressure. Methods: 197 patients with CPPS were selected and were divided into group A (98 cases with the treatment of neuromuscular electrical stimulation) and group B (99 cases with the treatment of finger method combined with neuromuscular electrical stimulation) according to the random number table method from March 2022 to May 2023. The levels of inflammatory indicators, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), and the situations of pelvic floor electromyography, anorectal pressure and pain recovery of the patients were compared between the two groups. Results: The levels of CRP, IL-6 and TNF-α of the patients in the two groups after treatment had decreased significantly, and which (7.56±2.42 pg/ml, 252.14±146.17 mg/L and 1.92±0.56 ng/L) of the patients in group B were significantly lower than those (9.45±2.57 pg/ml, 381.58±147.59 mg/L and 2.48±0.63 ng/L) of the patients in group A. The levels of CRP, IL-6 and TNF-α of the patients in the two groups in the before and after resting phase had decreased significantly, and which of the patients in group B were significantly lower than those of the patients in group A. The levels of CRP, IL-6 and TNF-α of the patients in the two groups in the five times of rapid contraction phase, 10s sustained contraction phase and 60s sustained contraction phase had increased significantly, and which of the patients in group B were significantly higher than those of the patients in group A. The values of rectal pressure and the anal maximum systolic pressure of the patients in the two groups had increased significantly, and which (6.32±0.76 kPa and 25.15±2.32 kPa) of the patients in group B were significantly higher than those (5.78±0.47 kPa and 23.89±2.43 kPa) of the patients in group A. The values of the defecation sensation threshold and anal resting pressure of the patients in the two groups had decreased significantly, and which (55.84±6.06ml and 8.39±2.25 kPa) of the patients in group B were significantly lower than those (61.49±7.17ml and 11.32±3.41 kPa) of the patients in group A. The rate of severe pain (5.1%) of the patients in group B was significantly lower than that (10.2%) of the patients in group A (all P<0.05). Conclusion: The myofascial finger method combined with neuromuscular electrical stimulation for treating the patients with CPPS can better effectively reduce their inflammatory response, relieve their tension of pelvic floor muscle, restore their pelvic floor function and relieve their pain degree.
2024 Vol. 32 (6): 1306- [Abstract]（
60
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SHEN Menghua, CUI Jing, WANG Zhengzheng, YANG Haimin
To explore the effects of intraoperative risk management combined with perioperative psychological support for patients with gynecological laparoscopic surgery on their rehabilitation. Methods: A total of 102 patients with uterine fibroids or ovarian cysts who wanted gynecological laparoscopic surgery were included and were divided into two groups (51 cases in each group) by random number table method from January 2022 to December 2023. The patients in the two groups were given routine care. The patients in the intervention group were given intraoperative risk management combined with perioperative psychological support additionally. The postoperative gastrointestinal function recovery indexes, the complications, the scores of postoperative pain by visual analogue scale (VAS), Hamilton depression scale (HAMD), generalized anxiety disorder Self-rating scale (GAD-7), exercise of self-care Agency scale (ESCA) and health promoting lifestyle profile-Ⅱ(HPLP-Ⅱ), and the satisfaction for the intervention of the patients in the two groups were observed. Results: The related indexes of the gastrointestinal function recovery of the patients in the intervention group were significantly shorter than those of the patients in the control group. The incidence of postoperative complications (2.0%) of the patients in the intervention group was significantly lower than that (13.7%) of the patients in the control group. The VAS scores of the patients the intervention group in postoperative 1, 4 and 7 days (4.03±0.26 points, 1.35±0.32 points and 0.41±0.08 points) of the patients in the intervention group were significantly lower than those (4.74±0.34 points, 2.01±0.29 points and 0.85±0.12 points) of the patients in the control group. The scores of HAMD (11.52±1.85 points), GAD-7 (10.06±1.85 points), ESCA (122.49±2.85 points) and HPLP-Ⅱ (168.45±7.34 points) of the patients in the intervention group after intervention were significantly better than those (14.95±2.12 points, 12.35±2.05 points, 118.65±3.23 points and 142.35±8.45 points) of the patients in the control group. The intervention satisfaction of the patients in the intervention group was significantly higher than that of the patients in the control group (all P<0.05). Conclusion: Intraoperative risk management combined with perioperative psychological support for the patients with gynecological laparoscopic surgery can promote their postoperative gastrointestinal function recovery, reduce their postoperative complications, improve their psychological state, enhance their self-care ability and help their developing the healthy behaviors, which is conducive to the postoperative recovery of the patients, and with higher satisfaction.
2024 Vol. 32 (6): 1312- [Abstract]（
67
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ZHANG Jianfei1, JIN Bingxin2
To explore the application of ketamine combined with propofol and remifentanil transversus abdominis plane block (TAPB) during gynecological laparoscopic surgery of patients, and to study its impact on the postoperative pain and rehabilitation of the patients. Methods: 100 patients who wanted laparoscopic surgery admitted to the gynecology department of the hospital were selected and were randomly divided into two groups (50 cases in each group) from January 2021 to December 2023. The patients in group A received propofol and remifentanil TAPB anesthesia, while the patients in group B received ketamine combined with propofol and remifentanil TAPB anesthesia. The dosage of anesthetics (propofol and remifentanil), the recovery quality, such as the extubation time and the stay time in the recovery room, the postoperative pain evaluated by VAS score, the recovery indicators, such as the exhaust time, the time of getting out of bed and the duration of the postoperative hospital stay, the levels of serological indicators, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and neuronspecific enolase (NSE), and the adverse reactions rate of the patients in the two groups were observed. Results: The dosages of intraoperative propofol used (402.69±27.27 mg) and remifentanil (1.21±0.19 mg), the extubation time (12.06±2.10 min) and the stay time in the recovery room (30.66±6.41 min) of the patients in group B were significantly less than those (425.24±30.68 mg, 1.60±0.25 mg, 17.35±2.73 min and 35.29±7.23 min) of the patients in group A. The VAS scores of the patients in group B at postoperative 2h, 6h, 12h, 24h and 48h were significantly lower than those of group A. The time of exhaust (30.62±5.78 h), the time of getting out of bed (35.50±6.21 h) and the duration of the postoperative hospital stay (4.96±1.00 d) of the patients in group B were significantly less than those (36.41±6.15 h, 42.14±6.93 h and 5.61±1.14 d) of the patients in group A. The levels of IL-6, TNF-α and NSE of the patients in the two groups in postoperative 1 day were significantly higher than those before operation, but which of the patients in group B were significantly lower than those of the patients in group A. The incidence of adverse reactions (6.0%) of the patients in group B was significantly lower than that (20.0%) of the patients in group A (all P<0.05). Conclusion: Ketamine combined with propofol and remifentanil TAPB used during gynecological laparoscopic surgery of the patients has better anesthetic effect, which can reduce the amount of their anesthesia maintenance medication, improve their awakening quality, alleviate their postoperative pain, aid their postoperative rehabilitation, improve their serological indicators and reduce their adverse reactions.
2024 Vol. 32 (6): 1317- [Abstract]（
68
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LIU Fei
To explore the postoperative analgesic effect comparison of ultrasound-guided ropivacaine quadratus lumborum block (QLB) or transversus abdominis plane block (TAPB) during cesarean section of puerperae. Methods: 142 puerperae who wanted cesarean section were selected and were divided into two groups (71 cases in each group) according to the different anesthesia methods from January 2023 to July 2023. The puerperae in the two groups were all given spinalepidural anesthesia during cesarean section. The puerperae in group A were injected with ropivacaine into quadratus lumborum and the puerperae in group B were injected with ropivacaine between obliquus internus abdominis and transversus abdominis. The analgesic effect evaluated by VAS score, the comfort evaluated by comfort score, the clinical activities situation at different time points (at postoperative 4, 8, 12, 24 and 48 h), the consumption of sedatives in 2d after surgery and the incidence rates of postoperative adverse reaction of the puerperae were compared between the two groups. Results: There was no significant difference in the scores of VAS and comfort of the puerperae at postoperative 4h and 8h between the two groups (P>0.05). The VAS scores of the puerperae in group A at postoperative 12h, 24h and 48h (2.25±0.33 points, 2.05±0.52 points and 1.82±0.34 points) were significantly lower than those (2.42±0.40 points, 2.23±0.43 points and 1.93±0.30 points) of the puerperae in group B. The comfort scores of the puerperae in group A at postoperative 12h, 24h and 48h (2.29±0.23 points, 2.52±0.22 points and 2.76±0.32 points) were significantly higher than those (2.16±0.30 points, 2.30±0.29 points and 2.51±0.30 points) of the puerperae in group B (all P<0.05). There was no significant difference in the first sitting time and eating time of the puerperae between the two groups (P>0.05). The first standing time (5.34±1.26h) and the walking time (7.42±1.71h) of the puerperae in group A were significantly shorter than those (6.25±1.35h and 9.06±2.30h) of the puerperae in group B. The consumption of sedatives (38.50±5.63μg) of the puerperae in group A was significantly less than that (77.23±7.85μg) of the puerperae in group B, and the incidence of adverse reactions (11.3%) of the puerperae in group A was significantly lower than that (25.4%) of the puerperae in group B (all P<0.05). Conclusion: Both ropivacaine QLB and ropivacaine TAPB during cesarean section of the puerperae can provide their effective postoperative analgesia. The ropivacaine QLB has more obvious advantages in the analgesia time and effect, and the reduction of adverse reactions of the puerperae.
