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| Correlation between the thromboelastography parameters and the calcium ion concentration level of pregnant women with hypertension disorders of pregnancy and their adverse pregnancy outcomes |
| Shijiazhuang Maternal and Child Health Care Hospital, Shijiazhuang, Hebei Province, 050000 |
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Abstract To investigate the correlation between the thromboelastography parameters and the calcium ion concentration (Ca2+) level of pregnant women with hypertension disorders of pregnancy (HDP) and their adverse pregnancy outcomes. Methods: A retrospective study was conducted on the clinical data of 130 pregnant women with HDP (in study group) and 125 normal pregnant women (in control group) from January to October 2022. The women in the study group were divided into group A (31 cases with severe preeclampsia), group B (49 cases with mild preeclampsia) and group C (50 cases with gestational hypertension only). According to the pregnancy outcomes, the women in the study group were divided into group D (39 cases with the adverse pregnancy outcomes) and group E (91 cases with the normal pregnancy outcomes). The values of thromboelastography parameters, such as reaction time (R), clot formation time (K), maximum amplitude (MA) and coagulation index (CI), and the Ca2+ level of the women were compared among these groups. The correlation between the thromboelastography parameters values and the Ca2+ level of the women with HDP and their adverse pregnancy outcomes was analyzed by logistic regression analysis. Results: The values of MA (72.40±8.55mm) and CI (3.75±1.01) of the women in the study group were significantly higher than those (60.33±7.28mm and 2.45±0.62) of the women in the control group. The values of R (3.21±0.54 min) and K (1.65±0.75 min), and the Ca2+ level (2.05±0.21 mmol/L) of the women in the study group were significantly lower than those (4.54±0.63 min, 1.82±0.43 min and 2.41±0.63 mmol/L) of the women in the control group. The values of MA and CI of the women in group C, in group B and in group A had increased gradually, but the values of R and K, and the Ca2+ level of the women in group C, in group B and in group A had decreased gradually. There were significant differences in the values of R, MA and CI, and the Ca2+ level of the women between group D and group E (all P< 0.05), but there was no significant difference in the K value of the women between group D and group E (P>0.05). Logistic regression analysis showed that the values of R, MA and CI, and the Ca2+ level of the women with HDP were all related to their adverse pregnancy outcomes (P<0.05). Conclusion: The thromboelastography parameters values and the Ca2+ level of the pregnant women with HDP are abnormal, and the changes of which have increased with the severity of HDP and are related to the adverse pregnancy outcomes of the women. It is suggested that the values of R, MA and CI, and the Ca2+ level and other indicators can be used to provide the reference for the targeted prevention and treatment of HDP of the pregnant women.
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