To investigate the correlation between the marital adjustment and the ruminative reflection of male partners in the couples with in vitro fertilization-embryo transfer (IVF-ET) and their frustration. Methods: A total of 262 male partners in the couples with IVF-ET in the reproductive medicine center of the hospital from February 2024 to September 2024 were selected as the study subjects. During the treatment, the baseline characteristics, the frustration, the marital adjustment and the ruminative reflection of these male partners were assessed by the baseline information questionnaire, Chinese version of Frustration Scale, Locke-Wallace Marital Adjustment Test (MAT) and Chinese version of Event-Related Rumination Inventory (C-ERRI). Pearson correlation coefficient model was used to observe the correlation between the marital adjustment and the ruminative reflection of the male partners in the couples with IVF-ET and their frustration. Multiple linear regression model was applied to analyze the factors influencing the frustration of the male partners. Results: The scores of the frustration, the marital adjustment, the intrusive rumination and the deliberate rumination of 262 male partners were 18.04±5.29 points, 109.86±16.05 points, 16.59±5.47 points, and 12.64±4.82 points, respectively. There were significant differences in the frustration scores among the male partners with different residence, among the male partners with different education level, between the male partners with and without child, among the male partners with different previous treatment time, among the male partners with different cognition for IVF-ET and between the male partners with and without history IVF-ET (P<0.05). Pearson correlation coefficient model analysis showed that the frustration of the male partners in the couples with IVF-ET was negatively correlated with their marital adjustment and was positively correlated with their intrusive rumination (all P<0.05). Multiple linear regression model analysis showed that the previous treatment time ≥3 years, the IVF-ET history and the intrusive rumination of the frustration of the male partners in the couples with IVF-ET were their positive predictive factors, and the marital adjustment of the frustration of the male partners in the couples with IVF-ET was a negative predictive factor. After R2 of the model was adjusted to 0.627, 62.7% variation causes of the frustration of the male partners in the couples could be explained (P<0.05). Conclusion: The marital adjustment and the intrusive rumination of the male partners in the couples with IVF-ET are associated with their frustration, and the established multiple linear regression model can effectively explain the variations causes of the frustration of the male partners.

To investigate the family function of women with recurrent spontaneous abortion (RSA) by cross-sectional study, and to analyze of the related the factors influencing the family function of the women. Methods: A total of 102 women with RSA who visited the hospital from October 2021 to December 2024 were selected in study group, and another 102 normal pregnant women without the history of abortion who underwent pre-pregnancy check-ups were selected in control group during the same period. A self-designed basic data questionnaire and the family Apagar index scale (APGAR) were used in this investigation. Results: The total score of APGAR of the women in the study group (5.72±2.06 points) was significantly lower than that (8.25±1.33 points) of the women in the control group. The proportion of good family function (39.2%) of the women in the study group was significantly lower than that (60.8%) of the women in the control group (all P<0.05). Among the women with RSA, the proportions of the aged ≥35 years old, the permanent residence in rural area and the remarriage of the women with family dysfunction were significantly higher than those of the women with good family function (P<0.05). There was no significant difference in the education level between the women with family dysfunction and the women with good family function (P>0.05). Multivariate logistic regression analysis showed that the age ≥35 years old and the permanent residence in rural areas of the women with RSA were the independent risk factors of their family dysfunction (P<0.05), but the remarriage of the women with RSA was not independently correlated with their family dysfunction (P>0.05). Conclusion: The women with RSA are more prone to the family dysfunction, especially for those women with the advanced age or with the permanent residence in rural areas, and the risk of their family dysfunction will further increase.

To investigate the perceived stress status of primiparas during delivery, and to analyze its influencing factors. Methods: A retrospective study was used to extract the clinical data of 100 primiparas who had been examined in the hospitals from June 2023 to May 2024. The results of the perception pressure survey of the primiparas evaluated by the Chinese version of the perception pressure scale (CPSS) were retrieved through the hospital information system, and the influencing factors of the perception pressure survey of the primiparas were analyzed. Results: A total of 100 primiparas were included in this study and their CPSS score was 27.8±6.8 points (11-47 points), of which, there were 72 (72.0%) cases with CPSS score ≥26 points in the study group and 28 cases with CPSS score <26 points in the control group. The proportions of the dissatisfaction with the subjective income (59.7%), the unplanned pregnancy (65.3%), the exercise time <30 min/d (52.8%), the family dysfunction (36.1%) and the lack of maternal-fetal attachment (48.6%) of the primiparas in the study group were significantly higher than those (17.9%, 28.6%, 14.3%, 7.1% and 17.9%) of the primiparas in the control group (all P < 0.05). Multivariate logistic regression analysis showed that the family dysfunction, the lack of maternal-fetal attachment, the dissatisfaction of the subjective income, the unplanned pregnancy and the exercise time <30 min/d of the primiparas were the factors influencing their perceived stress during delivery (all P<0.05). Conclusion: A total of 100 primiparas surveyed in this study have generally perceived stress of delivery. The family dysfunction, the lack of maternal-fetal attachment, the subjective income dissatisfaction, the unplanned pregnancy and the exercise time <30 min/d of the primiparas are the main factors influencing their perceived stress during delivery.

To investigate the efficacy of the combined estradiol valerate, letrozole and progesterone for treating patients with polycystic ovary syndrome (PCOS) complicated with infertility, and to study their influence on the endometrial thickness, the hormones levels and the pregnancy outcomes of the patients. Methods: A total of 164 infertility patients with PCOS who were admitted to the hospital were selected and were divided into control group (82 patients with the treatment by estradiol valerate and progesterone) and observation group (82 patients with the treatment by the combined estradiol valerate, letrozole and progesterone) by the random number table method from March 2020 to March 2024. The clinical efficacy, the endometrial receptivity, the sex hormones levels, the ovulation status and the pregnancy outcomes of the patients were compared between the two groups. Results: After treatment, the total effective rate (93.9%), the endometrial thickness (10.06±0.59mm), the proportion of endometrial type A (82.9%), the estradiol level (26.13±3.24 pg/L), the clinical pregnancy rate (30.5%) and the fetal protection success rate (80.0%) of the patients in the observation group were significantly higher than those (81.7%, 9.72±0.63mm, 67.1%, 24.09±3.37 pg/L, 17.1% and 33.3%) of the patients in the control group. The values of the pulsatility index and the resistance index of the endometrial snail artery, the levels of progesterone, testosterone, follicle stimulating hormone and luteinizing hormone, the biochemical pregnancy rate and the failure rate of fetal protection of the patients in the observation group were significantly lower than those of the patients in the control group. The follicle growth time and the time from treatment to pregnancy of the patients in the observation group were significantly shorter than those of the patients in the control group. The number of ovulation (1.94±0.46) and dominant follicles (1.68±0.41) of the patients in the observation group were significantly higher than those (1.71±0.49 and 1.43±0.32) of the patients in the control group (all P<0.05). There was no significant difference in the ovulation rate (84.2% vs. 91.5%) of the patients between the two groups (P>0.05). Conclusion: The combination of estradiol valerate, letrozole and progesterone for treating the infertility patients with PCOS can increase their efficacy, improve their endometrial receptivity, enhance their ovarian function, regulate their levels of sex hormones, promote their follicular development and improve their pregnancy outcomes.