2024 Vol. 32 (6): 1322- [Abstract]（
74
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LIU Yang, WANG Dongying, SUN Li
To explore the influence of the different humidity in the incubator on the weight of premature infants. Methods: From March 2022 to September 2023, 100 premature infants (less than 37 gestational weeks) were selected and were divided into two groups (50 cases in each group) by random number table method. The neonates in the two groups were given care with different humidity in the incubator, including the neonates in the observation group with the humidity of 85%- 90% within 1 week after birth and the neonates in the control group with normal humidity of 55%-65%. The weight change of the neonates within 1 week after birth, the time of weight recovery and the complications rate of the neonates in the two groups were recorded. The score of neonatal skin condition rating scale (NSCS) of the neonates was compared between the two groups. Results: The weight loss of the neonates (32.8±10.3g) in the observation group on the 3rd day after birth was significantly less than that (43.1±13.8g) of the neonates in the control group. The weight gain (40.6±12.7g) in the observation group on the 7th day after birth was significantly more than that (30.5±9.0g) of the neonates in the control group. The scores of the skin dryness (1.45±0.31 points) and the skin damage (1.20±0.37 points), and the total score (3.83±1.02 points) evaluated by NSCS scale of the neonates in the observation group were significantly lower than those (1.70±0.25 points, 1.40±0.28 points and 4.43±0.95 points) of the neonates in the control group. The average daily weight gain (19.1±5.7g) of the neonates in the observation group during hospitalization was significantly higher than that (15.6±4.2g) of the neonates in the control group. The time to the weight return to the birth weight (6.00±1.45d) and the hospital stay (15.60±5.13 d) of the neonates in the observation group were significantly shorter that those (7.39±1.50 d and 18.67±5.97 d) of the neonates in the control group (all P<0.05). There were no significant differences in the incidences of pneumonia, upper respiratory tract infection, skin infection, diarrhea and thrush, and the total incidence of nosocomial infection of the neonates between the two groups (P>0.05). Conclusion: Appropriately increasing the ambient humidity of the premature infants in the infant incubator can slow their early weight loss, promote their weight gain, reduce their risk of skin damage, and without increasing the risk of infection, which is conducive to the growth and development of the premature infants.
2024 Vol. 32 (6): 1326- [Abstract]（
71
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QI jiaqi1,2, ZHANG Zidong2, JU Yanmei2, GAO Jie2, WAMG Jinping1
To investigate the effects of dexmedetomidine combined with ropivacaine for quadratus lumborum block (QLB) during laparoscopic myomectomy (LM) of patients on their stress and postoperative recovery. Methods: 80 patients who wanted LM admitted to the obstetrics and gynecology department of the hospital were randomly divided into group A and group B (40 patients in each group) from January 2023 to December 2023. The patients in group A were given ropivacaine for QLB, while the patients in group B given dexmedetomidine combined with ropivacaine for QLB. The postoperative pain evaluated by VAS score, the levels of stress response indicatiors, such as cortisol and norepinephrine, the cognitive function evaluated by MMSE score, the sleep quality evaluated by PSQI score, the time of postoperative recovery, such as the exhaust time, the time of getting out of bed and the duration of hospitalization stay, and the situation of adverse reactions, such as nausea and vomiting, dizziness, drowsiness and itching, of the patients in the two groups were observed. Results: The VAS scores of the patients in group B at 2h, 6h, 12h and 24h after operation (1.02±0.24 points, 1.63±0.48 points, 2.01±0.72 points and 3.06±0.70 points) were significantly lower than those (1.15±0.36 points, 1.95±0.60 points, 2.62±0.85 points and 3.77±0.76 points) of the patients in group A. The levels of cortisol and norepinephrine of the patients in both groups at 24 hours after operation had increased significantly, but which (165.17±48.25 ng/ml and 322.15±53.83 ng/L) of the patients in group B were significantly lower than those (189.25±51.03 ng/ml and 345.23±45.90 ng/L) of the patients in group A. The MMSE score of the patients in both groups at 24 hours after operation had decreased significantly and the PSQI score of the patients in both groups at 24 hours after operation had increased significantly, but the MMSE score (27.05±1.19 points) of the patients in group B was significantly higher than that (25.62±1.48 points) of the patients in group A and the PSQI score (16.23±1.56 points) of the patients in group B was significantly lower than that (18.00±1.68 points) of the patients in group A. The time of the postoperative exhaust (25.86±5.12 h), the time of getting out of bed (1.88±0.69 d) or the duration of hospital stay (6.01±1.60 d) of the patients in group B was significantly shorter than that (33.57±6.34 h, 2.65±0.75 d or 7.32±1.78 d) of the patients in group A (all P<0.05). There was no significant difference in the incidence of the adverse reactions (15.0% vs. 12.5%) of the patients between the two groups (P>0.05). Conclusion: The combination of dexmedetomidine and ropivacaine for QLB during LM of the patients has better anesthetic effect, and can reduce the postoperative pain and stress reactions, improve the cognitive function and the sleep quality of the patients, and which is beneficial for the postoperative recovery with the safety of medicine.
2024 Vol. 32 (6): 1331- [Abstract]（
67
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WANG Xueping1, YIN Yanni1, WANG Jiebing1, CAI Xiaopan1, CHEN Tao2
To explore the effects of preemptive analgesia by flurbiprofen ester during hysteroscopic surgery of patients on their indexes of postoperative pain and inflammation response. Methods: A total of 138 patients who wanted hysteroscopic surgery were selected and were divided into two groups (69 cases in each group) according to random odd-even method from January 2022 to January 2024. The patients in the control group were given general anesthesia, and the patients in the observation group were given preemptive analgesia by flurbiprofen ester combined with the general anesthesia. The levels of intraoperative hemodynamic indexes, the anesthetic effect, the postoperative pain score, the inflammation indexes levels and the adverse reactions rate of the patients were compared between the two groups. Results: The values of heart rate (HR) and mean arterial pressure (MAP) of the patients in both groups at the time of cervical dilation (T1) and before the completion of operation (T2) were significantly higher than those of the patients before anesthesia induction treatment (T0), and the values of HR and MAP of the patients in the observation group at T1 and T2 were significantly lower than those of the patients in the control group. The dosage of propofol used (213.28±2.43 mg) and the wake-up time (3.12±0.75 min) of the patients in the observation group were significantly less than those (248.83±2.17 mg and 7.53±1.22 min) of the patients in the control group. The pain scores of the patients in the observation group at 2h, 12h and 24h after operation (1.53±0.36 points, 2.49±0.74 points and 1.86±0.53 points) were significantly lower than those (3.72±0.65 points, 4.65±1.18 points and 3.51±0.62 points) of the patients in the control group. The levels of serum interleukin-6, prostaglandin E2, tumor necrosis factor-α and substance P of the patients in the observation group were significantly lower than those of the patients in the control group (all P<0.05). There was no significant difference in the incidence of adverse reactions (5.8% vs. 10.1%) of the patients between the two groups (P<0.05). Conclusion: Preemptive analgesia by flurbiprofen ester during hysteroscopic surgery of the patients can help reduce their postoperative pain and inflammatory responses, and improve their clinical effect, and with the medication safety.
