Objective: To observe the expression of TLR4 in blastocyst and endometrium befor implantation and to explore its effect on the biological behavior of trophoblast cells. Methods: The expressions of TLR4 protein in mouse blastocyst and endometrium before implantation were shown with immunohistochemistry, and the attachment and outgrowth of blastocyst trophoblast cells were observed by anti-TLR4 antibody with co-culture implantation model of mouse blastocyst and human decidual cells. Results: TLR4 protein was positively expressed in the cytoplasm of the inner cell mass and trophoblast cells of mouse blastocyst. The ratio of attachmen was no significant difference between different concentration of TLR4 antibody group 78.52±2.47、82.3±2.6、77.3±3.0 and control group 87.4±2.3 (P>0.05).The ratio of outgrowth in 100ng/ml group 64.3±4.0 was lower than that of control group 83.5±3.3 (P< 0.05). The ratio of outgrowth in 200ng/ml group 51.3±4.1 and 400ng/ml group 46.2±4.2 was significantly lower than that of control group (P< 0.01). The spreading areas of different concentration groups 63.5±5.0、60.2±5.2、58.5±4.8 was significantly lower than that of control group 194.1±8.2 (P< 0.01), and its expanded area was inhibited in a dosedependent manner. Conclusion: TLR4 does not affect the attachment of blastocyst trophoblast cells, which may be related to the invasion and the further development of embryonic trophoblast cells.

2019 Vol. 27　(7):　839- [Abstract]（ 346 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To investigate the implementation of pre-pregnancy health examination intervention measures, and to explore the improvement measures. Methods: The field quantitative and qualitative research were carried out in people of child-bearing age, managers, and service providers from 25 counties of Yunnan province (cities and districts) in 2018, where pre-pregnancy health examination program and other public health programs had implemented. Results: In the included 171 people in childbearing age, 50.9% people had exposed to risk of birth defect, and the top three risk categories were nutritional lifestyle (33.3%), chronic disease (28.6%), and infectious disease (21.4%). 66.7% people who exposed to risk had implemented the pre-pregnancy health intervention measures. The availability of face-to-face counseling and guidance, knowledge, attitude and behavior, as well as the quality of service, skills, and service steps had affected the implementation of pre-pregnancy health intervention measures of the people. Conclusion: In order to provide the better supportive environment for people in child-bearing age with the best health status of pregnancy, the appropriate interventions or refer to other services stations should be suggested by providing information face to face, teaching skills, promoting the knowledge, improving the attitude and behavior of people, and optimizing the service quality and service steps.

2019 Vol. 27　(7):　848- [Abstract]（ 427 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To explore the clinical efficacy of Chinese herbs of invigorating spleen and eliminating phlegm combined with health guidance for treating women with polycystic ovary syndrome (PCOS) of obese phlegm-dampness type. Methods: 84 patients with PCOS of obese phlegm-dampness were divided into two groups by random number table method (42 cases in each group). The women in the control group were treated by routine western medicine combined with health guidance, while the women in the observation group were treated by spleen-strengthening and traditional Chinese medicine on phlegm-eliminating combined with health guidance. The clinical effects of the women in the two groups were compared. Results: After treatment, the levels of sex hormone, IGF-1, BMI and HOMA-IR of women in the both groups decreased significantly, and the those of women in the observation group were significant lower than those of women in the control group (P<0.05). The total effective rate (92.9%) of women in the observation group was significant higher than that (73.8%) of women in the control group (P<0.05). Conclusion: The traditional Chinese medicine on invigorating spleen and expelling phlegm combined with health guidance is used for treating women with PCOS can effectively reduce the levels of serum follicle stimulating hormone, luteinizing hormone, testosterone and other sex hormones, which also can alleviate clinical symptoms and signs, reduce BMI value, and has better therapeutic effect.