To investigate the clinical efficacy of the laparoscopic high ligation of spermatic vein combined with electrophysiology for treating patients with asthenozoospermia caused by varicocele. Methods: 150 patients with asthenozoospermia caused by varicocele were randomly selected and were divided into three groups (50 patients in each group) by randomized numerical table method, including the patients with the laparoscopic high ligation of spermatic vein alone in group A, the patients with the electrophysiology therapy alone in group B and the patients with the laparoscopic high ligation of spermatic vein combined with electrophysiology therapy in group C. The clinical efficacy of the patients was compared among the three groups. Results: In 3 months after treatment, the sperm concentration, the sperm forward motility (PR) and the pain severity score by visual analog scale (VAS) of the patients in the three groups had improved significantly. The sperm concentration (67.86±15.90×106/ml), the PR (55.81±15.69 %) and the VAS score (3.06±0.58 points) of the patients in group C were significantly better those (49.00±20.23×106/ml, 40.83±11.28 % and 4.4±0.59 points) of the patients in group A and those (58.33±19.12 ×106/ml, 48.52±13.72 % and 3.85±0.42 points) of the patients in group B (all P<0.05). The clinical treatment effective rate of the patients in group B (96%) or in group C (98%) was significantly higher than that (78%) of the patients in group A (all P<0.05), and which of the patients in group B had no significantly different from that of the patients in group C (P>0.05). Conclusion: The laparoscopic high ligation of spermatic vein combined with the electrophysiological therapy for the patients with asthenozoospermia caused by varicocele can significantly improve their sperm quality and scrotal pain.

To evaluate the clinical effect of Xia Guicheng regulating cycle method combined with Gexia Zhuyu decoction for treating patients with primary dysmenorrhea of qi stagnation and blood stasis type. Methods: 105 patients with primary dysmenorrhea of qi stagnation and blood stasis type were randomly divided into observation group (50 cases) and control group (55 cases). The patients in the control group were treated with Gexia Zhuyu decoction for 7 days as one course of treatment for 3 courses during their menstruation. On the basis of the treatment of the patients in the control group, the patients in the observation group were treated with menstrual cycle adjustment method additionally. The clinical efficacy of the patients was compared between the two groups. Results: After three menstrual cycles of treatment, the pain score by visual analogue scale (VAS) of the patients in both groups had decreased significantly, and which (1.9±0.5 points) of the patients in the observation group was significantly lower than that (2.9±0.9 points) of the patients in the control group. The dysmenorrhea symptom score of the patients in both groups after treatment had decreased significantly, and which (6.3±2.3 points) of the patients in the observation group was significantly lower than that (10.3±1.7 points) of the patients in the control group. The Cox menstrual symptom scale (CMSS) score of the patients in both groups after treatment had decreased significantly, and the CMSS score (6.8±1.6 points) and the pain duration (11.7±4.1 day) of the patients in the observation group were significantly lower than those (9.4±2.1 points and 26.1±3.2 day) of the patients in the control group. The TCM syndrome score of the patients in both groups after treatment had decreased significantly, and which (5.2±1.4 points) of the patients in the observation group was significantly lower than that (6.6±1.7 points) of the patients in the control group. The values of the pulsatility index (PI) and resistance index (RI) of the uterine artery of the patients after treatment had decreased significantly, and which (1.51±0.1 points and 0.72±0.01 points) of the patients in the observation group were significantly lower than those (2.26±0.05 points and 0.83±0.03 points) of the patients in the control group (all P<0.05). Conclusion: The Xia Guicheng regulating cycle method combined with Gexia Zhuyu decoction for treating the patients with primary dysmenorrhea of qi stagnation and blood stasis type can significantly relieve their clinical symptoms, and which has higher medication safety.

To investigate the influence of the adjuvant therapy with Biqi capsule for patients with endometriosis (EMS) because of Qi-stagnation and blood stasis on their dysmenorrhea and hemorheology. Methods: 106 patients with EMS because of Qi-stagnation and blood stasis were randomly divided into two groups (53 cases in each group) from January 2023 to September 2024. The patients in the two groups received laparoscopic surgery combined with gonadotropin releasing hormone agonist, and the patients in the observation group were given Biqi capsule for 3 months additionally. The clinical efficacy, the TCM syndrome score, the values of hemorheology indexes, such as plasma viscosity, low-shear whole blood viscosity, hematocrit and erythrocyte sedimentation rate, the levels of hormone indexes, such as prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α), follicle stimulating hormone (FSH) and estradiol (E2), the pain duration, the scores of the visual analogue scale (VAS) and short form endometriosis health profile questionnaire (EHP-5) and the adverse reactions rate of the patients in the two groups were observed. Results: After treatment, the total effective rate (96.2%) of the patients in the observation group was significantly higher than that (84.9%) of the patients in the control group, and the TCM syndrome scores of the patients in the observation group were significantly lower than those of the patients in the control group (P<0.05). The plasma viscosity, the whole blood low-shear viscosity, the hematocrit and the erythrocyte sedimentation rate of the patients in the observation group were significantly lower than those of the patients in the control group (P<0.05). The levels of E2, FSH, PGE2 and PGF2αof the patients in the observation group were significantly lower than those of the patients in the control group (P<0.05). The duration of pain (5.37±1.34h), the VAS score (2.08±0.32 points) and the EHP-5 score (1.24±0.43 points) of the patients in the observation group were significantly lower than those (5.92±1.45h, 2.43±0.50 points and 1.69±0.46 points) of the patients in the control group (all P<0.05). There was no significant difference in the incidence of adverse reactions (11.3% vs. 13.2%) of the patients between the two groups (P>0.05). Conclusion: The adjuvant therapy with Biqi capsule for the patients with EMS because of Qi-stagnation and blood stasis can effectively improve their hemorheology index and sex hormones levels, alleviate their severity dysmenorrhea pain, short their duration of dysmenorrhea pain and improve their quality of life.

To explore the correlation between the serum monocyte chemoattractant protein (MCP)-1, Toll-like receptor (TLR) 4 and endothelin (ET) levels of patients with polycystic ovary syndrome (PCOS) and their therapeutic effect of letrozole. Methods: 120 patients with PCOS who underwent letrozole treatment in the hospital from July 2021 to August 2024 were selected as the subjects. All the patients received the routine treatment, and the oral letrozole tablets were given to all of the patients on the 5th day of their menstrual cycle for a total of 3 menstrual cycles. These patients were divided into group A (patients with effectiveness of treatment) and group B (patients without effectiveness of treatment) based on the treatment outcomes. The serum MCP-1, TLR4 and ET levels of the patients in the two groups were detected before treatment and after 3 menstrual cycles of treatment. The general information and the serum MCP-1, TLR4, and ET levels of the patients were compared between the two groups. Multivariate logistic regression was used to analyze the factors affecting the therapeutic effect of letrozole. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the serum MCP-1, TLR4 and ET levels of the patients for the ineffectiveness of letrozole treatment. Results: Among 120 patients with PCOS, there were 94 (78.3%) cases with effective treatment and 26 (21.7%) cases with ineffective treatment. Before treatment, the levels of the serum MCP-1, TLR4 and ET of the patients in group A were significantly lower than those of the patients in group B. After treatment, the levels of the serum MCP-1, TLR4 and ET of the patients in the two groups had decreased significantly, and the decreased degrees of the patients in group A were significantly greater (all P<0.05). Multivariate logistic regression analysis showed that the increased serum MCP-1, TLR4 and ET levels of the patients with PCOS before treatment were the risk factors affecting their therapeutic effect of letrozole (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of the serum MCP-1, TLR4 and ET levels of the patients for predicting their therapeutic effect of letrozole were 0.788, 0.852 and 0.862, respectively. The AUC, the sensitivity and the specificity of the combined serum MCP-1, TLR4 and ET levels of the patients for predicting their therapeutic effect of letrozole were 0.947, 92.3% and 87.2%, respectively, and which were the best. Conclusion: The levels of the serum MCP-1, TLR4 and ET of the patients with PCOS and without response to letrozole before and after the treatment are higher. The increased levels of MCP-1, TLR4 and ET of the patients with PCOS are the risk factors of their ineffective treated byletrozole, and the serum MCP-1, TLR4 and ET levels of the patients for predicting their therapeutic effect of letrozole have certain value and the combined serum MCP-1, TLR4 and ET levels of the patients for their therapeutic effect of letrozole has the best predictive effect. 

