To explore the effects of internet combined with “operation e waiting room” for patients with laparoscopic total hysterectomy on their preoperative visit awareness and anxiety level. Methods: A total of 102 patients who wanted laparoscopic total hysterectomy in hospital were selected and randomly divided into control group and experimental group (51 cases in each group) from January 2022 to October 2023. The patients in the control group were given routine perioperative nursing mode intervention and the patients in the experimental group were given internet combined with “operation e waiting room” nursing mode intervention. The awareness of the preoperative visits, the anxiety at different time points, the psychology and blood pressure changes and the nursing satisfaction of the patients， and the anxiety of the family members at different time points were compared between the two groups. Results: The preoperative visit awareness of the patients in the experimental group was significantly better than that of the patients in the control group. The nursing satisfaction (92.2%) of the patients in the experimental group was significantly better than that (76.5%) of the patients in the control group. The values of heart rate (76.48±9.23) and blood pressure (114.39± 6.54mmHg /76.07± 7.13mmHg) of the patients in the experimental group waiting in the operating room were significantly lower than those (83.51±8.19 and 123.58± 8.42mmHg /84.54± 6.49mmHg) of the patients in the control group. The scores of 7 items of the generalized anxiety disorder (GAD-7) scale of the patients in the experimental group at waiting in the operating room and in 1 day after surgery (7.19±2.58 points and 3.15±1.02 points) were significantly lower than those (9.35±3.26 points and 4.21±1.07 points) of the patients in the control group. The GAD-7 score (6.28±2.26 points) of the family members in the experimental group at waiting in the operating room was significantly lower than that (8.39±2.11 points) of the family members in the control group (all P<0.05). Conclusion: The application of internet combined with “operation e waiting room” for the patients with laparoscopic total hysterectomy can improve their awareness of preoperative visits, relieve their anxiety, help maintain stable their heart rate and blood pressure and improve their care satisfaction.