2019 Vol. 27　(7):　854- [Abstract]（ 312 ） HTML (0 KB)  PDF  (0 KB)  ( 46 )

Objective: To explore the curative efficacy of aspirin combined with polycystic ovary syndrome, and to study its influence on the levels of serum dehydroepiandrosterone sulfate (DHEAS), adropin protein (adropin) and monocyte chemoattractant protein-1 (MCP-1). Methods: 257 women with polycystic ovary syndrome were included and divided into the observation group (137 cases) and the control group (120 cases) by the random number table from January 2015 to January 2018. The women in the control group were treated by progesterone combined with clomiphene for 3 menstrual cycles, and the women in the observation group were treated by aspirin combined with clomiphene for 3 menstrual cycles. The effects and adverse reactions of women were compared between the two groups. Results: After treatment, the levels of serum DHEAS, MCP-1, follicular estrogen (FSH), and luteinizing hormone (LH) of women in the observation group were significant lower than those of women in the control group, but the level of adropin was significant higher than that of women in the control group (P<0.05), and the endometrium of women in follicular phase, ovulation phase, and luteal phase were significant thicker than those of women in the control group (P<0.05). Six months after treatment, the ovulation rate and pregnancy rate of women in the observation group were significant higher than those of women in the control group (P<0.05), but there was no significant difference in the incidence of adverse reaction between the two groups (P>0.05). Conclusion: Aspirin combined with progesterone for treating women with polycystic ovary syndrome can improve the efficacy, which can effectively regulate the serum DHEAS, adropin and MCP-1 expression of women, and can improve the thickness of endometrium and increase the pregnancy rate of women.

2019 Vol. 27　(7):　862- [Abstract]（ 352 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To evaluate the effect of dexmedetomidine combined with sufentanil used for patient controlled intravenous analgesia (PCA) during labor. Methods: 122 parturient women were selected and divided into the observation group and the control group according to different medication schemes (61 cases in each group) from March 2017 to December 2017.All women were treated by PCA, and sufentanil was given to the women in the control group, and sufentanil combined with dexmedetomidine was given to the women in the observation group. The dosage of sufentanil, the pressed times of PCA, hemodynamic changes, visual analogue score (VAS), Ramsay sedation score (RSS) and adverse reactions rates were compared between the two groups. Results: The dosage of sufentanil and the pressed times of PCA of women in the observation group were significant lower than those of women in the control group (P<0.05). There was no significant difference in the values of mean arterial pressure (MAP) and blood oxygen saturation (SpO2) of women between the two groups (P<0.05). The VAS at 6h, 12h or 24h after operation of women in the observation group was significant lower than that of women in the control group, and the RSS was significant higher than that of women in the control group (P<0.05). The total incidence rate of adverse reactions of women in the observation group was significant lower than that of women in the control group (P<0.05), and the total satisfaction degree of women in the observation group was significant higher than that of women in the control group (P<0.05). Conclusion: Dexmedetomidine combined with sufentanil used for PCA during labor can reduce the dosage of sufentanil significantly, improve the analgesic and sedative effect, and has fewer adverse reactions and higher satisfaction, so it can be applied to postpartum analgesia.

2019 Vol. 27　(7):　870- [Abstract]（ 334 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

Objective: To observe the influence of single balloon dilation induced labor on the delivery mode and perinatal complications of full term pregnant women. Methods: 249 full term pregnant women were selected as the research objects from March 2017 to June 2018, and all the women were divided into the study group (induced labor by single balloon dilation), the control group 1 (induced labor by double balloon dilation), and the control group 2 (induced labor by dinoprostone suppository) according to the random number table method. The delivery mode, labor, and cervical Bishop scores of before and after induction of women were recorded. The degree of cervical ripening, the weight of the newborn, the 1 min Apgar score, the medical expenses, and rate of perinatal complications of women were evaluated. Results: The Bishop scores of women in the study group (7.4±1.5 points) or the control group 1 (7.4±1.5points) was significant higher than that (6.2±1.3points) of women in the control group 2 (t=3.126, 3.089, P=0.000, 0.000). The total effective rate of promoting cervical maturation of women in the study group (92.8%) or the control group 1 (91.6%) was significant higher than that (78.3%) of women in the control group 2  (χ2=7.014, 5.698, P=0.008, 0.017). The vaginal delivery rate of women in the study group (83.1%) or in the control group 1 (84.3%) was significant higher than that (69.9%) of in the control group 2 (χ2=4.055, 4.914, P=0.044, 0.027). The time of the second stage of labor of women in the study group or in the control group 1 was significant longer than that of women in the control group 2 (t=3.976, 4.345, P=0.000, 0.000). The medical expenses of women in the study group was significant lower than that of women in the control group 1 or in the control group 2 (t=3.582, 6.714, P=0.000, 0.000). Conclusion: Single balloon dilatation can effectively improve the cervical maturity of full term pregnant women, increase the success rate of vaginal delivery, and reduce the cesarean section rate, and increase the incidence of perinatal complications. Single balloon dilatation has the same comprehensive efficacy and safety as double balloon dilatation when induced labor, but which has lower medical cost, so it is worthy of clinical application.

