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Chinese Journal of Family Planning

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  • 2014 Volume 22 Issue 7
    Published: 15 July 2014
      
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  • Interlaboratory comparison on quality control of clinical biochemical laboratory in family planning institute of Guangdong Province
    JIANG Min, PANG Tao, MIAO Zhulin, et al
    2014, 22(7): 436.
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    Objective: To explore the status of clinical biochemical quality by comparative analysis of quality control data of clinical biochemical laboratory at all levels of family planning agencies in Guangdong Province. Methods: Results of the clinical biochemical testing with the same batch of regent for quality control in 19 laboratories in family planning agencies of Guangdong Province were compared. Coefficient of variation (CVI) and standard deviation index (SDI) were used for the evaluation of the precision and the accuracy. Results: According to the results of the comparison of evaluation，the qualification rates of CVI and SDIin the alanine aminotransferase examination were 100.00% and 95.60% respectively, those in the creatinin examination were 97.70% and 97.70% respectively，and those in the glucose examination were 97.80% and 93.30% respectively. Conclusion: It could benefit for monitoring and improving the examination quality of clinical biochemical laboratory of all family planning agencies by evaluating the result of the internal quality control with interlaboratory comparison.
  • Personnel training and standardization of laboratory construction in national free preconception health examination project
    LAI Li-hua, ZHANG Li-ping, LIAO Yun-feng
    2014, 22(7): 440.
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    Objective: To explore the personnel training for rapidly improving examination quality and management in laboratories at the grass-roots level. Methods: The status of the personnel professional quality structure, inspection items, instruments and reagents of family planning service agencies affiliated to Chongqing were investigated. Writing teaching materials, organizing the theoretical and operation training, developing the standardized laboratory verification table, site inspection and guidance as well as the comparison of examination results were conducted. Results: The average score of theoretical examination of laboratory technicians increased after the training. The standardization of the laboratory construction was improved year by year. Conclusion: Through research, training, on-site inspection guidance, and training-site inspection instruction mode of circulation, the levels of theoretical knowledge and manipulative skills of the personnel in laboratories of the grass-root family planning technical service institutions could be improved quickly and effectively, and the standardization construction of these laboratories could be promoted effectively.
  • Analysis of growth hormone receptor gene detected by multiplex ligation-dependent probe amplification in children with short stature
    QIU Ming-hui, DONG Guo-qing, LU Xi-yan, et al
    2014, 22(7): 443.
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    Objective: To explore growth hormone receptor (GHR) gene polymorphism in children with short stature. Methods: Blood samples were collected in 96 children with short stature, who were divided into growth hormone deficiency (GHD) group (n=67) and idiopathic short stature (ISS) group (n=29). Meanwhile, blood samples were collected in 23 health children as control group. The GHR gene (10 exons) of all the children were detected by multiplex ligation-dependent probe amplification (MLPA), and the growth hormone receptor (GHR) gene polymorphism were analyzed through gene-marker software. Results: No signal anomalies were found in GHR gene exon 1, 2 and 4 to 10. The detection rates of fl/d3 and d3/d3 of growth hormone receptor were 34.3%, 1.5% in GHD group, 17.2%, 3.4% in ISS one and 26.1%,8.7% in the controls. There were significant differences of GHR genotype and the allele frequency distribution among these three groups. Conclusion: GHR gene exon 3 deletion is the polymorphism in the children with short stature and health children. The influence of GHR gene on the height of children and their specific biological function remain to be further explored.
  • Expression of galanin in the testis and epididymis of adult mouse
    〗SHI Cui-ge, WANG Li-li, LI Hui, et al
    2014, 22(7): 448.
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    Objective: To study the expression and localization of galanin in testis and epididymis of adult mice, and to explore the role of galanin in male reproductive organs in mice. Methods: The expressions of galanin were detected in both testis and epididymis by immunohistochemical staining. Results: Galanin was expressed in testis and epididymis of adult mice. In the testis，galanin immunoreactive particles were found in interstitial cells, sertoli cells and spermatogenic cells, and mainly in the membrane and cytoplasm. And in the epididymis, galanin was presented in epididymal duct tall columnar cells, low columnar cell membrane and cytoplasm. The galanin expression in the epididymis body and tail were higher than that of the epididymis head. Conclusion: Galanin is presented in testis and epididymis of the mature mouse and its physiological function remains to be elucidated.