To analyze the predictive value of the serum non-high-density lipoprotein cholesterol (non-HDL-C)/HDL-C ratio (NHHR) of pregnant women during the first trimester of their gestational diabetes mellitus (GDM) risk. Methods: 206 pregnant women who were examined in the hospital from January 2023 to January 2024 were collected as the subjects. The general data of these women were collected. The blood lipid levels of these women were detected during 6-12 gestational weeks, and the values of non-HDL-C value and NHHR of these women were calculated. These women were divided into group A (112 women without GDM) and group B (94 women with GDM) according to the occurrence of their GDM during the pregnant follow-up. The influencing factors of GDM occurrence of the pregnant women were explored by multivariate logistic regression. The predictive value of NHHR of the women for their GDM was analyzed by receiver operator characteristic (ROC) curve. Results: The BMI value, the family history of diabetes rate, the levels of FPG, triglyceride and total cholesterol of the women in group B before pregnancy were significantly higher than those of the women in group A, and the HDL-C level of the women in group B was significantly lower. The non-HDL-C level (3.04±0.53 mmol/L) and the NHHR value (1.80±0.26) of the women in group B were significantly higher than those (2.17±0.41 mmol/L and 1.14±0.12) of the women in group A (all P<0.05). Multivariate analysis showed that the high pre-pregnancy BMI value (OR=2.527), the family history of diabetes (OR=1.972), the high FPG level (OR=2.100), the high triglyceride level (OR=2.366), the high non-HDL-C level (OR=3.136) and the high NHHR value (OR=3.522) of the pregnant women were the influencing factors of their GDM occurrence. The area under the curve (0.905) of the NHHR of the pregnant women for predicting their GDM occurrence was significantly higher than that (0.813) of the non-HDL-C level (all P<0.05). Conclusion: The increased serum NHHR of the pregnant women during the first trimester of pregnancy is associated with their occurrence of GDM, and the serum NHHR of the pregnant women during the first trimester of pregnancy can be used as the clinical marker to predict their risk of GDM occurrence.

To investigate the effects of the combined spinal anesthesia and peripheral nerve block used in the cesarean section of pregnant women on their postoperative early cognitive function, emotional response and inflammatory indicators. Methods: A total of 160 pregnant women who wanted cesarean section in the hospital were collected and randomly divided into control group and observation group (80 cases in each group) from May 2023 to December 2024. The women in the control group received the spinal anesthesia during the cesarean section, while the women in the observation group received the combined spinal anesthesia and peripheral nerve block during the cesarean section. The scores of the pain evaluated by visual analogue scale (VAS), the cognitive function evaluated by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) and the emotional response evaluated by Athens insomnia scale (AIS), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) and the levels of the inflammatory indicators, such as the tumor necrosis factor alpha(TNF-α), D-dimer(D-D) and C-reactive protein (CRP), at T0 (during operation), T1 (at 6 postoperative hours), T2 (at 24 hours postoperatively) and T3 (at 48 hours postoperatively), and the postoperative adverse reactions of the women in the two groups were recorded. Results: There was no significant difference in the VAS score of the women at T1 between the two groups (P>0.05). The VAS score of the women in the two groups had decreased gradually, and which of the women in the observation group at T2 and at T3 (2.91±1.41 points and 2.06±1.13 points) were significantly lower than those (3.41±1.43 points and 2.73±1.53 points) of the women in the control group (all P<0.05). The MMSE score of the women in the two groups had increased gradually, and which of the women in the observation group at T1-T3 were significantly higher than those of the women in the control group (all P<0.05). There was no significant difference in the MoCA score of the women at T0 between the two groups (P>0.05). The MoCA score of the women in the two groups at T1-T3 had increased gradually, and which of the women in the observation group was significantly higher than that of the women in the control group (P<0.05). After operation, the scores of AIS, SAS and SDS of the women in the two groups had increased to varying degrees. However, the sores of AIS (5.48±2.77 points), SAS (55.91±7.03 points) and SDS (55.36±8.06 points) of the women in the observation group were significantly lower than those (6.43±2.88 points, 58.63±9.58 points and 59.00±9.47 points) of the women in the control group (all P<0.05). The levels of TNF-α, D-D and CRP of the women at T0 and at T1 had no significant differences between the two groups (P>0.05), and which of the women in the two groups at T2-T3 had decreased gradually, and which of the women in the observation group were significantly lower than those of the women in the control group (all P<0.05). The women in both groups had different degrees of dizziness, nausea and vomiting, respiratory depression and blurred vision, etc. There was no significant difference in the total incidence of the adverse reactions (12.5% vs. 6.3%) of the women between the two groups (P=0.175). Conclusion: The combined spinal anesthesia and peripheral nerve block used in the cesarean section of the pregnant women has the certain advantage in the improvements of the early postoperative cognitive function, emotional response and inflammatory indicators of the women.

To explore the effect of the portable biological stimulation feedback instrument combined with the reverse pressure softening method of the women on their postpartum milk siltation. Methods: A total of 122 women with postpartum milk siltation admitted to the hospital from July 2023 to October 2024 were selected and were divided into two groups according to random number table method from July 2023 to October 2024. 61 women in the two groups were given the routine breastfeeding guidance combined with the breast massage milking or electric pumping, and 61 women in the observation group were given the reverse pressure softening method combined with the portable biological stimulation feedback instrument additionally. The efficacy, the breast distension situation, the breast pain, the lactation volume and the success rate of breastfeeding of the women were compared between the two groups. Results: After 3 days of treatment, the total effective rate (96.7%) of the women in the observation group was significantly higher than that (83.6%) of the women in the control group, and the percentage of the degree of breast distension Ⅰ degree, Ⅱ degree or Ⅲ degree (60.7%, 34.4% or 4.9%) of the women in the observation group was significantly better than that (49.2%, 21.3% or 29.5%) of the women in the control group. The percentages of the breast pain, the mild pain, the moderate pain and the severe pain (9.8%, 49.2%, 37.7% and 3.3%) of the women in the observation group were significantly better than those  (3.3%, 27.9%, 57.4% and 11.5%) of the women in the control group. The amount of milk secretion (671.25±155.31 ml) of the women in the observation group was significantly higher than that (581.39±138.72 ml) of the women in the control group, and the success rate of breastfeeding (93.4%) of the women in the observation group was significantly higher than that (77.1%) of the women in the control group (all P<0.05). Conclusion: The portable biological stimulation feedback instrument combined with the reverse pressure softening method for the women with milk siltation can reduce their postpartum breast tenderness, promote their milk discharge and improve their curative effect.

To explore the effect of the different duration of cook balloon placement of patients after their moderate intrauterine adhesion (IUA) surgery. Methods: 76 patients with IUA who had admitted in the hospital were selected in this study from February 2023 to February 2024. These patients were divided into group A and group B by the double-blind lottery method based on the medical record number of the patients. The cook balloon was placed for the women in both groups after hysteroscopic IUA resection. 38 patients in group B were given the cook balloon placement for 7 days after IUA surgery, and 38 patients in group A were given the cook balloon placement for 30 days after IUA surgery. The score of American fertility society uterine adhesion (AFS), the uterine artery flow spectrum, the endometrial thickness and the complication rate of the patients were compared between the two groups. Results: The AFS score (1.17±0.08 points) of the patients in group A was significantly lower than that (1.79±0.25 points) of the patients in group B (P<0.05). The flow resistance index (RI) and the uterine artery pulsation index (PI) of the patients in group A were 0.51±0.09 and 1.38±0.25, and which were significantly lower than those (0.78±0.16 and 1.85±0.43) of the patients in group B. The endometrial thickness (8.59±1.24) of the patients in group A was significantly higher than that (7.21±0.86) of the patients in group B (P<0.05). There were 2 cases with reproductive tract infection and 2 cases with abnormal uterine bleeding in group A. In group B, there was 1 case with postoperative massive hemorrhage. Conclusion: The postoperative cook balloon placement for 30d of the patients with moderate IUA surgery has better effect than that of the postoperative cook balloon placement for 7d.

