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| Significance of triglyceride glucose index of pregnant women with hypertension disorders of pregnancy for predicting their adverse pregnancy outcomes |
| Linping District Maternal and Child Health Care Hospital, Hangzhou, Zhejiang Province, 311222 |
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Abstract To explore the correlation of triacylglycerol glucose (TyG) index of pregnant women with hypertension disorders of pregnancy (HDP) and their adverse pregnancy outcomes, and to study its predictive significance. Methods: A total of 102 pregnant women with diagnosed HDP were selected in study group from December 2020 to December 2023, and 100 normal pregnant women who came to hospital for pregnancy examination were selected in control group during the same period. The women in the study group were divided into group A (34 women with adverse pregnancy outcomes) and group B (68 women with normal pregnancy outcomes). The levels of fasting blood glucose (FPG) and triglyceride (TG) were measured by biochemical analyzer, and the TyG index was calculated. Receiver operator characteristic (ROC) curve was used to evaluate the value of the levels of TG and FPG, and TyG index of the women with HDP for predicting their adverse pregnancy outcomes. Multivariate logistic regression analysis was used to investigate the influencing factors of the adverse pregnancy outcomes of the women with HDP. Results: The levels of TG (1.67±0.51 mmol/L) and FPG (4.93±0.47 mmol/L), and the value of TyG index (8.75±0.36) of the women in the study group were significantly higher than those (1.51±0.43 mmol/L, 4.79±0.42) mmol/L and 8.56±0.36) of the women in the control group, and which of the women in group B were significantly higher than those of the women in group A (all P<0.05). The areas under the curve of the TG level, the FPG level and the TyG index value of the women with HDP for predicting their adverse pregnancy outcomes were 0.734, 0.821 and 0.915, respectively. Multivariate logistic stepwise regression analysis showed that the family history of hypertension, the TG level≥1.79mmol/L, the FPG level ≥5.11mmol/L, and the TyG index value ≥8.81 were the risk factors of their adverse pregnancy outcomes (all P<0.05). Conclusion: The TyG index value of the pregnant women with HDP is abnormally high expressed, which can be used to predict the adverse pregnancy outcomes of these women.
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