  • Sex education among college students based on influential factors of geographical sexual networks
    YANG Yi, LIAO Rui, WANG Hua-ping, et al
    2014, 22(7): 451.
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    Objective: To analyze the characteristics of college students' geographical sexual networks, so as to give references for the following sex education. Methods: Questionnaires were used to investigate 4081 students about their geographical sexual networks, multinomial logistic analysis was applied. Results: About 13.8% respondents reported that they had sexual intercourse. Corresponding, 37.1% and 21.8%, and 28.3% and15.9% reported that their first sexual intercourse and sexual intercourses in past half year happened and most happened in hotels/inns nearby and far away from their universities. The places of first sexual intercourse were influenced by university locations (P<0. 05), and places of sexual intercourses in past half year were influenced by grade, in love and the places of first sexual intercourse (P<0.01). Conclusion: Based on the characteristics of college students' geographical sexual networks, and focusing on the places where sexual intercourses happen, sex education will be more practical.
  • The clinic effectiveness of standardized informed choice on IUD use
    HONG Ying, LUO Ke-mei, XIE Li-chun
    2014, 22(7): 455.
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    Objective: To investigate the impact of standardized informed choice on the use of intrauterine device (IUD) in order to provide scientific basis for improving service quality. Methods: From October 2011 to September 2012, 650 women with IUD insertion were served standardized informed choices by doctors (including preoperative counseling, postoperative health education and regular follow up 1, 3, 6, 12 months after the operation). And 645 women with IUD insertion (October 2010 to September 2011) at the same station were as the control. The infection rate after IUD insertion, removal rate due to side effects, the expulsion rate, pregnancy rate and continuation rate were evaluated. Results: Postoperative initiative follow-up rates increased, the removal rate due to bleeding significantly reduced, and the cumulative continuation rate improved significantly. Conclusion: Standardized informed choice can improve the client's compliance, reduce the removal rate of IUD due to side effects, and increase the cumulative continuation rates.
  • Effect of Bushen Tiaojing Decoction on nephrasthenia anovulatory infertility
    ZHANG Jin-ting, DU Shu-ying, WANG Ning, et al
    2014, 22(7): 460.
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    Objective: To evaluate the effect of "treatment from kidney"  by evaluating the effect of Bushen Tiaojing Decoction on nephrasthenia anovulatory infertility. Methods: By using a case-control and self-control study, 167 women with nephrasthenia anovulatory infertility were recruited for three treatment cycles and 3 follow-up cycles. Fifty-five women in the western medicine group took clomiphene citrate, and 112 women in the traditional Chinese and western medicine group were treated with clomiphene and Bushen Tiaojing recipe. Results: The degree of improvement of the clinical signs and symptoms in the traditional Chinese and western medicine group (83.0%) was significantly higher than that of the western medicine group (43.6%, P<0.01), the total pregnancy rate in the traditional Chinese and western medicine group (69.6%) was significantly higher than that of the western medicine group (41.8%, P<0.01), the pregnancy rate per cycle (23.0%) in the traditional Chinese and western medicine group was significantly higher than that of the western medicine group (14.2%, P<0.05), the percentage of women with normal menstrual cycle (82.0%) in the traditional Chinese and western medicine group was significantly higher than that of the western medicine group (71.1%, P<0.05), and the percentage those with ovulation disorder in the traditional Chinese and western medicine group (25.9%) was significantly lower than that of the western medicine group (44.7%, P<0.01), and the endometrial developments on the day of LH-6 to LH +1 in the traditional Chinese and western medicine group were significantly better than those of clomiphene group (P< 0.05 to 0.01). Conclusion: Bushen Tiaojing recipe plays a role in the physiological processes of menstruation, ovulation, endometrial rehabilitation, showing the advantage of  "treatment from kidney" with traditional Chinese medicine.
  • Clinical research of mifepristone capsules combined with dinoprostone in preterm labor induction of late pregnancy
    XU Ya-juan, ZHAI Shan-shan,YANG Pei-feng, et al
    2014, 22(7): 465.