2024 Vol. 32 (6): 1336- [Abstract]（
69
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QIN Jun, DONG Xiangyu
To investigate the anesthesia and effect of ultrasound-guided anterior block of superior arcuate ligament quadrate musculi lumbosum combined with general anesthesia during laparoscopic total hysterectomy of patients. Methods: From April 2023 to December 2023, 102 patients who wanted laparoscopic total hysterectomy in the hospital were selected and were randomly divided into two groups (51 cases in each group). The patients in the control group were given general anesthesia with simple intubation during surgery and the patients in the observation group were given ultrasound-guided anterior block of quadrate lumbosi muscle superior arcuate ligament combined with general anesthesia. The dosages of remifentanil and propofol used during operation, the degree of pain at different time points after operation, the frequency of analgesic drug used, the stress response and the adverse reactions rate of the patients were recorded and were compared between the two groups. Results: The dosages of remifentanil (1.76±0.27 mg) and propofol (241.33±27.55 mg) of the the patients in the observation group were significantly lower than those (1.96±0.26 mg and 295.63±26.95 mg) of the patients in the control group. The postoperative visual analogue scale (VAS) score at resting state, the number of postoperative analgesics used and the values changes of mean arterial pressure (MAP) and heart rate (HR) of the patients in the observation group were significantly lower than those of the patients in the control group (P<0.05). There was no significant difference in the postoperative adverse reaction rate (9.8% vs. 15.7%) of the patients between the two groups (P>0.05). Conclusion: Ultrasound-guided anterior block of superior arcuate ligament quadrate musculi lumbosum combined with general anesthesia during laparoscopic total hysterectomy of the patients can effectively reduce the dosages of the anesthesic drugs used, improve the postoperative pain, reduce the number of emedial analgesics and alleviate surgical stress reactions of the patients, and with good safety.
2024 Vol. 32 (6): 1341- [Abstract]（
87
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JI Miao, DENG Xuefeng, LIU Qin, ZHANG Ding, YIN Yingying, WU Yan
To explore the effects of esketamine used during gynecological laparoscopic surgery of patients on their surgical indicators, pain situation, pain threshold, pain sensitive area, sufentanil dosage and safety. Methods: A total of 94 patients with lesions in uterus or ovarian who wanted laparoscopic lesions ectomy under general anesthesia were selected and were divided into two groups (47 patients in each group) according to random number table method from September 2022 to December 2023. The patients in the study group were injected with esketamine before anesthesia induction, and the patients in the control group were injected with the same amount of normal saline before anesthesia induction. The surgical indexes, the conditions of static and dynamic pain before and after operation, the pain sensitivity threshold and the area of the mechanical pain sensitivity of the incision, and the adverse reactions rate of the patients were compared between the two groups. Results: The eye opening time (12.11±1.38 min) and the tracheal tube removal time (14.89±2.46 min) of the patients in the study group were significantly lower than those (13.24±1.69 min and 16.03±2.51 min) of the patients in the control group. The static and dynamic visual analogue scores (1.57±0.87 points and 2.06±1.04 points) of the patients in the study group were significantly lower than those (2.23±1.09 points and 2.74±1.18 points) of the patients in the control group. The mechanical hyperalgesia thresholds of the incision and the medial arm (52.03±8.29g and 54.87±8.34g) of the patients in the study group were significantly higher than those (40.56±7.62g and 43.55±7.68g) of the patients in the control group. The mechanical hyperalgesia area of the incision and medial arm (52.36±6.55 cm2 and 50.21±6.94 cm2) in the study group were significantly lower than those (64.18±7.69 cm2 and 63.42±7.58 cm2) of the patients in the control group. The dosage of sufentanil used in postanesthesia care unit (PACU) (17.16±2.31μg), at 6h after discharge (19.24±3.10μg) and at 18h after discharge (16.13±2.57μg) of the patients in the study group were significantly lower than those (19.54±3.14μg, 22.79±3.58μg and 16.13±2.57μg) of the patients in the control group. The incidence of the adverse reactions (12.8%) of the patients in the study group was significantly lower than that (34.0%) of the patients in the control group (all P<0.05). Conclusion: Esketamine used during gynecological laparoscopic surgery of the patients can effectively inhibit their postoperative hyperalgesia, improve their operation recovery indexes, and decrease their adverse reaction, and with better safety.
2024 Vol. 32 (6): 1345- [Abstract]（
74
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LIU Yang, LIU Xin, WANG Dongying
To study the effects of whole-person care in mechanical ventilation treatment of premature infants with respiratory distress syndrome (RDS) on their blood gas and lung oxygenation. Methods: 92 premature infants with RDS treated in hospital were selected and were divide into control group (46 cases with routine nursing intervention) and observation group (46 cases with whole-person care intervention combined with routine nursing intervention) by random number table method from September 2022 to September 2023. The severity of disease, the lung injury situation, the values of blood gas indexes, the respiratory dynamics, the pulmonary oxygenation function and the incidence rate of complications were compared between the two groups. Results: The total proportion of the infants with critically ill in the two groups after intervention had decreased significantly, and which (39.1%) of the infants in the observation group was significantly lower than that (65.2%) of the infants in the control group. The lung injury score of the infants in the two groups had decreased significantly, and which (39.1%) of the infants in the observation group was significantly lower than that (65.2%) of the infants in the control group. The values of arterial oxygen partial pressure and blood oxygen saturation of the infants in the two groups had increased significantly, and which (82.39±3.07 mmHg and 96.86%±0.78%) of the infants in the observation group were significantly higher than those (80.18±3.14 mmHg and 96.38%±0.83%) of the infants in the control group. The arterial carbon dioxide partial pressure value of the infants in the two groups had decreased significantly, and which (40.15±1.57 mmHg) of the infants in the observation group was significantly lower than that (41.02±1.43 mmHg) of the infants in the control group. The values of peak inspiratory pressure and thoracic lung compliance of the infants in the two groups had increased significantly, and which of the infants in the observation group were significantly higher than those of the infants in the control group. The respiratory rate of the infants in the two groups had decreased significantly, and which (22.15±0.58 times /min) of the infants in the observation group was significantly lower than that (22.54±0.49 times /min) of the infants in the control group. The respiratory index and oxygenation index of the infants in the two groups had decreased significantly, and which (6.48±1.37 and 1.59±0.34) of the infants in the observation group were significantly lower than those (7.31±1.25 and 1.84±0.31) of the infants in the control group. The incidence of complications (2.2%) of the infants in the observation group was significantly lower than that (13.0%) of the infants in the control group (all P<0.05). Conclusion: Whole-person care in mechanical ventilation treatment of the premature infants with RDS can reduce their severity of disease, improve their lung injury, blood gas indexes, respiratory function and pulmonary oxygenation function, and which can reduce the occurrence of the complications of the infants.
2024 Vol. 32 (6): 1350- [Abstract]（
64
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QIN Wei, WU Longyan
To explore the effects of the postural support, non-nutritive sucking (NNS) and gentle touching for neonates on their pain during venipuncture for the collection of blood. Methods: 186 neonates who needed femoral venipuncture for the collection of blood in the hospital were enrolled and were divided into observation group (93 cases with the postural support, NNS and gentle touching) and the control group (93 cases with routine position and touching) according to random number table method between June 2021 and June 2022. The heart rate and the respiratory rate before and after venipuncture, the scores of the neonatal infant pain scale (NIPS) at 1 and at 5min after venipuncture, the success rate of the first venipuncture, the blood collection time and the adverse reactions occurrence of the neonates were compared between the two groups. Results: The heart rate (122.37±15.30 times/min) and the respiratory rate (44.53±5.57 times/min) of the neonates in the observation group were significantly lower than those (143.31±17.91 times/min and 56.29±7.04 times/min) of the neonates in the control group. The NIPS scores of the neonates in the observation group at 1min and at 5min after venipuncture (4.29±0.89 points and 1.67±0.25 points) were significantly lower than those (5.53±1.13 points and 3.09±0.71 points) of the neonates in the control group. The first success rate of blood collection by venipuncture (95.7%) of the neonates in the observation group was significantly higher than that of the neonates in the control group (85.0%). The time of the blood collection (1.13±0.17 min) of the neonates in the observation group was significantly shorter than that (1.32±0.22 min) of the neonates in the control group, and the incidence of adverse reactions after venipuncture (12.9%) of the neonates in the observation group was significantly lower than that (28.0%) of the neonates in the control group (all P<0.05). Conclusion: The application of the postural support, NNS and gentle touching during the blood collection by venipuncture of the neonates can relieve their pain degree, increase their first success rate of blood collection by venipuncture and shorten their blood collection time.