2019 Vol. 27　(7):　878- [Abstract]（ 310 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To evaluate the effect of volume therapy based on stroke volume variation(SVV) of patients in gynecologic laparoscopic surgery. Methods: 53 patients with gynecological tumors (ASA I-III, 18-65 years old) who had undergone gynecologic laparoscopic surgery were included and randomly divided into group A (fluid therapy based on SVV) and group B (conventional fluid therapy). The blood pressure (BP) and central venous pressure (CVP) of all patients were monitored through radial artery puncture and internal jugular vein puncture under local anesthesia. The Flotrac/Vigileo system was used to obtain SVV value and cardiac index (CI)．The patients in group A had received fluid therapy based on values of SVV, MAP, and CI, and CI≥2.6L/min/m2 and SVV 8-12 of patients were the treatment goal indexes. The patients in group B had received conventional fluid therapy based on"4-2-1" rule．The liquid flow in and out during surgery, crystalloid requirements, the changes of MAP, HR and CVP of all women at the onset of the monitoring (T1), the induction time after anesthesia (T2), the beginning of surgery (T3), 1 hour after surgery (T4) and the end of the surgery (T5) were recorded．The values of MAP, HR and the concentration of serum lactate of all women when transferred to ward and 24 hours after operation were also recorded. The incidence of postoperative complications and time of stay in hospital of patients in the two groups were observed. Results: The volume of colloid fluid used and values of CI and CVP at T3 and T4 of women in group A were significant higher than that of women in group B, but the volumes of crystal fluid used and urinary output, the concentration of serum lactate, and the incidence of adverse reaction of women in group A were significant lower (P<0.05)．Conclusion: The volume therapy based on SVV can optimize the cardiac preload of patients who undergoing gynecologic laparoscopic surgery, improve their cardiac output, guarantees their perfusion of microcirculation, reduce the incidence of adverse reactions, and shorten time of hospitalization, which is more effective than conventional fluid therapy．

2019 Vol. 27　(7):　886- [Abstract]（ 379 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore application value of pelvic floor muscle exercise during pregnancy combined with postpartum biofeedback electrical stimulation after delivery. Methods: From July 2016 to December 2017, 300 pregnant women were selected in this study, which included 182 women experienced vaginal delivery (group A1), 98 women experienced cesarean section (group B1), and all these 300 women received pelvic floor muscle exercise during pregnancy combined with postpartum biofeedback electrical stimulation after delivery. In addition, other 45 women after delivery were selected in control group (women in group A2 had experienced vaginal delivery, and women in group B2 had experienced cesarean section). The pelvic floor muscle strength, vaginal pressure, and vaginal contraction duration of women were compared among the four groups, and the incidence of pelvic floor dysfunction of women was also compared among the four groups. Results: At week 6 and 12 after delivery, the degree of pelvic floor type I and type II muscle strength, vaginal resting pressure, and vaginal systolic blood pressure, and the time of duration of guided vaginal contractions guided of women in group A1 were significant better than those of women in group A2 (P<0.05). The incidences of anterior and posterior vaginal prolapsed, and urinary incontinence of women in group A1 were significant lower than those of women in group A2 at postpartum 12 week (P<0.05). At postpartum 6 week, the pelvic floor muscle strength of women in group B1 was significant better than that of women in group B2b (P<0.05). At 12 weeks postpartum, the degree of pelvic floor type I and type II muscle strength, vaginal resting and systolic pressure, and the time of duration of vaginal contraction guided of women in the B1 group were significant superior to those of women in group B2, and the incidence of anterior vaginal wall prolapse and urinary incontinence of women were significant lower than those of women in group B2 (P<0.05). Conclusion: No matter the delivery mode of women, the pelvic floor muscle exercise during pregnancy combined with biofeedback electrical stimulation after delivery for women can effectively improve the pelvic floor muscle strength and pelvic floor function, and reduce the incidence of postpartum pelvic floor dysfunction.

