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Abstract Objective: To investigate the influence of lymphatic vessel infiltration (LVSI) on 5-year survival rate of patients with cervical cancer. Methods: 98 patients with cervical cancer (FIGO stage IA2-IIA) who underwent surgery from January 1, 2012 to December 31, 2014 were enrolled in the study. Postoperative pathological LVSI was observed, and the end point of followed-up was to death. The relationship between LVSI and clinical data, and the relationship between pathological data and overall survival rate were analyzed. Results: In the 98 patients, 48 cases were positive LVSI, and positive LVSI was associated with cervical cancer differentiation, lymph node metastasis, and depth of invasion (P<0.05). 7 patients (3 cases with positive LVSI and 4 cases with negative LVSI) were lost to follow up, and the followed up rate was 92.9%. The median followed up time was 68 months (50-86 months), the 5-year survival rate of patients with positive LVSI was 71.4%, and the 5-year survival rate of patients with positive LVSI was 60.0%, which was significant lower than that (82.6%) of patients with negative LVSI (P<0.05). Kaplan-Meier analysis showed that patients with positive LVSI had lower survival time than that of patients with negative LVSI (P<0.05). LVSI (P<0.05, OR: 1.155, 95% CI: 1.1975.698), tumor differentiation (P<0.05, OR: 1.324, 95% CI: 1.0742.981), and lymph node metastasis (P<0.05, OR: 2.098, 95% CI: 1.4556.949) were independent prognostic factors influenced the overall survival of patients with cervical cancer. Conclusion: LVSI of patient with early cervical cancer is related to the degree of differentiation, lymph node metastasis and depth of invasion. The survival rate of patients with positive LVSI is low, and their prognosis is poor. LVSI can be as the indicator for predicting the prognosis of patient with cervical cancer early.
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