To explore the application effect of the diversified nursing based on Roy adaptive model for women with hypertension disease of pregnancy (HDP) and postpartum hemorrhage in intensive care unit (ICU). Methods: 149 women with HDP and postpartum hemorrhage who admitted to the ICU of the hospital from March 2022 to March 2024 were divided into two groups by random number table method. 75 women in the control group were given the routine ICU care and 74 women in the observation group were given the diversified nursing based on Roy adaptive model. The hemostatic effect, the coagulation function, the negative emotion score, the nursing satisfaction and the health economics indicators of the women were compared between the two groups. Results: The blood loss of the women in the observation group in 12 h (150.1±15.4ml) or in 24 h (111.2±14.6ml) after nursing was significantly less than that (261.2±18.1ml or 167.1±15.4ml) of the women in the control group. The hemoglobin (Hb, 110.98±13.45g/L) of the women in the observation group at 24 hours after nursing was significantly higher than that (89.34 ±11.21g/L) of the women in the control group. The hemostasis time (2.67±0.56d) of the women in the observation group was significantly shorter than that (4.24±1.11d) of the women in the control group (all P<0.05). There were no significant differences in the values of the serum fibrinogen, prothrombin time and activated partial thromboplastin time of the women between the two groups (P>0.05). The scores of anxiety (40.28±7.12 points) and depression self-rating scale (44.09±6.21 points) of the women in the observation group were significantly lower than those (48.99±5.11 points and 47.26±7.55 points) of the women in the control group, and the nursing satisfaction (94.6%) of the women the observation group was significantly higher than that (84.0%) of the women in the control group. The health economic index (2532.49±67.34 yuan/d) of the women in the observation group was significantly better than that (2570.02±88.21 yuan/d) of the women in the control group (all P<0.05). Conclusion: The diversified care based on Roy adaptation model was given to the women with HDP and postpartum hemorrhage in ICU can reduce their bleeding, shorten their hemostasis time and ICU stay time, reduce their psychological burden, and improve their nursing satisfaction and health economics indicators.

To explore the application effect of the hierachy of needs nursing in improving the cancer-related fatigue of patients with ovarian cancer. Methods: From August 2022 to January 2024, a total of 96 patients with ovarian cancer treated in the hospital were divided into two groups (48 cases in each group) by random number table method. The patients in the two groups were given the routine nursing for 3 months, and the patients in the observation group were given the hierachy of needs nursing additionally. The improvement situation of the cancer-related fatigue symptoms of the patients in the two groups before and after intervention was observed. The changes of mental resilience, coping style and quality of life of the patients were compared between the two groups. Results: After 3 months of intervention, the scores of the all dimensions of CD-RISC of the patients in the observation group were significantly higher than those of the patients in the control group, and the scores of the all dimensions of the revised Piper fatigue scale of the patients in the observation group were significantly lower than those of the patients in the control group. The positive coping factor score of the coping style rating scale (27.01±2.23 points) of the patients in the observation group was significantly higher than that (25.67±2.17 points) of the patients in the control group. The negative coping factor score (18.33±3.15 points) of the patients in the observation group was significantly lower than that (20.17±3.01 points) of the patients in the control group, and the scores of psychological function (46.17±4.03 points) and physical function (28.08±2.39 points) of the quality of life measurement scale of the patients in the observation group were significantly higher than those (43.08±4.45 points and 26.19±2.81 points) of the patients in the control group. The adverse reaction score (21.11±2.37 points) of the patients in the observation group was significantly lower than that (22.14±2.15 points) of the patients in the control group (all P<0.05). Conclusion: The hierachy of needs nursing for the patients with ovarian cancer can enhance their mental resilience, improve their cancer-related fatigue symptoms and help to positively change their disease coping style and improve their overall quality of life.

To explore the effects of the group psychological intervention based on ADOPT model for obese patients with polycystic ovary syndrome (PCOS) on their weight management and quality of life. Methods: In a prospective study, a total of 110 obese patients with PCOS admitted to the hospital from October 2023 to October 2024 were included and were divided into two groups (55 cases in each group). The patients in the two groups were given the routine nursing intervention, and the patients in the observation group were given the group psychological intervention based on ADOPT model additionally. The changes of the relevant indicators of weight loss effect of the patients before and after the intervention were compared between the two groups. Self-rating anxiety scale (SAS), self-rating depression scale (SDS) and 36-item short-term health survey scale (SF-36) were used to evaluate the anxiety, the depression and quality of life of the patients in the two groups before and after intervention. The changes of the follicle development, the endometrial indictors, and the levels of the reproductive hormone indexes, such as testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH), before and after intervention, the health knowledge awareness rate, the ovulation success rate and intervention satisfaction rate of the patients were compared between the two groups. Results: After the intervention, the waist-hip ratio, the body fat rate, the body mass index, the scores of SAS and SDS, the T and LH levels of the patients in the two groups had decreased significantly, and the number of follicles of the patients in the two groups had reduced significantly, and the changes of which of the patients in the observation group were significantly better than those of the patients in the control group. The SF-36 score, FSH level and the endometrial thickness of the patients in the two groups had increased significantly, and the improvement degree of which of the patients in the observation group were significantly better than those of the patients in the control group. The success rate of ovulation (90.9%), the awareness rate of health knowledge (96.4%) and the satisfaction rate of intervention (94.6%) of the patients in the observation group were significantly higher than those (72.7%, 85.4% and 81.8%) of the patients in the control group (all P<0.05). Conclusion: The group psychological intervention based on ADOPT model for the obese patients with PCOS can help them better manage their weight, improve their obese and psychological status, and their quality of life and reproduction indicators, improve their disease knowledge awareness rate and intervention satisfaction rate. However, the effects of the group psychological intervention for the patients on their pregnancy outcomes still needs to be further discussed. 

To investigate the effects of SHEL mode based on the team resource management for women with caesarean section caused by dangerous placenta previa on their adverse events, postpartum recovery and quality of nursing. Methods: 149 women with caesarean section caused by dangerous placenta previa in the hospital from January 2022 to December 2023 were divided into two groups. 67 women in group A from January 2022 to December 2022 were given the traditional nursing mode and 82 women in group B from January 2023 to December 2023 were given the SHEL nursing mode based on the team resource management. The perioperative indicators, the changes of the intraoperative signs, the incidence of the intraoperative adverse events and the postoperative complications rate of the women in the two groups were observed. The quality of nursing of the women in the two groups was evaluated. Results: The preoperative preparation time, the postoperative blood loss and the operation time of the women in group B were significantly shorter than those of the women in group A, and the neonatal Apgar scores at 1 min and at 5 min after birth in group B were significantly higher than those in group A (all P<0.05). There was no significant difference in the hospitalization time of the women between the two groups (P>0.05). The values of body temperature, systolic blood pressure and diastolic blood pressure of the women in group B at the time of fetal delivery and at placental separation were significantly higher than those of the women in group A, and the heart rate of the women in group B was significantly lower. The total incidence of the adverse events (2.4%) of the women in group B was significantly lower than that (23.9%) of the women in group A, including the intraoperative massive bleeding, the intraoperative hypothermia, the medical equipment failure, the medical equipment alarm response error, the surgical materials inventory error and the un-prepared rescue medicine. The total incidence of the postoperative complications (7.3%) of the women in group B was significantly lower than that (23.9%) of the women in group A, and the scores of the each dimension of nursing quality of the women in group B were significantly higher than those of the women in group A (all P<0.05). Conclusion: SHEL mode of nursing management based on the team resource management for women with caesarean section caused by dangerous placenta previa can effectively shorten their preoperative preparation time and operation time of cesarean section, reduce their amount of bleeding during operation, improve their quality of fetal delivery, reduce their incidence of intraoperative adverse events and intraoperative complications rate, and with the high overall quality of nursing.