2024 Vol. 32 (6): 1356- [Abstract]（
62
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ZHU Hongyan, ZHU Taoyan
To explore the influence of the targeted nutrition guidance for primipara in the whole perinatal period on their delivery. Methods: A total of 103 primiparas were included and were divided into control group (51 cases) and observation group (52 cases) by random number table method from April 2020 to June 2023. The primiparas in the control group received routine perinatal obstetric care intervention, and the primiparas in the observation group received targeted nutrition guidance intervention in the whole perinatal period additionally. During the intervention, 1 case in each group was fallen off. The total labor duration, the 2h postpartum blood loss, the rates of natural delivery and the maternal and neonatal complications, the score of the maternal pain score during delivery evaluated by VAS, the scores of Edinburgh Postpartum Depression Scale (EPDS) and Conner-Davidson Flexibility Scale (CD-RISC), the maternal nutrition status and the satisfaction for the intervention of the primiparas in the two groups were observed. Results: The duration of the total labor (431.49±24.19 min) and the amount of postpartum hemorrhage (123±10 ml) of the primiparas in the observation group were significantly less than those (508.18±22.17 min and 204±11 ml) of the primiparas in the control group. The natural delivery rate (80.4%) of the primiparas in the observation group was significantly higher than that (60.0%) of the primiparas in the control group. The rates of maternal complications (0) and the neonatal complications (3.9%) in the control group were significantly lower than those (8.0% and 16.0%) of the primiparas in the control group. The VAS score (4.85±0.94 points) of the primiparas in the observation group at delivery was significantly lower than that (6.23±0.56 points) of the primiparas in the control group. The scores of EPDS (7.29±0.69 points) and CD-RISC (81.27±4.27 points) of the primiparas in the observation group in 3 days after delivery were significantly better than those (9.13±0.77 points and 77.62±2.65 points) of the primiparas in the control group. The incidence of malnutrition (0) of the primiparas in the observation group was significantly lower than that (8.0%) of the primiparas in the control group, and the maternal satisfaction rate for the intervention (94.1%) of the primiparas in the observation group was significantly was higher than that (78.0%) of the primiparas in the control group (all P<0.05). Conclusion: Targeted nutrition guidance for the primiparas in the whole perinatal period can better improve their nutritional status, reduce their incidence of malnutrition, shorten their total labor process, reduce their postpartum hemorrhage and complications rate, relieve their pain during delivery, improve their natural delivery rate, and with the good postpartum psychological state and high satisfaction rate of the primiparas.
2024 Vol. 32 (6): 1360- [Abstract]（
64
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LI Qiaolan1,2, WU Dan2, WANG Luya2
To explore the effect of the postpartum pelvic floor (PF) function rehabilitation of the pelvic floor muscle exercise (PFME) combined with the bionic electrical stimulation (BES) for treating puerperae with vaginal delivery (VD). Methods: The clinical data of 102 puerperae with VD and postpartum pelvic floor dysfunction from December 2021 to December 2023 were analyzed retrospectively. According to the different treatment regimens, these puerperae were divided 53 puerperae with treatment of PFME in control group and 49 puerperae with treatment of PFME combined with BES in observation group. The puerperae in both groups were begun to treat in 42-50 days after delivery and were continued treatment for 1 month. The PF muscle strength by Oxford pressure hand test, the electromyography amplitude of PF muscle, the fatigue degree of PF muscle evaluated by pelvic floor electromyography variation coefficient and the ultrasound parameters of PF muscle, such as bladder neck mobility and urethral rotation angle, of the puerperae before and after treatment were compared between groups. Results: The parameters values of PF muscle of the puerperae in the two groups after treatment had improved significantly, and the PF muscle strength (3.37±1.02) of the PF muscle of the puerperae in the observation group was significantly higher than that (2.98±0.88) of the puerperae in the control group and the potential activity value of the PF muscle in the observation group was also significantly higher. The degree of the pelvic PF fatigue of the puerperae in the observation group was significantly lower than that of the puerperae in the control group, and the bladder neck mobility (12.47±3.34 mm) and the urethral rotation angle (25.65±6.90°) of the puerperae in the observation group were significantly lower than those (14.39±3.70 mm and 29.26±7.21°) of the puerperae in the control group (all P<0.05). Conclusion: PFME combined with BES for treating the puerperae with VD can effectively restore their PF muscle systolic function, enhance their PF muscle tension and improve their PF muscle fatigue and can correct the structure of their bladder neck and urethra construction, and thus can relieve their PF muscle disorder.
2024 Vol. 32 (6): 1364- [Abstract]（
61
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XU Lixia, SU Aifang, ZHU Ling, HU Qingyue
To explore the long-term therapeutic efficacy of the home-based training combined with sacral nerve magnetic stimulation (SNMS) and pelvic floor muscle rehabilitation training (PFMRT) for treating patients with chronic pelvic pain (CPP). Methods: From June 2022 to June 2023, 100 patients with CPP were selected and were divided into two groups (50 cases in each group) by random number table method. 10 patients in the control group had dropped out, so finally, 40 patients were included in the control group for analysis. The patients in the two groups received SNMS and PFMRT, and the patients in the observation group received home-based training additionally. The patients in the two groups were followed up for 6 months. The therapeutic effect, the pelvic floor muscle (PFM) strength, the situations of PFM tenderness and evaluation by Glazer surface electromyographic evaluation of pelvic floor, and the adverse reactions of the patients were compared between the groups. Results: The score (3.05±0.69 points) of the clinical global impression of improvement (CGI-I) of the patients in the observation group after treatment was significantly higher than that (2.12±0.57 points) of the patients in the control group. The PFM strength of the patients in the two groups after treatment had increased significantly. The grade by Laycock modified Oxford muscle strength classification (MOS) of the patients in the observation group was significantly better than that of the patients in the control group. The visual analogue scale (VAS) score of the patients in the two groups after treatment had decreased significantly, and which (2.84±1.06 points) of the patients in the observation group was significantly lower than that (3.65±1.44 points) of the patients in the control group. The values of the rapid contraction relaxation time, the average pre-resting electromyography and the average post-resting electromyography of the patients in the two groups after treatment had decreased significantly, and which (3.24±1.06 s, 4.83±1.45μV and 4.15±0.81μV) of the patients in the observation group were significantly lower than those (4.01±1.12 s, 5.66±1.61μV and 4.81±0.95μV) of the patients in the control group (all P<0.05). There was no any patient with obvious adverse reactions in the two groups during treatment. During the follow-up period, there was no significant difference in the CPP recurrence rate (1 case, 2.0% vs. 4 cases, 10.0%) of the patients between the two groups (Fisher's exact probability=0.167). Conclusion: Home-based training combined with SNMS and PFMRT for treating the patients with CPP has good effectiveness, which can improve their pelvic floor muscle strength and surface electromyography result, and can relieve their pain, and with the higher safety.
2024 Vol. 32 (6): 1370- [Abstract]（
56
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ZHANG Xingyue, REN Chunling, YANG Yufen, LV Wenjing
To explore the impacts of the concept of accelerated rehabilitation surgery (CARS) combined with the refined management for patients with ovarian cancer on their physiological stress during the radical ovarian cancer surgery and the postoperative complications. Methods: 100 patients with ovarian cancer who wanted radical ovarian cancer surgery were selected and were randomly assigned into two groups. The patients in the control group received the routine nursing intervention, while the patients in the study group received CARS combined with the refined management. The physiological stress and the incidence of complications during surgery of the patients were compared between the two groups. Results: There were no significant differences in the operation time and the intraoperative blood loss of the patients between the two groups (P>0.05). The values of the heart rate (72.8±5.7 beats /min), diastolic blood pressure (65.7±7.2 mmHg) and systolic blood pressure (114.6±8.7 mmHg) of the patients in the study group at 5 minutes after anesthesia were significantly lower than those (84.8±6.6 beats /min, 81.1±8.8 mmHg and 140.1±12.9 mmHg) of the patients in the control group. The incidence of the postoperative complications (6.0%) of the patients in the study group was significantly lower than that (20.0%) of the patients in the control group (all P<0.05). Conclusion: CARS combined with the refined management for nursing intervation of the patients with ovarian cancer can effectively alleviate their intraoperative physiological stress and reduce their postoperative complications incidence.
2024 Vol. 32 (6): 1375- [Abstract]（
64
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LI Xiaojuan1, LUO Xi2, ZHANG Lingli3
To investigate the impacts of Jiawei Erxian decoction combined with letrozole for ovulation induction of patients with polycystic ovary syndrome (PCOS) on their levels of serum anti Mullerian hormone (AMH) and sex hormones. Methods: 86 patients with PCOS diagnosed in hospital were selected and were randomly divided into two groups (43 cases in each group) by random number table method from March 2020 to August 2023. The patients in the control group were treated with letrozole for ovulation induction, while the patients in the study group were treated with Jiawei Erxian decoction combined with letrozole for ovulation induction. The ovulation induction status before and after treatment, such as the number of mature follicles, cervical mucus score and endometrial thickness during ovulation, the levels of sex hormones, such as estrogen (E2), follicle stimulating hormone (FSH), testosterone (T) and luteinizing hormone (LH), the AMH level and the adverse reactions rate of the patients in the two groups were statistically analyzed. Results: The number of mature follicles (5.3±0.6 follicles), the cervical mucus score (11.9±1.4 points), the endometrial thickness during ovulation (9.2±1.1 mm) and the pregnancy rate (74.4%) of the patients in the study group were significantly higher than those (3.8±0.5 follicles, 9.2±1.1 points, 6.5±0.9 mm and 46.5%) of the patients in the control group. The levels of the serum E2, T, LH and AMH of the patients in the two groups had decreased significantly and the FSH levels of the patients in the two groups had increased significantly, and the changes of which of the patients in the study group were significantly greater than those of the patients in the control group (all P<0.05). There was no difference in the incidence of the adverse reactions (16.3% vs. 9.3%) of the patients between the two groups (P>0.05). Conclusion: Jiawei Erxian decoction combined with letrozole for treating the patients with PCOS can significantly improve their ovulation situation and sex hormones levels, decrease their AMH level and increase their pregnancy rate after treatment.