2019 Vol. 27　(7):　894- [Abstract]（ 364 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore the cytogenetic etiological analysis of the villi of women with missed abortion, and to analyze its clinical significance. Methods: From January 2015 to March 2017, 98 women with missed abortion were selected into the study group, and another 98 normal pregnant women who voluntarily terminated pregnancy during the same period were selected into the control group. The villus tissues of women in the two groups were collected and the cells were isolated from these villus tissue for cultured. G-banding technique was used to analyze the karyotype of the villus cells, and Immunohistochemical technique was used to detect the expression of MMP-9, TSP-1 and protein grading in villi. Results: The karyotypes of villi cell in the control group were 44+XX or 44+XY, but for karyotypes analysis, 42 cases in 98 villi samples from the study group were failed. Among the 56 villi samples successfully completed karyotypes analysis, there were 6 cases with monomer-X chromosome, 1 case with monomer normal chromosome, 35 cases with trisomy, 7 cases with chimerism, and 6 cases with chromosome deletion or duplication. The rate of positive MMP-9 of villi in the control group was significant higher than that of villi in the study group, while the expression of TSP-1 of the villus tissue in the study group was significant lower than that in the control group (P<0.05). Conclusion: Cytogenetic etiological analysis of the villi of women with missed abortion can provide guidance for the next pregnancy. The expression of MMP-9, TSP-1 of villi can be used as auxiliary diagnostic index for missed abortion.

2019 Vol. 27　(7):　902- [Abstract]（ 316 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To investigate the clinical efficacy of Nuoshu and hot ball endometrial ablation for treating women with abnormal uterine bleeding. Methods: 128 women with abnormal uterine bleeding were randomly divided into group A and group B (64 cases in each group). The women in the group A were treated by Nosuo endometrial ablation and the women in the group B were treated by hot ball endometrial ablation. The short-term or long-term clinical efficacy was evaluated. Results: The total effective rate of women in group A and B were 93.8% and 96.9, respectively, which had no significant difference (P>0.05). There were no significant difference in the average time of hospital stay, the volume of intraoperative blood loss, and the rate of postoperative fever of women between the two groups (P>0.05). The operation time of women in group B was significant longer than that of women in group A, the average vaginal discharge time of women in group B was significant shorter, and the abdominal pain rate of women in group B was significant higher (P<0.05). After treatment, the levels of RBC, HGB and hematocrit of all women increased significantly (P<0.05), but which had no significant difference between the two groups (P>0.05). There was no significant difference in the incidence of amenorrhea of women on the 1st, 4th, or 6th month after operation (P>0.05), but that of women in group A on the 12th or 18th month after operation was 54.7% and 50.8%, respectively, which was significant higher than that (29.7% and 25.0%) of women in Group B (P>0.05). Conclusion: As for treating women with abnormal uterine bleeding, Nuosuo endometrial ablation is more convenient, makes patients recovery quickly, has less treatment time, and no need to pretreatment. After Nuosuo endometrial ablation, the amenorrhea effect is more obvious with time, so it is the best treatment choice for abnormal uterine bleeding.

2019 Vol. 27　(7):　908- [Abstract]（ 337 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To explore the infection of human parvovirus B19 of pregnant women during different pregnancy stages, and to study the influence of human parvovirus B19 infection on adverse pregnancy outcomes. Methods: Human parvovirus B19 IgM of 2240 pregnant women were detected by enzyme-linked immunosorbent assay from January 2016 to December 2017. Results: The infection rate of human parvovirus B19 was 2.2%. There were no significant difference in the infection rate among pregnant women with different age, parity and number of fetuses (P>0.05). The infection rate of women in equal to or less than 12 gestational weeks was 3.5%, which was significant higher than that (1.6%) of women in 13-28 gestational weeks and that (1.8%) of women over 28 gestational weeks (P<0.05). The incidences of stillbirth, fetal malformation, fetal edema and abortion of infected pregnant women were 10.7%, 21.4%, 7.1%, and 7.14%, respectively, which were significant higher than those (0.3%, 0.2%, 0.1%, 0.6%, respectively) of women without human parvovirus B19 infection (P<0.05). There was no significant difference in adverse pregnancy outcomes of women in different gestational weeks (P>0.05). Conclusion: There is a certain proportion of human parvovirus B19 infection in pregnant women, which is associated with the adverse pregnancy outcomes, so it is necessary to strengthen the monitoring of parvovirus B19 infection in pregnant women.

