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ZHANG Wen, WANG Kun, WU Shangchun
Objective: To evaluate menstrual bleeding patterns after insertion of medicated GyneFix intrauterine device (IUD) when compared with other products of GyneFix series and the contraceptive efficacy when used in special circumstances. Methods: We searched medical databases including CNKI (1979-2014), CBMdisc (1978-2014), Wanfang Database (1982-2014), VIP Database (1989-2014) by computer. And we screened the articles and then performed a meta-analysis by using RevMan5.0 software. Results: Seven articles from 580 literature were recruited for meta-analysis according to inclusion and exclusion criteria. The analysis results showed that incidences of menorrhagia, prolonged menstrual bleeding, spotting bleeding of medicated GyneFix IUD were generally lower than those of GyneFix IN and GyneFix soft threads IUDs. The expulsion rate and the removal rate for medical reason of medicated GyneFix IUD immediately inserted after abortion were lower than those of Gong copper 200 IUD. Among women with cesarean history, the pregnancy rate with IUD in situ, the expulsion rate and the removal rate for medical reason of medicated GyneFix IUD were lower than those of Yuangong copper 220 or copper T 220C IUDs, while the expulsion rate and the removal rate for medical reason of medicated GyneFix IUD were lower than those of copper T 380A IUD. Conclusion: Medicated GyneFix can improve the menstrual bleeding pattern, also it can prevent the pregnancy effectively, reduce the expulsion rate and the removal rate for medical reason even when used in special circumstances. So it has the favorable contraceptive efficacy and is worth using widely.
2014 Vol. 22 (12): 793- [Abstract]（
81
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DING Nan, WANG Fang, JIAN Qiliang,et al
Objective: To systematically evaluate associations between ureaplasma urealyticum (Uu) infection and chlamydia trachomatis (Ct) infection with female infertility. Methods: According to the strict inclusive and exclusive criteria, CNKI, CBMdisc, Wanfang, VIP and PubMed databases were searched. Furthermore, we manually searched the relevant references published from 2000 to 2014. Two reviewers selected trials and assessed trial quality independently by using the Cochrane Handbook 5.3. A meta-analysis was performed with the fix-effects model or random-effects model according to the heterogeneity. Results: A total of 181 relevant studies, involving 132 Chinese studies and 49 foreign studies were retrieved. Eventually, 13 eligible Chinese studies involving 3760 patients were included. The results of the meta-analysis were as follows: The merged odd ratio (OR) of Uu, Ct and (Uu + Ct) were 6.41 (95%CI: 4.85-8.47), 6.76 (95%CI: 5.33-8.58) and 10.74 (95%CI: 6.87-16.81), respectively. The incidences of infertility in all groups were different when compared with the corresponding control groups. Conclusion: There are significant associations between Uu and Ct infections with female infertility, suggesting that we should pay enough attention to the detection in infertile women with Uu and Ct infections.
2014 Vol. 22 (12): 803- [Abstract]（
67
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WU Lingxia, CHEN Hongbo, LI Dan, et al
Objective: To explore the current status of reproductive health knowledge among women seeking induced abortion in order to provide the evidence for improving quality of service in post-abortion family planning. Methods: A cross-sectional survey was conducted among 836 women (15 to 45 years old) seeking induced abortion in 4 hospitals in Xuhui District of Shanghai. Results: The respondents' scores of reproductive health knowledge were low and the average score was 8.27±3.52. The awareness of appropriate contraceptives was low, which was relevant to the age, educational level and occupation. The positive correlation was found between the awareness of contraceptive and age as well as the educational level in unmarried women. The recurrent induced abortion rate of the respondents was 58.4%, which was related to the educational level of their partners （χ2=10.90，P<0.05）besides their age (χ2=27.77，P<0.05) and the educational level (χ2=23.29，P<0.05). Conclusion: The post-abortion family planning services in hospitals should be normalized. Meanwhile，an involvement of male partner should be advocated. The publicity education of family planning should be carried out according to the characteristics of population distribution.