To observe the effect of the empathy-based dyadic intervention for the couples of patients with the laparoscopic surgery of ectopic pregnancy. Methods: 82 patients who underwent laparoscopic surgery of ectopic pregnancy from March 2022 to May 2024 were enrolled and were randomly divided into observation and control groups by the random number table. 41 patients in the two groups received the routine nursing care, while 41 patients in the observation group received the additional empathy-based dyadic intervention for the couples. The self-disclosure level evaluated by distress disclosure index (DDI) score, the marital intimacy evaluated by marital adjustment test (MAT) score, the negative emotions evaluated by self-rating anxiety scale (SAS) score and self-rating depression scale (SDS) score, the dyadic coping evaluated by dyadic coping inventory (DCI) score, the postoperative recovery and the quality of life evaluated by short form-36 health survey (SF-36) score of the patients were compared between the two groups. Results: After intervention, the scores of DDI (48.65±5.21 points), MAT (106.78±8.55 points), DCI of the patients and their spouses (112.36±8.52 points and 128.74±8.15 points) and SF-36 of the patients in the observation group were significantly higher than those (40.45±4.53 points, 81.65±6.74 points, and 96.51±7.84 points and 117.28±7.42 points) of the patients in the control group. The scores of SDS (45.51±4.28 points) and SAS (41.64±4.36 points) of the patients in the observation group were significantly lower than those (50.45±4.16 points and 48.71±4.29 points) of the patients in the control group. The time of firstly getting out of bed, the first defecation, the first exhaust and the postoperative hospital stay of the patients in the observation group were significantly shorter than those of the patients in the control group (all P<0.05). Conclusion: The implementation of the empathy-based dyadic intervention for the patients with the laparoscopic surgery of ectopic pregnancy can improve their self-disclosure level, enhance their marital intimacy, reduce their negative emotions, increase their dyadic coping level, promote their postoperative recovery and improve their quality of life.

To explore the impact of the rehabilitation nursing based on failure mode and effects analysis (FMEA) model for patients with ovarian cyst surgery on their postoperative complications and rehabilitation progress. Methods: 89 patients who underwent laparoscopic ovarian cystectomy surgery from January 2023 to June 2024 were selected as the study subjects. According to the random number table method, these patients were divided into control group (n=44) and experimental group (n=45). The patients in the control group received the routine postoperative care, while the patients in the experimental group received the postoperative care of FMEA model. The postoperative rehabilitation indicators and the incidence of complications of the patients were compared between two groups. Results: The first time of getting out of bed (10.53±1.86 hours), the first anal exhaust time (14.63±3.25 hours), the first defecation time (30.47±6.19 hours) and the hospitalization time (6.63±1.25 days) of the patients in the experimental group after surgery were all significantly lower than those (14.92±2.95 h, 16.85±4.15 h, 39.84±5.63  and 10.53±2.64 d) of the patients in the control group (P<0.05). In three months after the intervention, the scores of psychological domain (13.01±2.12 points), physiological domain (15.02 ± 2.14 points) and overall sensation (12.64±2.51 points) of the patients in the experimental group were significantly higher than those (11.89±2.42 points, 13.54±2.56 points and 10.94±2.84 points) of the patients in the control group (P<0.05). There were no statistically significant differences in the scores of the environmental domain (13.22±2.37 points vs. 13.35±2.53 points) and the social relations domain (13.16±2.53 points vs. 13.54±2.14 points) of the patients between the two groups (P>0.05). The total incidence of complications (11.1%) of the patients in the experimental group was significantly lower than that (36.4%) of the patients in the control group. The overall satisfaction rate (97.8%) of the patients in the experimental group was significantly higher than that (81.8%) of the patients in the control group (all P<0.05). Conclusion: The rehabilitation nursing based on FMEA model for the patients with ovarian cyst surgery can enhance their recovery, reduce their incidence of postoperative complications and improve their nursing satisfaction. 

To observe the influence of the developmental care model intervention based on Home concept for children with neonatal pneumonia on their prognosis. Methods: 80 children with neonatal pneumonia in the hospital were selected and were divided into group A (40 cases with the routine nursing intervention) and group B (40 cases with the developmental care model intervention based on Home concept combined with the routine nursing intervention) by random envelope method from June 2023 to December 2024. After 4 days of intervention, the hospitalization time, the physiological indicators, the respiratory rate (RR), the  blood oxygen saturation (SpO2), the daily sleep time, the daily milk intake, the feeding intolerance situation and the psychological status of the family members evaluated by Beck anxiety inventory (BAI) of the children were compared between the two groups. Results: The hospitalization time (6.40±0.78d) of the children in group B was significantly shorter than that (8.63±2.24d) of the children in group A. After 2 days and 4 days of intervention, the RR level and the BAI score of the family members of the children in the two groups had decreased gradually, and which of the children in group B were significantly lower than those of the children in group A. The SpO2 value of the children in the two groups had increased gradually, and which of the children in group B was significantly higher than that of the children in group A. The daily sleep time and the daily feeding volume of the children in the two groups had increased gradually, and which of the children in group B were significantly higher than those of the children in group A. The incidence of feeding intolerance (2.5%) of the children in group B was significantly lower than that (20.0%) of the children in group A (all P<0.05). Conclusion: The developmental care model based on Home concept for the children with neonatal pneumonia can shorten their hospitalization time, regulate their respiratory status, improve their sleep and nutritional status, reduce the occurrence of their feeding intolerance, and alleviate the negative emotions of their family members, and which has the clinical application value.

To explore the influence of the etomidate combined with the midazolam for anesthesia induction during laparoscopic surgery of the ectopic pregnancy of patients on their anesthesia effect, hemodynamics and stress response. Methods: According to the simple randomized grouping method, 110 patients who wanted laparoscopic surgery of the ectopic pregnancy in the hospital were divided into observation group and control group (55 cases in each group) from October 2021 to October 2023. The patients in the control group received the propofol combined with the midazolam for anesthesia induction, while the patients in the observation group adopted the etomidate combined with the midazolam for anesthesia induction. The anesthesia effect, the adverse reactions, and values of the hemodynamics indicators, such as the mean arterial pressure (MAP) and heart rate (HR), the levels of the stress response indicators, such as the cortisol (Cor) and norepinephrine (NE), and the cerebral oxygen supply-demand balance indicators, such as the cerebral oxygen saturation (ScO2) and bispectraldex (BIS) before anesthesia (T0), during induction (T1), at 10 min after maintenance (T2) and at the end of surgery (T3) of the patients were compared between the two groups. Results: The onset time of the anesthesia (1.01±0.26 min), the recovery time (7.07±1.56 min), the recovery time of spontaneous breathing (5.34±1.01 min) of the patients in the observation group were significantly lower than those (1.29±0.29 min, 9.89±2.34 min and 7.25±1.19 min) of the patients in the control group. There was no significant difference in the total incidence of the adverse reactions (7.2% vs. 10.8%) of the patients between the two groups (P>0.05). There were no significant differences in the values of MAP, HR, Cor, NE, ScO2 and BIS of the patients at T0 between the two groups (P>0.05). At T1, T2 and T3, the values of MAP and HR, and the levels of Cor and NE of the patients in the observation group were significantly lower than those of the patients in the control group, and the ScO2 value of the patients in the observation group was significantly higher than that of the patients in the control group (all P<0.05), but there was no significant difference in the BIS value of the patients between the two groups (P>0.05). Conclusion: The etomidate combined with the midazolam for anesthesia induction during the laparoscopic surgery of the ectopic pregnancy of the patients can enhance their anesthesia effect, and which also has the positive impact on the hemodynamics and cerebral oxygen supply-demand balance of the patients, and can relieve the surgical stress response and reduce the incidence of the adverse reactions of the patients.