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    Objective: To evaluate the clinical effect of mifepristone capsules combined with dinoprostone in preterm labor induction of late pregnancy. Methods: According to different ways of abortion, late pregnancy women who had preterm induced labor indications were divided into 3 groups. Women in Group A were placed dinoprostone in the posterior fornix, and those in group B took mifepristone capsules combined with intravenous drip of oxytocin, and those in group C received mifepristone capsules combined with dinoprostone. The effects of induced labor of the three groups were evaluated. Results: There were no significant differences in age, gravidity, duration of pregnancy, fetal weight, cervical Bishop score among three groups before the treatment (P all>0.05). Compared with group B and group A, higher cervical Bishop scores 6h and 12h after the treatment, shorter contraction start time, shorter labor stage, less postpartum bleeding and higher successful rate of induced labor were found in group C (P all <0.05). The curettage rate was lower in group C than group A (P<0.05), while similar with that of group B (P>0.05). Conclusion: Mifepristone capsules combined with dinoprostone is superior to the other methods in preterm labor induction of late pregnancy.
  • Clinical observation on controlled-release prostagland E2 in abortion in different times
    Zhao Wei
    2014, 22(7): 468.
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    Objective: To investigate the effectiveness and safety of using controlled-release prostagland E2 in abortion in different times. Methods: A total of 129 primiparas with delayed pregnancy (gestational age > 40 weeks) or prolonged pregnancy (gestational age > 42 weeks) between January 2011 and February 2013 in our hospital were recruited. There was no head disproportion phenomenon in all of the pregnant women. The pregnant women with no serious underlying disease and medication contraindications were divided into three groups randomly (43 women in each group). Propess was placed in the posterior fornix for induction of labor in the observation group, misoprostol was placed in the posterior fornix for induction of labor in control group 1, and women in control group 2 were given oxytocin for abortion. Both the change of cervical ripening and the induction effect as well as adverse reactions were compared among three groups. Results: The cervical scores of pregnant women in three groups had no significant difference before treatment (P>0.05), and cervical scores gradually increased in three groups as the treatment time extents, but that in the observation group was significantly higher than those of both control group 1 and control group 2 after treatment for 12 h. The time interval between using medicine to labor and total stage of labor were significantly shorter in the observation group, and the successful rate of the induction (93.02%) in the observation group were significantly higher than those of the control group 1 (66.67%) and the control group 2 (48.89%). Women in the observation group had no adverse reactions during the induction process, while the incidence of complications was 6.67% and 15.56% in the control group 1 and the control group 2, respectively (P<0.05). Conclusion: The use of Propess in abortion of postponed or prolonged pregnancy can significantly increase the induction effect, and it is a fast, effective and safe abortion medicine, which can be widely applied clinically.
  • Different diagnostic criteria of gestational diabetes Mellitus
    CAI Ye-ping, DENG Li-zhen, LI Rong-tao
    2014, 22(7): 471.
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    Objective: To investigate the relationship between different diagnostic criteria of gestational diabetes Mellitus (GDM) and perinatal outcomes. Methods: The clinical data of pregnant women who had routine prenatal examine and delivery in our hospital from June 2012 to May 2013 and June 2011 to May 2012 were analyzed. They were diagnosed GDM according to International Association of Diabetes and Pregnancy Study Groups (IADPSG) standard (n=3216 IADPSG group) or according to National Diabetes Data Group (NDDG) standard (n=2985, NDDG group). The incidence of GDM, maternal complications and perinatal outcomes of women with GDM were evaluated. Results: The incidence of GDM in IADPSG group (15.73%, 506/3216) was significantly higher than that in NDDG group (5.46%, 163/2985). The incidences of preeclampsia, intrahepatic cholestasis of pregnancy and amniotic infection in NDDG group were significantly higher than those of IADPSG group (P all< 0.01). The incidences of premature and neonatal asphyxia in NDDG group were significantly higher than those of IADPSG group (P<0.01). Conclusion: Compared with NDDG group, the incidence of GDM is significantly higher in IADPSG group. The diagnosis of GDM using IADPSG standard has important implications for reducing the adverse perinatal outcomes, such as preeclampsia, amniotic infection, premature delivery and neonatal asphyxia.