2014 Vol. 22 (12): 808- [Abstract]（
80
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WANG Lequn, LYU Tu, HAN Qingrong,et al
Objective: To explore the status of urogenital system disorders of childbearing-aged men and the effect of psychological factors, so as to provide a scientific basis for targeted intervention. Methods: A total of 3933 men aged 18 to 59 were randomly chosen according to age. A questionnaire survey was conducted and urogenital system disorders of the respondents were diagnosed with the related physical examination in the hospital. Results: The positive rate of urogenital system symptoms was 50.65%, which was related to the psychological stress, work and economic pressures and selfhealth awareness of the respondents (P<0.001). The incidence of prostatic hyperplasia was 18.28%, and the high economic pressure (OR=1.229，P<0.001) and the poor selfhealth awareness (OR=1.089，P<0.05) were its risk factors. The positive incidence of prostatitis was 14.59%, the excessive anxiety (OR=1.167，P<0.05), the high economic pressure (OR=1.103, P<0.05) and poor selfhealth awareness (OR=1.302, P<0.001) were risk factors of prostatitis. Conclusion: The prevalence of urogenital system disorders of childbearingaged men in the three-gorges region is higher. Psychological factors such as excessive anxiety, high pressures and selfhealth awareness are related to the reproductive system disorders of childbearingaged men.
2014 Vol. 22 (12): 813- [Abstract]（
65
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CHEN Hua, YANG Liming, SUN Qiao,et al
Objective: To analyze birth characteristics of migrant population and resident population in Pudong New District, Shanghai and to provide a reference for maternal and child health management, disease control and prevention policies. Methods: A describing analysis on birth characteristics was conducted using monitoring data from the birth registration system. Results: In migrant population, the sex ratio at birth was 119.67, the cesarean section rate was 43.87％, the incidence of fetal macrosomia was 7.93％, the incidence of low birth weight was 3.23％. The incidences of fetal macrosomia and low birth weight in migrant population were higher than those in resident population. The reporting rate of birth defects in migrant population was 10.51‰, which was higher than that in resident population. Conclusion: It is necessary to be strengthened that the concept of gender equality and the education on health birth and child development in migrant population. And the prenatal health service and health resource of migrant population should be provided.
2014 Vol. 22 (12): 817- [Abstract]（
77
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LI Li, WANG Chen, ZOU Yan, et al
Objective: To observe the clinical effectiveness of Yuangong copper 300 (YGCu300), copper T 380A (TCu380A) and medicated copper ring 165 (MCR165) intrauterine devices (IUDs), and to explore the way to improve their use. Methods: A randomized, comparative, multi-centre clinical trial was performed between July 3, 2007 and November 21, 2008. Totally 3299 eligible women were recruited and administered three types of IUDs randomly during their intermenstrum. Results: Among the 3299 women, 8(0.24%) were excluded because of uncompleted the first year-follow up. There were 1104, 1104 and 1091 cases were inserted YGCu300, TCu380A and MCR165 IUDs, respectively. By the end of the first year, the pregnancy with IUD in situ among three groups were no significantly differences (P＞0.05). The discontinuation rates of all expulsion of the three groups were similar(P＞0.05). The rate of the total expulsion of MCR165 IUD (2.09 per hundred women year) was the highest, and there was significant difference between it and YGCu300 (0.84 per hundred women year) and TCu380A IUDs (0.75 per hundred women year) respectively (P＜0.05). Four cases of unwanted pregnancy were found in the group of MCR165 IUD. The medical removal rate for bleeding/pain of three types of IUDs were 4.67 per hundred women year, 2.61 per hundred women year and 1.61 per hundred women year, showing significant differences among three groups (P＜0.05). Conclusion: The three types of IUDs have different advantages and shortcomings. We should choose IUD for women according to their situation and the characteristic of IUD, and to improve the actual value of IUD in use.
2014 Vol. 22 (12): 821- [Abstract]（
104
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SU Zhixia, WANG Ning
Objective: To explore the anesthetic effect of dezocine combined with propofol in oviduct ligation. Methods: Two hundred patients were randomly divided into two groups. Women in group A (n=100) was treated with 1% lidocaine local anesthesia injections, and those in group B (n=100) was treated with 5 mg of dezocine combined with 2 mg/kg of propofol besides 1% lidocaine local anesthesia injection. Systolic pressure (SBP), diastolic pressure(DBP), oxygen saturation (SPO2), heart rate (HR),electrocardiograms and the duration of operation as well as the number of pulling fallopian tube at different points in time were evaluated. Results: Compared with group A, SBP, DBP, SPO2, HR at different points in time showed more stable in Group B (P<0.05), and shorter operation time and fewer pulling were found in Group B (P<0.01). Conclusion: The use of dezocine combined with propofol in oviduct ligation is safe and efficient, and can be applied in clinical practice.