To analyze the application effect of the optimized feeding strategy based on evidence-based practice theory in the feeding intervention of premature infants. Methods: 90 premature infants who born and treated in the hospital from July 2021 to July 2024 were selected and were divided into control group (45 infants with the standardized neonatal feeding strategy intervention) and study group (45 infants with the optimized feeding strategy intervention under evidence-based practice theory) by the random number table method. The breastfeeding rate, the feeding performance and the physical development of the infants at discharge were compared between the two groups. The relevant outcome indicators during hospitalization and the family nursing satisfaction of the infants were compared between the two groups. Results: At discharge, the breastfeeding rate (73.3%), the sucking milk velocity (5.03±0.95 ml/min) and the sucking milk volume (47.55±8.28 ml/time) of the infants in the study group were significantly higher than those (51.1%, 4.57±0.88 ml/min and 42.29±7.64 ml/time) of the infants in the control group. The weight (3.11±0.52 kg), the head circumference (36.19±1.47 cm) and the length (49.63±2.85 cm) of the infants in the study group were significantly higher than those (2.85±0.49 kg, 35.35±1.38 cm and 47.02±2.31 cm) of the infants in the control group. During the hospitalization, the incidence of the feeding intolerance (4.4%) of the infants in the study group was significantly lower than that (17.8%) of the infants in the control group, and the time to the complete oral feeding (2.54±0.91d) and the duration of hospital stay (11.55±2.32d) of the infants in the study group were significantly shorter than those (5.73±1.17d and 14.38±2.89d) of the infants in the control group. The total nursing satisfaction (100.0%) of the family members in the study group was significantly higher than that (91.1%) in the control group (P<0.05). Conclusion: The optimized feeding strategy based on evidence-based practice theory in the feeding intervention of the premature infants can effectively improve their breastfeeding rate and feeding performance, reduce the incidence of their FI, and promote their physical development, and which has the higher nursing satisfaction of the family members of the infants, so it is worth promoting and application. 

To explore the effects of the hierarchical management combined with Satya communication model for pregnant women with gestational diabetes mellitus (GDM) on their psychological and delivery outcomes. Methods: A total of 102 pregnant women with GDM were included and were divided into two groups (51 cases in each group) by random number table method from January 2023 to December 2023 group. The women in the control group were given the routine nursing and the women in the observation group were given the routine nursing intervention and the hierarchical management combined with Satya communication mode. The scores changes of Connor-Davidson resilience scale (CD-RISC) and diabetes self-efficacy scale (DSES) before and after intervention, the delivery mode and the maternal and neonatal adverse outcomes rate of the women were compared between the two groups. After intervention, the CD-RISC and DSES scores of the women in the two groups had increased significantly, and which of the women in the observation group were significantly higher than those of the women in the control group. The cesarean section rate (21.6%) of the women in the observation group was significantly lower than that (41.2%) of the women in the control group. The natural delivery rate (78.4%) of the women in the observation group was significantly higher than that (54.0%) of the women in the control group. The adverse outcomes of delivery (2.0%) and the neonatal adverse outcomes (9.8%) of the women in the observation group were significantly lower than those (13.7% and 27.5%) of the women in the control group (all P<0.05). Conclusion: The hierarchical management combined with the Satya communication mode for the pregnant women with GDM can better improve their psychological state and mental resilience, increase their self-efficiency, and which is help to their natural delivery and to decrease their delivery adverse outcomes and their neonatal adverse outcomes. 

To investigate the impact of the nursing team strategy-based pain intervention combined with focused psychological counseling for patients with ovarian cysts surgery on their postoperative pain, emotions and sleep quality. Methods: A total of 120 patients with ovarian cysts surgery in the hospital from January 2024 to January 2025 were collected retrospectively. Among them, 60 cases from January 2024 to July 2024 were included in the control group, and 60 cases from August 2024 to January 2025 were included in the observation group. The patients in the control group received the routine nursing care, while the patients in the observation group received the nursing team strategy-based pain intervention combined with focused psychological counseling. The scores of postoperative pain numeric rating scale (NRS), self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Pittsburgh sleep quality index (PSQI), and the adverse reactions rate of the patients after surgery were compared between the two groups. Results: The NRS score of the patients in the two groups at 24 hours after surgery was significantly higher than that of the patients before surgery. The scores NRS, SAS, SDS and PSQI, and the proportions of anxiety and depression of the patients in the two groups at 48-72 hours after surgery were significantly lower than those of the patients. However, the scores of NRS (2.13±1.00 points and 1.82±0.79 points), SAS (41.62±6.27 points) and the SDS (42.53±7.55 points) and PSQI (11.68±2.32 points), and the proportion of anxiety (8.3%) of the patients in the observation group at 48 hours and at 72 hours after surgery were significantly lower than those (2.63±1.41 points, 2.63±1.10 points, 46.08±5.14 points, 46.12±5.65 points,13.78±2.39 points, and 21.7%) of the patients in the control group (all P<0.05). There was no significant difference in the incidence of postoperative adverse reactions (6.7% vs. 11.7%) of the patients between the two groups (P>0.05). Conclusion: The nursing team strategy-based pain intervention combined with focused psychological counseling for the patients with ovarian cysts surgery helps to improve their postoperative pain, emotions and sleep quality.

To construct a postoperative social support system for the cesarean section of parturients, to intervene by the social support system and to evaluate the effects of this system on the physiological recovery, the emotional state, the sleep quality, the self-identity and the role adaptation of the parturients after 6 weeks of cesarean section. Methods: A total of 144 parturients who underwent cesarean section in the hospital from October 2023 to November 2024 were selected as the research objects. According to the operation time, these parturients were divided into two groups, including 75 parturients who underwent cesarean section from October 2023 to April 2024 were included in the control group, and 69 parturients who underwent cesarean section from May to November 2024 were included in the intervention group. The parturients in the two groups received the routine postoperative treatment and intervention care measures, and the parturients in the intervention group were given the intervention by the constructed the social support system according to their condition and evaluated after cesarean section additionally. The physiological, the emotional, the sleep quality, the self-identity and the role adaptation of the parturients after 6 weeks of the cesarean section were compared between the two groups. Results: After 6 weeks of cesarean section, the good rates of the uterine size involution (94.2%) and the endometrial repair (92.8%) of the parturients in the intervention group were significantly better than those (82.7% and 81.3%) of the parturients in the control group. The score of Edinburgh postnatal depression scale ［10.0(7.0, 12.0) points］, General anxiety scale ［7.0(5.0, 12.0) points］ and Pittsburgh sleep quality index ［7.00(5.50, 9.00) points］ of the parturients in the intervention group were significantly lower than those ［10.0(9.0, 13.0) points, 8.0(7.0, 9.0) points and 9.0(7.0, 12.0) points］ of the parturients in the control group. The scores of the all dimensions of the maternal role adaptation questionnaire of the parturients in the intervention group were significantly higher than those of the parturients in the control group (all P<0.05). Conclusion: The social support system for intervening the parturients has the multi-dimensional improvement effect on their physiological, psychological and social adaptation after 6 weeks of cesarean section, and which can promote the overall recovery of the parturients. 