2024 Vol. 32 (6): 1379- [Abstract]（
70
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MA Xiangai, WU Xiaoyan, HU Xin, WU Jie
To explore the effects of internet combined with “operation e waiting room” for patients with laparoscopic total hysterectomy on their preoperative visit awareness and anxiety level. Methods: A total of 102 patients who wanted laparoscopic total hysterectomy in hospital were selected and randomly divided into control group and experimental group (51 cases in each group) from January 2022 to October 2023. The patients in the control group were given routine perioperative nursing mode intervention and the patients in the experimental group were given internet combined with “operation e waiting room” nursing mode intervention. The awareness of the preoperative visits, the anxiety at different time points, the psychology and blood pressure changes and the nursing satisfaction of the patients， and the anxiety of the family members at different time points were compared between the two groups. Results: The preoperative visit awareness of the patients in the experimental group was significantly better than that of the patients in the control group. The nursing satisfaction (92.2%) of the patients in the experimental group was significantly better than that (76.5%) of the patients in the control group. The values of heart rate (76.48±9.23) and blood pressure (114.39± 6.54mmHg /76.07± 7.13mmHg) of the patients in the experimental group waiting in the operating room were significantly lower than those (83.51±8.19 and 123.58± 8.42mmHg /84.54± 6.49mmHg) of the patients in the control group. The scores of 7 items of the generalized anxiety disorder (GAD-7) scale of the patients in the experimental group at waiting in the operating room and in 1 day after surgery (7.19±2.58 points and 3.15±1.02 points) were significantly lower than those (9.35±3.26 points and 4.21±1.07 points) of the patients in the control group. The GAD-7 score (6.28±2.26 points) of the family members in the experimental group at waiting in the operating room was significantly lower than that (8.39±2.11 points) of the family members in the control group (all P<0.05). Conclusion: The application of internet combined with “operation e waiting room” for the patients with laparoscopic total hysterectomy can improve their awareness of preoperative visits, relieve their anxiety, help maintain stable their heart rate and blood pressure and improve their care satisfaction.
2024 Vol. 32 (6): 1383- [Abstract]（
63
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ZU Xiaoxia, CHEN Xiaojing, SHEN Huijun, ZHANG Minghua
To study the effect of vitamin D standard supplementation for preventing the metabolic diseases during pregnancy of pregnant women with vitamin D deficient. Methods: The clinical data of 422 puerperas admitted to hospital from January to September 2022 were analyzed retrospectively. The serum 25 hydroxyvitamin D level of the puerperas during 16 getational weeks was tested for diagniosing their vitamin D deficiency. According to the postpartum questionnaire on the puerperas whether regularly supplemented vitamin D or not during pregnancy, these puerperas were divided into the control group and the observation group (211 cases in each group). These puerperas in the two groups were given routine obstetric intervention, nutritional guidance, the regular antenatal examination until to delivery and the detection of the serum 25 hydroxyvitamin D of the puerperas during 32 gestational weeks. The incidence of the metabolic diseases during pregnancy, the vitamin D deficiency during the third trimester of pregnancy, the maternal delivery mode, the adverse delivery outcomes, the neonatal adverse outcomes, the neonatal Apgar score, and the satisfaction of the puerperas in the two groups were observed. Results: The incidence of metabolic diseases of the puerperas in the observation group during pregnancy was significantly lower than that of the puerperas in the control group. The incidence of vitamin D deficiency during the third trimester of pregnancy (1.0%), the rate of uterine delivery (10.0%), the adverse maternal outcomes (2.4%) and the adverse newborns outcomes (1.4%) of the puerperas were significantly lower than those (4.3%, 19.5%, 7.6% and 6.6%) of the puerperas in the control group. The satisfaction rate (97.6%) of the puerperas in the observation group was significantly higher than that (92.9%) of the puerperas in the control group (all P<0.05). Conclusion: The vitamin D standard supplementation during pregnancy of the pregnant women with vitamin D deficient can decrease their metabolic diseases occurrence, thereby which can improve the maternal and neonatal outcomes, and is more recognized by the women.
2024 Vol. 32 (6): 1389- [Abstract]（
65
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WANG Yue, WANG Xinyan, LIU Xinyue, LIU Chunwen, REN Yanhua, XU Wenbo
To investigate the value of body mass index (BMI) combined with the plasma fibrinogen (FIB) level of pregnant women with preeclampsia (PE) at delivery for assessing their postpartum deep vein thromboembolism (DVT). Methods: The clinical data of 70 pregnant women with PE from March 2021 to September 2022 were collected retrospectively. These women were divided into group A (16 women with DVT) and group B (54 without DVT) according to the presence or absence of postpartum DVT of the women. The clinical characteristics of the women were compared between the two groups. The risk factors of the postpartum DVT and the value of the BMI value combined with the plasma FIB level at delivery for predicting the postpartum DVT of the pregnant women with PE were analyzed. Results: The proportions of the pregnancy thrombosis history, the bed rest time during puerperium ≥72h and the BMI ≥30kg/m2 of the women in group A were significantly higher than those of the women in group B, and the FIB level (5.3±0.7 g/L) of the women in group A was significantly higher than that (4.6±0.6 g/L) of the women in group B (all P<0.05). The history of thrombosis, the bed rest time during puerperium >72h, the BMI≥30kg/m2, and the increased plasma FIB level of the women with PE were the independent risk factors of their postpartum DVT occurrence (P<0.05). The area under the ROC curve of the BMI≥30kg/m2, the plasma FIB level, and the combination of the BMI ≥30kg/m2 and the plasma FIB level of the women with PE at delivery for predicting postpartum DVT were 0.654, 0.744 and 0.836, respectively, and which of the combination of the BMI≥30kg/m2 and the plasma FIB level of the women at delivery was significantly higher than that of the BMI≥30kg/m2 or the plasma FIB level alone. Conclusion: The BMI≥30kg/m2 at delivery and the high plasma FIB level of the pregnant women with PE are the risk factors of their postpartum DVT occurrence, therefore, the combination of the BMI≥30kg/m2 and the plasma FIB level of the women at delivery has certain predictive value for their postpartum DVT occurrence.
2024 Vol. 32 (6): 1393- [Abstract]（
67
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ZHANG Qingqing, WEN Ming, CHEN Qi
To investigate the coreelation of the levels of gamma glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) and uric acid (UA) of pregnant women with hypertension disorders of pregnancy (HDP) and their disease severity and pregnancy outcomes. Methods: 72 pregnant women with HDP admitted to hospital were selected in study group from July 2022 to July 2023. These women were divided into group A (20 women with HDP only), group B (23 women with mild preeclampsia) and group C (21 women with severe preeclampsia). There were 38 women with normal pregnancy outcomes in group D and 26 women with adverse pregnancy outcomes in group E. 118 healthy pregnant women who had been antenatal examination were selected in control group during the same period. The clinical data, the levels of GGT, LDH and UA of the women were compared among these groups. The correlation of the levels of GGT, LDH and UA of the women with HDP and their disease severity was analyzed. The influence of the levels of GGT, LDH and UA of the women with HDP on their pregnancy outcomes was also analyzed. Results: The blood pressure value, and the serum GGT, LDH and UA levels of the women in the control group, in group A, in group B, and in group C had increased gradually. Spearman analysis showed that the HDP severity of the women was positively correlated with their serum GGT, LDH, and UA levels (all P< 0.05). The serum GGT, LDH and UA levels of the women in group E were significantly higher than those of the women in group D (P<0.05). Logistic regression analysis showed that the high expressions of the serum GGT, LDH, and UA of the women with HDP were the risk factors leading to the adverse pregnancy outcomes of the women (all P<0.05). Conclusion: The GGT, LDH and UA levels of the women with HDP are positively correlated with their severity of HDP, and the high level expressions of which are the risk factors of the adverse pregnancy outcomes of the women, so the GGT, LDH and UA levels of the women with HDP can provide the references for the clinical treatment and the prognosis evaluation of the women.