2019 Vol. 27　(7):　915- [Abstract]（ 422 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To analyze the clinical characteristic of pregnant women with uterus myoma during the third trimester pregnancy, and to explore their appropriate delivery model. Methods: The data of 109 pregnant women with uterus myoma (in the study group) and 100 pregnant women without uterus myoma (in the control group) were analyzed retrospectively. Results: In the study group, there were86 women diagnosed during pregnancy and 23 women diagnosed during cesarean section (CS). The incidences of abnormal fetal position, premature delivery, postpartum hemorrhage, neonatal asphyxia of women with lower uterus and cervix myoma were significant higher than those of women with uterus body myoma (P<0.05). The incidences of premature rupture of membranes, fibroid degeneration, abnormal fetal position, premature delivery, postpartum hemorrhage of women with intramural myoma were significant higher than those of women with subserous myoma (P<0.05). The incidences of fibroid degeneration, abnormal fetal position, and postpartum hemorrhage of women with uterus myoma equal to or over 5cm were significant higher than those of women with uterus myoma less than 5cm (P<0.05). The incidences of premature delivery and postpartum hemorrhage of women with multipleuterus myoma were significant higher than those of women with single uterus myoma (P<0.05). There were no significant difference in labor progress situation, rate of postpartum hemorrhage, and neonatal asphyxia rate between the two groups (P>0.05)．In the study group, operation time, volume of bleeding during operation, and the hospital stay time, and cost of women with CS and myomectomy were significant higher than those of women with CS only (P<0.05). Conclusion: Uterus myoma maybe influences the pregnancy and delivery of women, so the myoma location, size and number of myoma should be fully considered for delivery mode choosing. It is suggested that vaginal delivery should be the first choice, and myomectomy during CS should comply with the clinical indications strictly. 

2019 Vol. 27　(7):　921- [Abstract]（ 336 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To investigate the value of semi-quantitative parameters and quantitative parameters of dynamic contrast-enhanced scanning MR for diagnosing ovarian tumors. Methods: The clinical data of 82 patients with ovarian tumor were retrospectively collected from January 2010 to May 2018. All patients underwent dynamic incremental scan to obtain semi-quantitative parameters (SI60%, TTP200s) and quantitative parameters (Ktrans, Kep, Ve value). The semi-quantitative parameters and quantitative parameters were compared between the women with benign and with malignant ovarian tumors based on the pathological diagnosis results. ROC analysis used to study the value of SI60%, TTP200s, Ktrans, Kep, and Ve value for differential diagnosing benign or malignant ovarian tumors. Results: A total of 52 women with malignant ovarian tumors and 30 women with benign tumors were detected. The TIC classification of women with benign tumors was mainly type I and type II, which was significant different from that (mainly type II and type III) of women with malignant tumor (P<0.05). The TTP200s, Ktrans, Kep and Ve values of women with benign tumor were significant higher than those of women with malignant tumor (P<0.05), but SI60% of women with benign tumor was significant lower than that of women with malignant tumor (P<0.05). The area under the curve of SI60%, TTP200s, Ktrans, Kep, Ve for diagnosing malignant ovarian tumors was 0.780 (95% CI: 0.664-0.897, P=0.000), 0.869 (95% CI: 0.7650.973, P=0.000), 0.922 (95% CI: 0.853-0.991, P= 0.000), 0.808 (95% CI: 0.699-0.917, P=0.000), and 0.872 (95% CI: 0.768-0.976, P=0.000), respectively. The sensitivity and specificity of diagnosing malignant ovarian tumors were 93.7% and 78.3% when SI60%>96.05%, and the sensitivity and specificity of diagnosing malignant ovarian tumors were 96.4% and 70.3% when TTP200>115s, the sensitivity and specificity of diagnosing malignant ovarian tumors were 87.50% and 92.35% when Ktrans>2535, the sensitivity and specificity of diagnosing malignant ovarian tumors were 78.3% and 91.1% when Kep>0.420, and the sensitivity and specificity of diagnosing malignant ovarian tumors were 69.4% and 90.3% when Ve>0.081. Conclusion: There are significant different in the values of dynamic enhanced scanning parameters (SI60%, TTP200s, Ktrans, Kep, and Ve) for diagnosing benign or malignant ovarian tumors, which are effective imaging indicators for differential diagnosis of benign or malignant ovarian tumors.