To evaluate the effects of the knowledge-attitude-practice nursing intervention combined with the peer support for pregnant women with pregnancy-induced hypertension (PIH) on their blood pressure, pregnancy pressure and pregnancy outcomes. Methods: A total of 97 pregnant women with PIH who were examined and delivered in the obstetrics department of the hospital were selected and divided into control group (52 cases) and intervention group (45 cases) according to the random number table method from September 2022 to August 2024. The women in the two groups were given the routine nursing, while the women in the intervention group were given the knowledge-attitude-practice nursing intervention combined with the peer support nursing intervention additionally. The blood pressure, pregnancy pressure and pregnancy outcomes of the women before and after intervention were compared between the two groups. Results: After the intervention, the values of systolic blood pressure and diastolic blood pressure of the women in the two groups had decreased significantly, and which (136.9±4.7 mmHg and 86.0 (83.0, 88.5) mmHg) of the women in the intervention group were significantly lower than those (139.5±6.4 mmHg and 89.0 (84.0, 90.0) mmHg) of the women in the control group. The pregnancy pressure of the women in the two groups had decreased significantly. The pregnancy stress scores from the parental role (18.60±4.05 points) and from the health and safety of the maternal and child (5.00 (4.00, 7.00) points) of the women in the intervention group were significantly lower than those (20.54±4.88 points and 7.00 (6.00, 9.00) points) of the women in the control group. The proportions of the pregnancy termination before 34 gestational weeks (15.6%), the cesarean section (53.3%), the eclampsia (0) and the neonatal Apger score <8 points (4.4%) of the women in the intervention group were significantly lower than those (34.6%, 73.1%, 9.6% and 17.3%) of the women in the control group (all P<0.05). Conclusion: The nursing intervention method of the knowledge-attitude-practice intervention combined with the peer support for the pregnant women with PIH can further reduce their blood pressure value, relieve their pregnancy pressure and reduce their adverse pregnancy outcomes.

To explore the pre-pregnancy thyroid function of pregnant women with recurrent pregnancy loss and the correlation to the levels of thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) of the women and their pregnancy outcomes. Methods: The clinical data of 80 pregnant women with recurrent pregnancy loss who were treated by abortion in the hospital from October 2022 to October 2024 and followed up to obtain the pregnancy outcomes after re-pregnancy were analyzed retrospectively. According to the delivery status of these women, they were divided into group A (women with successful delivery) and group B (women with failed delivery). The levels differences of the serum thyroid function, such as serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4), and TGAb and TPOAb of the women before pregnancy were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the predictive efficiency of the pre-pregnancy TSH, FT3, FT4, TGAb and TPOAb levels of the women with recurrent pregnancy loss on their delivery outcomes. The correlation between the pre-pregnancy TSH, FT3, FT4, TGAb, TPOAb levels of the pregnant women with repeated pregnancy loss and their neonatal Apgar score was analyzed by Pearson correlation coefficient analysis. Results: There were 60 (75.0%) women in group A and 20 (25.0%) women in group B. The levels of the serum TSH, TGAb and TPOAb of the women in group A were significantly lower than those of the women in group B, and the levels of FT3 and FT4 of the women in group A were significantly higher than those of the women in group B (all P<0.05). ROC analysis showed that the area under the curve (AUC) of TSH, FT3, FT4, TGAb and TPOAb levels of the women before pregnancy for predicting their success delivery were 0.750, 0.804, 0.670, 0.792 and 0.812, respectively. In group A, the TSH, TGAb and TPOAb levels of the women with preterm were significantly higher than those of the women without preterm, and the FT3 and FT4 levels of the women with preterm were significantly lower (all P<0.05). ROC analysis showed that the AUC of the TSH, FT3, FT4, TGAb and TPOAb levels of the women before pregnancy to predict their preterm birth were 0.695, 0.786, 0.801, 0.818 and 0.881, respectively. Pearson correlation coefficient analysis showed that the TSH, TGAb and TPOAb levels of the women with repeated pregnancy loss were negatively correlated with their neonatal Apgar score, and the FT3 and FT4 levels of the women with repeated pregnancy loss were positively correlated with their neonatal Apgar score (all P<0.05). Conclusion: The pre-pregnancy thyroid dysfunction of the pregnant women with repeated pregnancy loss is abnormal, and the positive TGAb and TPOAb of the women are significantly associated with their adverse pregnancy outcomes of the repregnancy. 

To analyze the correlation between the levels of blood lipid related indexes of women and their occurrence and development of multiple uterine fibroids. Methods: The clinical data of 86 women with uterine fibroids in the observation group and 60 healthy women who received physical examination in control group from July 2021 to June 2023 collected retrospectively. The levels of the blood lipid related indexes of the women were compared between the two groups. The correlation between the blood lipid related indexes levels of the women and their multiple uterine fibroids was analyzed. The diagnostic value of the blood lipid related indexes levels of the women for their multiple uterine fibroids was analyzed by receiver operating characteristic (ROC) curve. The blood lipid related indexes levels were compared among the women with the different disease severities of uterine fibroids. Results: The levels of the triglyceride (TG, 1.75±0.24 mmol/L), the total cholesterol (TC, 5.42±0.74 mmol/L) and the low density lipoprotein cholesterol (LDL-C, 3.19±0.45mmol/L) of the women in the observation group were significantly higher than those (1.23±0.21 mmol/L, 4.15±0.76 mmol/L and 2.34±0.36mmol/L) of the women in the control group, and which of the women with multiple uterine fibroids were significantly higher than those of the women with single uterine fibroids (all P<0.05). Multivariate logistic analysis showed that the increased TG, TC and LDL-C levels of the women were the risk factors of their multiple uterine fibroids (OR=4.367, 7.675 and 11.894, all P<0.05). The areas under the curve of the levels of TG, TC and LDL-C of the women for diagnosing their multiple uterine fibroids were all >0.70, all of which had the clinical values. In the observation group, the levels of TG, TC and LDL-C of the women with mild uterine fibroids, of the women with moderate uterine fibroids group and of the women with severe uterine fibroids had increased gradually (all P<0.05). Conclusion: The increased levels of TG, TC and LDL-C of the women have certain correlation with the occurrence and development of their multiple uterine fibroids, and which have some diagnostic values for the multiple uterine fibroids of the women. 

To investigate the predictive values of the blood flow parameters by color Doppler ultrasound combined with the maternal serological indexes levels of pregnant women for their fetal growth restriction (FGR). Methods: 72 pregnant women with FGR in the hospital from February 2022 to May 2024 were collected in group A retrospectively, and 72 normal pregnant women during the same period were selected in group B. The general data, the values of the blood flow parameters by color Doppler ultrasound during the 13-20+6 gestational weeks, such as the umbilical artery pulsatility index (PI), the ratio of systolic maximum blood velocity and end-diastolic blood velocity (S/D), the resistance index (RI), the uterine artery RI, the uterine artery PI and the uterine artery S/D, the MOM values of the maternal serological indexes during the 13-20+6 gestational weeks, such as the pregnancy-associated plasma protein A (PAPP-A), the alpha-fetoprotein (AFP) and the placental growth factor (PLGF), of the women in the two groups were collected . Logistic regression was used to analyze the factors affecting the FGR occurrence of the pregnant women. Receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of the blood flow parameters by color Doppler ultrasound and the maternal serological indexes levels for their FGR occurrence. Results: The values of umbilical artery RI, PI, S/D, and the MOM value of AFP of the women in group A were significantly higher than those of the women in group B. The MOM values of PAPP-A and PLGF of the women in group A were significantly lower than those of the women in group B (all P<0.05). Logistic regression analysis showed that the increased values of S/D, RI, PI of umbilical artery and uterine artery, and the increased MOM values PAPP-A, AFP and PLGF of the pregnant women were the influencing factors of their FGR occurrence (P<0.05). The values of S/D, RI, PI of umbilical artery and uterine artery, and the MOM values PAPP-A, AFP and PLGF of the pregnant women had certain values for predicting their FGR occurrence, and the combined detections of which of the women had the highest efficacy for predicting the FGR occurrence of the women (AUC=0.994). Conclusion: The combined detections of the values of S/D, RI, PI of the umbilical artery and uterine artery, and the MOM values PAPP-A, AFP and PLGF of the pregnant women for predicting their FGR occurrence has higher efficacy, and which can be used for the early prevention and management of FGR in clinic. 