2014 Vol. 22 (12): 827- [Abstract]（
59
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JIA Boqin, SONG Xueru, ZHAO Xiaohui, et al
Objective: To explore the effect of preventative control of serum thyrotropin levels at less than 2.5 mU/L on early pregnancy with in vitro fertilization /intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET). Methods: A study was performed on 181 infertility patients undergoing initial IVF/ICSI-ET because of simple fallopian tubes factor or male factor from March 31, 2013 to March 31, 2014. The concentrations of serum free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were evaluated at first visit and a month before the beginning of IVF/ICSI-ET treatment. The patients with TSH levels between 2.5 mU/L and 5.0 mU/L were randomly divided into two groups. Women in group A (n=42) did not use L-thyroxine tablets (L-T4), TSH level in those of group B (n=34) were lowered at less than 2.5 mU/L after the use of L-T4, and TSH level in those of group C was not more than 2.5 mU/L in at least two measures (n=105). The outcomes of IVF/ICSI-ET for each group were compared. Results: Age, gonadotropins dosage, number of oocyte, endometrial thickness, fertilization rate, embryo quality rates, number of embryo transferred and biochemical pregnancy rate had no statistically significant differences among three groups (P>0.05); Embryo implantation rate and clinical pregnancy rate of group A (27.9%, 45.2%) were lower than those of group B (49.2%, 79.4%) and group C (42.9%, 65.7%); Trimester miscarriage rate of group A (31.6%) was higher than those of group B (7.4%) and group C (11.6%), showing statistically significant differences (P<0.05). Conclusion: Patients with TSH levels between 2.5mU/L and 5.0mU/L lowered at less than 2.5mU/L after the prophylactic use of L-T4 has a positive effect on early pregnancy of IVF / ICSI-ET.
2014 Vol. 22 (12): 830- [Abstract]（
55
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Wang Juan, LI Shenghua
Objective: To investigate therapeutic effects of high intensity focused ultrasound (HIFU) combined with traditional Chinese medicine in the treatment of vulva leukoplasia. Methods: A clinical observation was carried out in 155 patients with vulva leukoplasia from January 2008 to November 2012. They were divided into three groups. Women in group A and B were treated by HIFU+drugs (n=55) and HIFU only (n=55), respectively. A total of 45 women were served as the control. There were no statistically significant differences in age, degree of lesions (P>0.05). Clinical effects were evaluated among three groups. Results: The effective rates of group A(92.7%,51/55) and group B(96.4%,53/55) were better than that of the control group (66.7%,30/45,P<0.05), and the effective rate of group A was the best. The adverse reaction rate of group A was 3.6%, while that of group B was 18.2%. There was statistically significant difference between the two groups (P<0.05). The recurrence rates of group A(1.8%,1/55) and B(7.3%,4/55) were lower than that of the control group (55.6%,25/45,P<0.05). Conclusion: HIFU combined with traditional Chinese medicine was a noninvasive, fast, safe and repeatable method in the treatment of vulva leukoplasia.
2014 Vol. 22 (12): 834- [Abstract]（
47
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LI Chunxiao, WANG Yankun, NING Meiying
Objective: To establish high-performance liquid chromatography (HPLC) method for the detection of related substances in compound gestodene intravaginal ring. Methods: The separation and determination were accomplished on the HPLC with a column of Diamonsil C18 (250 mm ×4.6 mm，5μm) and UV detection at 239, 205nm for gestodene and ethinyloestradiol respectively．The mobile phase consisted of acetonitrile and water (50:50) at a flow rate of 1.0 ml/min. Results: Specificity test results showed that gestodene, ethinyloestradiol and related impurities, degradation products were well separated, while blank accessories had no interference for determination, Gestodene and ethinyloestradiol detection limits were 4 ng/ml and 5 ng/ml, The reproducibility was good for RSD were 1.6% and 1.3%. Conclusion: The method used for detection of related substances in compound gestodene intravaginal ring is easy to operate and has specificity, high sensitivity and good producibility.
2014 Vol. 22 (12): 837- [Abstract]（
57
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