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| Coreelation of the levels of gamma glutamyl transpeptidase, lactate dehydrogenase and uric acid of pregnant women with hypertension disorders of pregnancy and their disease severity and adverse pregnancy outcomes |
| Wuhu First People's Hospital, Wuhu, Anhui Province, 241000 |
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Abstract To investigate the coreelation of the levels of gamma glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) and uric acid (UA) of pregnant women with hypertension disorders of pregnancy (HDP) and their disease severity and pregnancy outcomes. Methods: 72 pregnant women with HDP admitted to hospital were selected in study group from July 2022 to July 2023. These women were divided into group A (20 women with HDP only), group B (23 women with mild preeclampsia) and group C (21 women with severe preeclampsia). There were 38 women with normal pregnancy outcomes in group D and 26 women with adverse pregnancy outcomes in group E. 118 healthy pregnant women who had been antenatal examination were selected in control group during the same period. The clinical data, the levels of GGT, LDH and UA of the women were compared among these groups. The correlation of the levels of GGT, LDH and UA of the women with HDP and their disease severity was analyzed. The influence of the levels of GGT, LDH and UA of the women with HDP on their pregnancy outcomes was also analyzed. Results: The blood pressure value, and the serum GGT, LDH and UA levels of the women in the control group, in group A, in group B, and in group C had increased gradually. Spearman analysis showed that the HDP severity of the women was positively correlated with their serum GGT, LDH, and UA levels (all P< 0.05). The serum GGT, LDH and UA levels of the women in group E were significantly higher than those of the women in group D (P<0.05). Logistic regression analysis showed that the high expressions of the serum GGT, LDH, and UA of the women with HDP were the risk factors leading to the adverse pregnancy outcomes of the women (all P<0.05). Conclusion: The GGT, LDH and UA levels of the women with HDP are positively correlated with their severity of HDP, and the high level expressions of which are the risk factors of the adverse pregnancy outcomes of the women, so the GGT, LDH and UA levels of the women with HDP can provide the references for the clinical treatment and the prognosis evaluation of the women.
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