2024 Vol. 32 (6): 1397- [Abstract]（
53
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ZHANG Lei, ZHOU Lina, SUN Xiaona, YU Chunyan, BAI Yaqin
To investigate the correlation between the thromboelastography parameters and the calcium ion concentration (Ca2+) level of pregnant women with hypertension disorders of pregnancy (HDP) and their adverse pregnancy outcomes. Methods: A retrospective study was conducted on the clinical data of 130 pregnant women with HDP (in study group) and 125 normal pregnant women (in control group) from January to October 2022. The women in the study group were divided into group A (31 cases with severe preeclampsia), group B (49 cases with mild preeclampsia) and group C (50 cases with gestational hypertension only). According to the pregnancy outcomes, the women in the study group were divided into group D (39 cases with the adverse pregnancy outcomes) and group E (91 cases with the normal pregnancy outcomes). The values of thromboelastography parameters, such as reaction time (R), clot formation time (K), maximum amplitude (MA) and coagulation index (CI), and the Ca2+ level of the women were compared among these groups. The correlation between the thromboelastography parameters values and the Ca2+ level of the women with HDP and their adverse pregnancy outcomes was analyzed by logistic regression analysis. Results: The values of MA (72.40±8.55mm) and CI (3.75±1.01) of the women in the study group were significantly higher than those (60.33±7.28mm and 2.45±0.62) of the women in the control group. The values of R (3.21±0.54 min) and K (1.65±0.75 min), and the Ca2+ level (2.05±0.21 mmol/L) of the women in the study group were significantly lower than those (4.54±0.63 min, 1.82±0.43 min and 2.41±0.63 mmol/L) of the women in the control group. The values of MA and CI of the women in group C, in group B and in group A had increased gradually, but the values of R and K, and the Ca2+ level of the women in group C, in group B and in group A had decreased gradually. There were significant differences in the values of R, MA and CI, and the Ca2+ level of the women between group D and group E (all P< 0.05), but there was no significant difference in the K value of the women between group D and group E (P>0.05). Logistic regression analysis showed that the values of R, MA and CI, and the Ca2+ level of the women with HDP were all related to their adverse pregnancy outcomes (P<0.05). Conclusion: The thromboelastography parameters values and the Ca2+ level of the pregnant women with HDP are abnormal, and the changes of which have increased with the severity of HDP and are related to the adverse pregnancy outcomes of the women. It is suggested that the values of R, MA and CI, and the Ca2+ level and other indicators can be used to provide the reference for the targeted prevention and treatment of HDP of the pregnant women.
2024 Vol. 32 (6): 1402- [Abstract]（
77
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MA Qian1, LI Xiaoqing2, GU Lili1
To explore the correlation between the types of human papillomavirus (HPV) infection of pregnant women and their neonatal HPV infection. Methods: The clinical data of 100 pregnant women diagnosed with HPV infection during antenatal examination from January 2020 to October 2023 were selected in this study. The proportion of the different types of HPV infection of these women was calculated, and the incidence of the neonatal HPV infection and the proportion of the different types of the neonatal HPV infection were counted. These women were divided into group A (women with the high-risk HPV infection) and group B (women with the low-risk HPV infection) according to the HPV typing test results of the women. The differences of the immune function indexes values and the neonatal outcomes of the women were compared between the two groups. Results: Among 100 pregnant women with HPV infection, there were 75.0% women with high-risk HPV infection and 25.0% women with low-risk HPV infection. The HPV infection rate of the neonates was 40.0%, which included 77.5% neonates with high-risk HPV infection and 22.5% neonates with low-risk HPV infection. The levels of CD3+ (44.21±3.45%) and CD4+ (30.44±3.14%) of the women in group A were significantly lower than those (56.44±4.12% and 42.84±3.45%) of the women in group B. The rates of preterm birth (28.0%), premature rupture of membranes (21.3%), fetal growth restriction (30.7%) and neonatal HPV infection rate (46.7%) of the women in group A were all significantly higher than those (8.0%, 4.0%, 8.0% and 20.0%) of the women in group B (all P<0.05). Conclusion: The high-risk types of HPV infection, such as HPV16, HPV18 and HPV52, are the main HPV infection types of the pregnant women. The neonatal HPV infection of the pregnant women is consistent with their mothers. The pregnant women with high-risk HPV infection may increase their risk of the adverse neonatal outcomes because of their immune imbalance.
2024 Vol. 32 (6): 1406- [Abstract]（
70
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ZHANG Xiaoxu, XU Yeqing
To explore the correlation of triacylglycerol glucose (TyG) index of pregnant women with hypertension disorders of pregnancy (HDP) and their adverse pregnancy outcomes, and to study its predictive significance. Methods: A total of 102 pregnant women with diagnosed HDP were selected in study group from December 2020 to December 2023, and 100 normal pregnant women who came to hospital for pregnancy examination were selected in control group during the same period. The women in the study group were divided into group A (34 women with adverse pregnancy outcomes) and group B (68 women with normal pregnancy outcomes). The levels of fasting blood glucose (FPG) and triglyceride (TG) were measured by biochemical analyzer, and the TyG index was calculated. Receiver operator characteristic (ROC) curve was used to evaluate the value of the levels of TG and FPG, and TyG index of the women with HDP for predicting their adverse pregnancy outcomes. Multivariate logistic regression analysis was used to investigate the influencing factors of the adverse pregnancy outcomes of the women with HDP. Results: The levels of TG (1.67±0.51 mmol/L) and FPG (4.93±0.47 mmol/L), and the value of TyG index (8.75±0.36) of the women in the study group were significantly higher than those (1.51±0.43 mmol/L, 4.79±0.42) mmol/L and 8.56±0.36) of the women in the control group, and which of the women in group B were significantly higher than those of the women in group A (all P<0.05). The areas under the curve of the TG level, the FPG level and the TyG index value of the women with HDP for predicting their adverse pregnancy outcomes were 0.734, 0.821 and 0.915, respectively. Multivariate logistic stepwise regression analysis showed that the family history of hypertension, the TG level≥1.79mmol/L, the FPG level ≥5.11mmol/L, and the TyG index value ≥8.81 were the risk factors of their adverse pregnancy outcomes (all P<0.05). Conclusion: The TyG index value of the pregnant women with HDP is abnormally high expressed, which can be used to predict the adverse pregnancy outcomes of these women.
2024 Vol. 32 (6): 1410- [Abstract]（
93
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ZHAO Zhao, YOU Xiangju, YANG Handi
To analyze the correlation among the decision making behavior of blood glucose management, the blood glucose control, and the neonatal blood glucose level of pregnant women with gestational diabetes mellitus (GDM). Methods: The decision making behavior of blood glucose management of 103 pregnant women with GDM was investigated from August 2022 to August 2023, and according to the investigation results, these women were divided into group A(37 women with good behavior of blood glucose management) and group B (66 women with poor behavior blood glucose management). The clinical data of the women in the two groups were collected. The blood glucose control situation and the neonatal blood glucose level of the women in the two groups were recorded. Pearson correlation was used to analyze the correlation among the decision making behavior of blood glucose management, the blood glucose control, and the neonatal blood glucose level of pregnant women with GDM. Results: The levels of fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG) and glycosylated hemoglobin (HbAlc) of the women in group B were significantly higher than those of the women in group A. The neonatal FPG and 2hPG levels at 12 and 24 hours after birth in group B were significantly lower than those in group A (all P<0.05). The decision-making behavior of blood glucose management of the women with GDM was negatively correlated with the levels of their FPG, 2 hPG and HbAlc, and was positively correlated with the levels of their neonatal FPG and 2 hPG at 12h and 24h after birth. The levels of FPG, 2hPG and HbAlc of the women with GDM were negatively correlated with their neonatal FPG and 2 hPG at 12h and 24h after birth (all P<0.05). Multivariate logistic regression analysis showed that the low education level and the natural pregnancy of the women with GDM were the influencing factors of their decision-making behavior of blood glucose management (P<0.05). Conclusion: The decision-making behavior of blood glucose management, the maternal blood glucose level and the neonatal blood glucose level of the pregnant women with GDM are closely related. The influencing factors of the decision-making behavior of blood glucose management of the pregnant women with GDM should be paid attention to in clinic, and the publicity and the intervention on the decision-making behavior of blood glucose management of the women should be strengthen.