2019 Vol. 27　(7):　929- [Abstract]（ 375 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To investigate the predictive value of combined detection of serum prolactin (PRL), beta-human chorionic gonadotropin (β-HCG), and serum glycoprotein 125 (CA125) levels for the outcomes of women with threatened abortion after spuc treatment. Methods: 136 pregnant women with threatened abortion were divided into group A (110 women with continuous pregnancy) and group B (26 women with inevitable abortion), and other 80 normal pregnant women were selected in group C. All included women were received serum PRL, β-HCG and CA125 levels detected, and the predictive value of combined detection of serum PRL, β-HCG and CA125 for the outcomes of women with threatened abortion after spuc treatment were analyzed. Results: The serum levels of PRL and β-HCG of women in group A and B were significant lower than those of women in group C, and those of women in group A were significant lower than those of women in group B, but the level of CA125 of women in group A and B was significant higher than that of women in group C (P<0.05). The levels of PRL and-HCG of women in 5, 7 and 9 gestational weeks in group A were significant lower than those of women in group B, but the level of CA125 of women in group A and B was still significant higher than that of women in group C (P<0.05). The sensitivity, specificity and accuracy of combined detection of PRL, β-HCG and CA125 levels for diagnosing inevitable abortion of women with threatened abortion after spuc treatment were 89.2%, 93.4% and 89.9%, respectively, which were significant higher than those of level detection of PRL, beta-HCG or CA125 alone (P<0.05). Conclusion: Combined detection of serum PRL, β-HCG and CA125 levels of women with threatened abortion during the first trimester pregnancy has high predictive value for inevitable abortion.

2019 Vol. 27　(7):　937- [Abstract]（ 371 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To explore the changes and influencing factors of vitamin A (VA) of pregnant women during pregnancy, and to provide evidences for rational VA nutrition treatment. Methods: A total of 5104 pregnant women who accepted antenatal check-ups were selected to finish the questionnaires from April 2015 to February 2017, and their serum samples during different pregnant periods were collected and detected for knowing their VA levels. Results: The proportion of abnormal serum VA level of the pregnant women was 10.7%, which included VA deficiency accounted for 9.7% and VA excess accounted for 1.0%. The proportion of VA deficiency of women during the third trimester pregnancy was high (18.5%). The single risk factor of VA deficiency of women during the first trimester pregnancy was pregnancy vomiting, threatened abortion, history of infectious gastroenteritis, or partial eclipse. The single risk factor of VA deficiency of women during the second trimester pregnancy was gestational diabetes, intake related foods (animal liver, milk and broccoli, etc.), or oral related drugs. The single risk factor of VA deficiency of women during the third trimester pregnancy was body mass index, anemia, gestational diabetes, hypertensive disorders during pregnancy, or partial eclipse. Multivariate logistic regression showed that the risk factor for VA deficiency during the first and third trimester pregnancy was partial eclipse, and the risk factors during the second trimester pregnancy were taken related foods and drugs (P<0.05). Conclusion: The VA level of pregnant women has differences during different trimester pregnancy, and VA deficiency is common in pregnant women, so VA reasonable supplements is benefit for maternal and child safety.

2019 Vol. 27　(7):　945- [Abstract]（ 308 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

Objective: To investigate the blood trace elements levels of pregnancy women with different age during the first and second trimester pregnancy, and to provide evidences for the reasonable and safe supplementation of trace elements of pregnant women. Methods: 6620 health pregnant women aged 20-39 years were divided into group A (2530 cases during the first trimester pregnancy ) and group B (4090 cases during the second trimester pregnancy), and other 200 health women without pregnancy were selected in group C. The blood copper, zinc, calcium, magnesium and iron of all included women were tested. Results: There were no significant different in the blood calcium and magnesium between pregnant women and non-pregnant women (P>0.05), but the blood copper level of women in group A and B was significantly higher than that of women in group C, and the levels of blood zinc and iron in group A and B were significant lower than those of women in group C (P<0.05). In group A and B, the blood copper level of women with 26-36 years old and ≥36 years old were significant higher than that of women with ≤25 years old (P<0.05). In group B, the blood iron level of women with 26-36 years old and ≥36 years old were significant lower than that of women with ≤25 years old (P<0.05). The rate of low iron level of women in group A and B was 16.1% and 27.8%, respectively, which was significant different from that of women in group C (P<0.01). The rate of low zinc level of women in group A and B was 5.8% and 9.6%, respectively, which was significant different from that of women in group C (P<0.01). The rate of low calcium level of women in group A and B was 4.97% and 4.96%, respectively, which was significant different from that of women in group C (P<0.05). Conclusion: In order to meet the needs of mothers and fetuses, it should be supplemented trace elements according to the characteristics of different trace elements levels of pregnant women in different ages during different pregnant stage.

2019 Vol. 27　(7):　952- [Abstract]（ 265 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )