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| Curative efficacy of aspirin combined with progesterone for treating women with polycystic ovary syndrome and its influence on the levels of serum DHEAS, adropin and MCP-1 |
| The Second Hospital of Tianjin Medical University, Tianjin, 300210 |
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Abstract Objective: To explore the curative efficacy of aspirin combined with polycystic ovary syndrome, and to study its influence on the levels of serum dehydroepiandrosterone sulfate (DHEAS), adropin protein (adropin) and monocyte chemoattractant protein-1 (MCP-1). Methods: 257 women with polycystic ovary syndrome were included and divided into the observation group (137 cases) and the control group (120 cases) by the random number table from January 2015 to January 2018. The women in the control group were treated by progesterone combined with clomiphene for 3 menstrual cycles, and the women in the observation group were treated by aspirin combined with clomiphene for 3 menstrual cycles. The effects and adverse reactions of women were compared between the two groups. Results: After treatment, the levels of serum DHEAS, MCP-1, follicular estrogen (FSH), and luteinizing hormone (LH) of women in the observation group were significant lower than those of women in the control group, but the level of adropin was significant higher than that of women in the control group (P<0.05), and the endometrium of women in follicular phase, ovulation phase, and luteal phase were significant thicker than those of women in the control group (P<0.05). Six months after treatment, the ovulation rate and pregnancy rate of women in the observation group were significant higher than those of women in the control group (P<0.05), but there was no significant difference in the incidence of adverse reaction between the two groups (P>0.05). Conclusion: Aspirin combined with progesterone for treating women with polycystic ovary syndrome can improve the efficacy, which can effectively regulate the serum DHEAS, adropin and MCP-1 expression of women, and can improve the thickness of endometrium and increase the pregnancy rate of women.
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