2024 Vol. 32 (6): 1415- [Abstract]（
70
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ZHUO Ya, ZHU Bin, WU Hongjie
To explore the correlation between the levels of serum interferon gamma induced protein 10 (IP10) and sulfhydryloxidase 1 (QSOX1) of pregnant women with hepatitis B virus (HBV) infection and the maternal and infant outcomes. Methods: 86 pregnant women with HBV infection treated from March 2021 to March 2023 were selected in the study group retrospectively, and 76 normal pregnant women during the same period were selected in the control group. The levels of serum IP10 and QSOX1 detected and the maternal and infant outcomes of the women were recorded and were compared between the two groups. The influencing factors of the maternal and infant outcomes of the pregnant women with HBV infection were explored by multivariate logistic regression model. Receiver operator characteristic (ROC) curve was used to evaluate the diagnostic value of the serum IP10 and QSOX1 levels of the women for their maternal and infant outcomes. Results: The levels of serum IP 10 (68.52±10.46 pg/ml) and QSOX1 (75.62±11.50 ng/ml) of the women in the study group were significantly higher than those (30.22±6.66 pg/ml and 45.25±7.62 ng/ml) of the women in the control group. The incidence of the adverse maternal and infant outcomes (50.0%) of the women in the study group was significantly higher than that (17.1%) of the women in the control group (all P<0.05). Multiple factors logistic stepwise regression analysis showed that the serum IP10 level (OR=1.740, 95% CI 1.403-2.159), the serum QSOX1 level (OR=4.225, 95%CI 2.0508.708) of the women with HBV infection were the main factors affecting their adverse maternal and infant outcomes (P<0.05). ROC curve analysis showed that the area under curve (AUC) of the serum IP10 level, the QSOX1 level, or the combined levels of the IP10 and QSOX1 of the women with HBV infected for evaluating their adverse outcomes of pregnancy were 0.854, 0.867 or 0.925, respectively. Conclusion: The levels of serum IP10 and QSOX1 of the pregnant women with HBV infection increase and the changes of the levels of serum IP10 and QSOX1 were the adverse influence factors of the maternal and infant outcomes, and which can be used as the indicators to evaluating the adverse maternal and infant outcomes of the pregnant women with HBV infection.
2024 Vol. 32 (6): 1420- [Abstract]（
65
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LIU Shanshan, YAN Jing
To explore the clinical value of abdominal and transvaginal ultrasound for diagnosing the endometrial cancer and its myometrial invasion of women. Methods: From February 2021 to February 2023, 80 women with endometrial cancer and 80 healthy women who had accepted physical examination were selected as the research objects. The abdominal ultrasound and transvaginal ultrasound were performed on all of these women. The results of the pathological examination of the women with endometrial cancer were used as the gold standard. The effect of single and combined application of abdominal ultrasound and transvaginal ultrasound for diagnosing the endometrial cancer and its myometrial invasion degree was compared and analyzed. The observation indicators in this study included the accuracy, the sensitivity, the specificity and the area under the receiver operating characteristic (ROC) curve. Results: The accuracy of the transvaginal ultrasound alone, the abdominal ultrasound alone, and the combined the transvaginal and abdominal ultrasound for diagnosing the endometrial cancer were 75.6%, 88.8% and 98.1%, respectively, the sensitivity of which were 75.0%, 87.5% and 97.5%, respectively, the specificity of which were 76.3%, 90.0% and 98.8%, respectively, and the AUC of which were 0.756, 0.888 and 0.981, respectively. The accuracy, the sensitivity, the specificity and the AUC of the transvaginal ultrasound alone, the abdominal ultrasound alone, and the combined the transvaginal and abdominal ultrasound for diagnosing the endometrial cancer had increased gradually. The accuracy of the transvaginal ultrasound alone, the ultrasound alone, and the combined the transvaginal and transabdominal ultrasound for diagnosing the myometrial invasion degree of the endometrial cancer were 62.5%, 82.5% and 97.5%, respectively, the sensitivity of which were 64.0%, 82.0% and 96.0%, respectively, and the specificity of which were 0.620, 0.827 and 0.980, respectively. The accuracy, the sensitivity and the specificity of the transvaginal ultrasound alone, the abdominal ultrasound alone, and the combined the transvaginal and abdominal ultrasound for diagnosing the myometrial invasion degree of the endometrial cancer had increased gradually (all P<0.05). Conclusion: Both abdominal ultrasound and transvaginal ultrasound for diagnosing the endometrial cancer and its myometrial invasion degree of the women have high application efficiency. The diagnostic efficiency of the transvaginal ultrasound alone, the ultrasound alone, and the combined the transvaginal and abdominal ultrasound for diagnosing the endometrial cancer and its myometrial invasion of the women have increased gradually.
2024 Vol. 32 (6): 1424- [Abstract]（
58
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ZHONG Junmin, GUO Kaimin, HUANG Zhuohua
To explore the differential blood gas of the umbilical artery of the twin of pregnant women during the trial vaginal delivery, and to study its correlative factors. Methods: A retrospective analysis was conducted on the clinical data of 36 pregnant women with twin pregnancies who had been trial vaginal delivery from December 2021 to January 2024. The clinical characteristics, the umbilical artery blood gas results and the neonatal outcomes of the women were analyzed, and the relevant factors of the differences of the umbilical artery blood gas indicators between the two fetuses were explored. Results: The results of umbilical artery blood gas analysis indicated that the values of pH (7.22±0.10) and alkaline residue (4.48±3.29 mmol/L) of umbilical artery blood gas of the second fetus were significantly lower than those (7.29±0.06 and 3.10±3.27 mmol/L) of the first fetus, but the lactate level (3.68±1.52 mmol/L) of umbilical artery blood of the second fetus was significantly higher than that (3.00±1.15 mmol/L) of the first fetus. The differences of the blood gas indexes of the two fetuses had no correlation with the maternal age, the fetal position before delivery, the chorionic nature, the gestational weeks at delivery, the mode of initiation of labor, the mode of induction, the oxytocin used and the fetal heart rate monitoring during labor, the delivery outcomes, the fetal position at delivery, the whether the neonates transferred to hospital, but which had moderately correlation with the primiparas rate and the BMI of the women, and the neonatal Apgar score at 1min and 5min after birth. Conclusion: This study suggests that during the trial vaginal delivery of the pregnant women with twins, the second fetus of the women has the relatively poor umbilical artery blood gas status, which indicating that the second fetus has the increased risk of acute hypoxia during labor. However, the pregnant women with twins are given standardized labor management, which do not increase their adverse neonatal outcomes in clinical practice.
2024 Vol. 32 (6): 1429- [Abstract]（
58
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WU Dan, WANG Luya, HE Lilin
To study the effect of magnetic stimulation combined with kegel pelvic floor muscle function training for treating patients with postpartum mild uterine prolapsed. Methods: The clinical data of 102 patients with postpartum mild uterine prolapse who delivered in hospital from January 2022 to September 2023 were collected. These patients were given routine health education, and among them, 48 patients with same symptoms who received routine health education combined had received kegel pelvic floor muscle function training for 3 months in control group and 49 patients had received magnetic stimulation therapy combined with kegel pelvic floor muscle function training for 3 months in treatment group. The situation of the involution of uterus, the pelvic floor muscle strength grade, the urinary leakage times and the nocturia frequency of the patients were compared between the two groups. Results: After 3 months of intervention, the uterine volume, the sum of the three uterine diameters and the height of the uterine fundus of the patients in the two groups had decreased significantly, and which (136.72±5.69 cm3, 15.72±2.46 cm and 5.71±1.03 cm) of the patients in the treatment group were significantly lower than those (139.48±4.34 cm3, 17.41±2.36 cm and 6.62±0.94 cm) of the patients in the control group. The pelvic floor muscle strength grade of the patients in the two groups had increased significantly, and which of the patients in the treatment group was significantly higher than that of the patients in the control group. The urinary leakage times and the nocturia frequency of the patients in the two groups had decreased significantly, and which of the patients (2.07±0.41 times/d and 1.12±0.32 times/d) of the patients in the treatment group were significantly lower than those (2.62±0.52 times/d and 1.71±0.47 times/d) of the patients in the control group (all P<0.05). Conclusion: Magnetic stimulation combined with kegel pelvic floor muscle function training for treating the patients with postpartum mild uterine prolapsed has better effect, and which
can promote their involution of uterus and improve their pelvic floor muscle strength and pelvic floor function.
2024 Vol. 32 (6): 1434- [Abstract]（
66
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CHEN Liyuan, REN Yongfeng, LIU Xiaoyan, QI Jianguo, LI Jian, WANG Zhou
To study the diagnostic value of ultrasound shear wave elastography (SWE) combined with conventional four-dimensional pelvic floor ultrasound for the pelvic floor dysfunction of patients. Methods: The clinical data of 80 patients who had undergone the pelvic floor ultrasound examination from December 2020 to December 2023 were collected. All the patients were given conventional four-dimensional pelvic floor ultrasound examination and SWE examination. The occurrence of the pelvic floor dysfunction of these patients was counted. According to whether the pelvic floor dysfunction occurred or not, these patients were divided into group A (patients with pelvic floor dysfunction) and group B (patients without pelvic floor dysfunction). The values of the conventional fourdimensional pelvic floor ultrasound and SWE indicators of the patients were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the application value of SWE combined with the conventional four-dimensional pelvic floor ultrasound for diagnosing the pelvic floor dysfunction of the patients. Results: There were 19 of 80 patients with pelvic floor dysfunction, with a total incidence of 23.8%. The cervix orifice distance (COD) (9.85±2.05 mm) and the bladder neck descent (BND) (22.68±4.01 mm) under the maximum Valsalva state of the patients in group A were significantly greater than those (5.91±1.62 mm and 19.75±3.99 mm) of the patients in group B (P<0.05). The Young’s modulus value of right puborectalis (PR) of the patients (35.74±5.32 kPa) under the resting state of the patients in group A was significantly higher than that (19.91±3.07 kPa) of the patients in group B, and the Young’s modulus value of right PR (36.10±4.36 kPa) of the patients in group A under the maximum Valsalva state was significantly lower than that (39.92±4.51 kPa) of the patients in group B (all P<0.05). The area under the curve, the sensitivity and the specificity of the combined detections of the values COD, BND, the right PR Young’s modulus under the resting state and the right PR Young’s modulus under the maximum Valsalva state of the patients for diagnosing their pelvic floor dysfunction were 0.986, 94.7% and 73.8%, respectively, and which were significantly higher than those of the single detection (P<0.05). Conclusion: SWE combined with conventional four-dimensional pelvic floor ultrasound for diagnosing the pelvic floor dysfunction of the female patients has high application value, which can provide reference for the early clinical diagnosis of pelvic floor dysfunction of the patients.
2024 Vol. 32 (6): 1439- [Abstract]（
92
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HUANG Xue1, ZHOU Jingjing1, LI Mengni1, BAI Wei2, RONG Yajuan1, SHAO Yue1
To explore the diagnostic value of the pelvic floor ultrasound and Green classification for the postpartum early pelvic floor structure and stress urinary incontinence (SUI) of puerperae. Methods: A total of 204 puerperae were enrolled in this study between March 2021 and March 2023. According to the occurrence of the postpartum early SUI, these puerperae were divided into group A (82 cases with SUI) and group B (122 cases without SUI). The values of bladder neck-symphyseal distance (BSD), posterior urethrovesical angle (PUA), bladder neck descent (BND) and urethral rotation angle (UR) under rest and Valsalva manoeuvre states of the puerperae were detected and were compared between the pelvic floor ultrasound and Green classification. The diagnostic value of the relevant parameters of the pelvic floor ultrasound and Green classification for the SUI of the puerperae was analyzed by receiver operator characteristic (ROC) curves. Results: Under rest state, there was no significant difference in the pelvic floor ultrasound parameters of the puerperae between the two groups (P>0.05). Under Valsalva manoeuvre state, the values of BSD, PUA, BND and UR of the puerperae in group A were significantly higher than those of the puerperae in group B, and the proportion of the type Ι of Green classification (25.6%) of the puerperae in group A was significantly lower than that (59.8%) of the puerperae in group B (all P<0.05). The results of ROC curves analysis showed that the diagnostic value of Green classification (AUC=0.579) was poor for SUI of the puerperae (P=0.057). Under Valsalva manoeuvre state, the AUC of the BSD value, PUA value, BND value and UR value of Green classification of the puerperae for their SUI occurrence were 0.758, 0.743, 0.769 and 0.705, respectively, and which had good diagnostic value for SUI (P<0.05). Conclusion: The pelvic floor ultrasound and Green classification of the puerperae can effectively evaluate the postpartum early pelvic floor structure, and the pelvic floor ultrasound can diagnose the SUI occurrence of the puerperae.
2024 Vol. 32 (6): 1444- [Abstract]（
81
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JIN Yun, GE Hangqi, ZHENG Xin, LI Tingting
To investigate the influencing factors of shivering during cesarean section of puerperaes. Methods: 360 puerperaes who had undergone cesarean section admitted to the obstetrics department of the hospital from January 2021 to December 2023 were collected retrospectively. These puerperaes were divided into group A (puerperaes with shivering during cesarean section) and group B (puerperaes without shivering during cesarean section) according to the score of bedside shivering assessment scale (BSAS). The univariate analysis and multi-factor logistic analysis were used to analyze the risk factors of the shivering situation of the puerperaes during cesarean section. Results: There were 87 (24.2%) puerperaes with intraoperative shivering occurred in the 360 puerperaes. There were significant differences in the age, the body mass index (BMI) before delivery, the fasting time, the rate of multipara, the rate of emergency admission, the anesthesia method, the time from entering the operative room to successful anesthesia, the operation time, the blood loss, the intraoperative infusion quantity, the infusion temperature, the rate of warming blanket used, the rate of dexmedetomidine/esketamine used, the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS), and the rates of obstetric emergencies and fetal distress/neonatal asphyxia of the puerperaes between the two groups (P<0.05). Multivariate logistic analysis showed that the advanced age, the long fasting time, the emergency admission, the spinal anesthesia, the long time from entering the operative room to successful anesthesia, the long operation time, the more blood loss, the more intraoperative infusion volume, the low temperature of infusion fluid, the high scores of SAS and SDS, the obstetric emergency and the fetal distress/neonatal asphyxia of the puerperaes were all the risk factors of their shivering occurrence. The BMI value before delivery, the multiparas, the warming blanket used and dexmedetomidine/esmketamine used of the puerperaes were all the protective factors of their shivering occurrence (all P<0.05). Conclusion: The incidence of shivering of the puerperaes during cesarean section is higher, and the influencing factors of which are many. The active prevention and treatment targeting these influencing factors should be taken for reducing the incidence of their shivering and improve their operative safety.
2024 Vol. 32 (6): 1448- [Abstract]（
63
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JI Kai, ZHU Yan
To analyze the distribution of 5, 10-methylenetetrahydro folic acidreductase (MTHFR) C677T locus polymorphism of women of childbearing age, and to study its correlation with the adverse pregnancy outcomes of the women in Changji of Xinjiang. Methods: 642 women of childbearing age were collected in control group from May 2023 to February 2024. Another 285 women with pregnant history (in study group) were selected in study group, including 146 cases with adverse pregnant history in group A and 139 cases without adverse pregnant history in group B. The blood samples of the women in the control group and the study group were collected, and the polymorphism of MTHFR gene C677T locus of these women was detected by fluorescence quantitative polymerase chain reaction. The characteristics of the gene polymorphism of the women in these groups were analyzed. Results: The genotype frequencies of CC, CT and TT of MTHFR C677T locus of 642 women of childbearing age were 26.0%, 51.3% and 22.7%, respectively, which were significantly different from those of the women in the southern and northern cities of China (P<0.05). In this study, there was no significant differences in the gene types and the frequency of alleles among the women with different age (P>0.05). The proportions of the normal non-risk genotype (CC genotype) of the women in group A and group B were 22.6% and 27.3%, the proportions of the moderate risk genotype (CT genotype) of the women in group A and group B were 50.7% and 51.8%, and the proportions of the high risk genotype (TT genotype) of the women in group A and group B were 26.7% and 20.9%. There were significant differences in the proportions of the different genotype of the women between group A and group B (P<0.05). Conclusion: The distribution of MTHFR C677T genotype of the women of childbearing age has significantly regional different and the homozygous mutation (TT Type) of the women may be associated with their adverse pregnancy outcomes.
2024 Vol. 32 (6): 1453- [Abstract]（
62
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LI Yaya1,2,3, CHEN Yaoping2,3, XU Xian2,3
Male factors account for about 50% of global infertility, among which, the patients with azoospermia usually need to obtain the small amount of sperm through surgery, or the patients with very severe oligoasthenospermia have a small number of sperm, so it is difficult to find viable sperm after freezing resuscitation with conventional frozen carriers. Therefore, in order to avoid the cancellation of the cycle because of the unavailable sperm on the day of egg retrieval, the small number of sperm are clinically frozen by the microsperm freezing carriers in advance, such as empty egg zona, alginate capsules, micro-drop method, straws, pieces, glass denuding pipette, etc. In this paper, the research on the different cryopreservation carriers of the small quantity of the patients with spermatozoa was reviewed, so as to provide the theoretical basis for optimizing cryopreservation methods of the microsperm of the patients in clinic.
2024 Vol. 32 (6): 1457- [Abstract]（
61
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