To analyze the correlation between the umbilical artery parameters of fetuses by ultrasound and the severity of the fetal hypoxia in their intrauterine distress, and to study their predictive values for the fetal hypoxia in their intrauterine distress. Methods: A retrospective analysis was conducted on the clinical data of 96 pregnant women with intrauterine fetal distress (in observation group) and the data of 100 normal pregnant women (in control group). All the women in the two groups had given birth in the hospital from June 2020 to June 2024. These women in the two groups underwent the umbilical artery ultrasound examinations during pregnancy to obtain the values of resistance index (RI), pulsatility index (PI), maximum end-systolic velocity (S) and maximum end-diastolic velocity (D), and the S/D of the women was calculated. The parameters values of the women by ultrasound were compared between the two groups. The differences and the correlation of the parameter values by ultrasound of the women with the different degrees of intrauterine fetal distress were analyzed. The predictive values of the parameter values by ultrasound of the women for the severity of their intrauterine fetal distress were evaluated by receiver operating characteristic (ROC) curve. Results: The values of RI (0.68±0.19), PI (1.33±0.41) and S/D (3.28±0.94) of the women in the observation group were significantly higher than those (0.52±0.14, 0.93±0.27 and 2.75±0.80) of the women in the control group (P<0.05). After diagnosis, 32 (33.3%) women with the severe intrauterine fetal distress were included in group A and 64 (66.7%) women with the mild to moderate intrauterine fetal distress were included in group B. The values of RI (0.82±0.24), PI (1.49±0.28) and S/D (3.86±0.95) of the women in group A were significantly higher than those (0.61±0.18, 1.25±0.25 and 2.99±0.59) of the women in group B (all P<0.05). ROC analysis showed that the area under the curve (AUC) of the values of RI, S/D and PI of the women for predicting their severe intrauterine fetal distress were 0.734, 0.774 and 0.704, respectively. The AUC (0.894) of the combination of the values of RI, S/D and PI of the women for predicting their severe intrauterine distress was significantly higher than that of the RI value, the PI value or the S/D value alone (all P<0.05). Conclusion: The RI and S/D values of the pregnant women with intrauterine fetal distress are increased, and their PI value is decreased. The RI, PI and S/D values of the pregnant women were correlated with the severity of their intrauterine fetal distress, and which can be used for evaluating the severity of the intrauterine fetal distress of the women. 

To explore the correlation between the levels of the serum vitamin A, vitamin D and vitamin E of pregnant women and their hypertensive disorders of pregnancy (HDP) occurrence. Methods: The clinical data of 481 pregnant women in the hospital from December 2020 to September 2022were selected in this study. Among them, 111 pregnant women with HDP were in study group and 370 healthy pregnant women were in control group. Mass spectrometry was used to measure the levels of the serum vitamin A, vitamin D, and vitamin E of the women in the two groups. Wilcoxon rank sum test was used to analyze the differences of the women between the two groups. Multivariate logistic regression was used to analyze the correlation of the vitamin levels of the pregnant women and their HDP occurrence. Results: The levels of vitamin A (354.60±102.04 ng/ml) and vitamin D (32.15 ±14.66 ng/ml) of the women in the study group were significantly lower than those (383.10±94.91 ng/ml and 37.20 ±13.61 ng/ml) of the women in the control group (all P<0.05). There was no significant difference in the vitamin D level (13.71 ±4.44 mg/L vs. 13.56 ±3.97 mg/L) of the women between the two groups (P>0.05). Multivariate logistic regression analysis showed that the high levels of serum vitamin A and vitamin D of the pregnant women were negatively correlated with their HDP occurrence (P<0.05). Conclusion: The levels of the serum vitamin A and vitamin D of the pregnant women with HDP are decreased, and the vitamin A and vitamin D of the pregnant women should be monitored and supplemented appropriately during their pregnancy.

To explore the values of the serum complement C1q tumor necrosis factor-related protein 5 (CTRP5) and heat shock protein 70 (HSP70) levels of pregnant women with preeclampsia (PE) for predicting their adverse pregnancy outcomes. Methods: The clinical data of 180 pregnant women with PE (in study group) and 150 healthy pregnant women (in control group) from February 2021 to February 2024 were collected. According to the pregnancy outcomes of 180 women in the study group, the women were divided into group A (108 women with normal pregnancy outcomes) and group B (72 women with adverse pregnancy outcomes). The levels of the serum CTRP5 and HSP70 of the women were compared among these groups. The predictive values of the CTRP5 and HSP70 levels of the women with PE for their adverse pregnancy outcomes were evaluated by receiver operator characteristic (ROC) curve, and the influencing factors of the adverse pregnancy outcomes of the women with PE were explored by multivariate logistic regression analysis. Results: The levels of the serum CTRP5 (142.85±15.71 ng/ml) and HSP70 (2.96±0.83 ng/ml) of the women in the study group were significantly higher than those (103.29±10.34 ng/ml and 0.87±0.22 ng/ml) of the women in the control group. The serum CTRP5 and HSP70 levels and the proportions of the early-onset PE and the severe PE of the women in group B were significantly higher than those of the women in group A (all P<0.05). The area under the curve (AUC) of the serum CTRP5 level, the serum HSP70 level and the combination of the serum CTRP5 and HSP70 levels of the women with PE for predicting their adverse pregnancy outcomes were 0.819, 0.772 and 0.926, respectively, and the AUC of combination of the serum CTRP5 and HSP70 levels of the women with PE for predicting their adverse pregnancy outcomes was significantly higher than that of the serum CTRP5 level or the serum HSP70 level alone (P<0.05). Multivariate analysis showed that the early-onset PE, the severe PE, and the increased serum CTRP5 and HSP70 levels of the women with PE were the risk factors of their adverse pregnancy outcomes (all P<0.05). Conclusion: The serum CTRP5 and HSP70 levels of the women with PE are increased, and which were the risk factors of the adverse pregnancy outcomes of the women. The combined detections of the serum CTRP5 and HSP70 levels of the women with PE has the good predictive effect for their adverse pregnancy outcomes.

To analyze the factors influencing the postoperative pain of the uterine artery embolization (UAE) of patients with scar pregnancy. Methods: The clinical data of the patients with scar pregnancy from January 2022 to June 2024 were selected in this study, all of whom received UAE treatment. The postoperative pain of UAE was evaluated by numeric rating scales (NRS). The occurrence of the pain within 24h of the patients after UAE surgery was statistically analyzed, and the patients were divided into the group A (patients with pain intervention) and group B (patients without pain intervention). The age, the number of cesarean section, the preoperative neutrophil to lymphocyte ratio (NLR), and the sore of hospital anxiety and depression scale (HADS) of the patients in the two groups were counted. Logistic regression analysis was conducted to analyze the influencing factors of the postoperative pain of the patients with UAE, and the prediction model was constructed and evaluated. Results: In 130 patients underwent UAE successfully, 2 cases were excluded because of the incomplete data collection and 3 cases withdrew by themselves. In 125 patients, the incidence of the postoperative pain within 24 h after UAE was 44.8% (56/125). Logistic regression showed that the dysmenorrhea history (OR=4.728), the HADS score (OR=2.244), the low pain threshold (OR=0.150), the preoperative higher NLR (OR=10.254), the embolization agent of polyvinyl alcohol (OR=2.762) of the pregnant women with scar pregnancy were the influential factor of their postoperative pain after UAE. The 
postoperative pain prediction model was Logit(P)=-5.788+1.554× dysmenorrhea history (no=0, yes=1) 0.808×HADS score (score)-1.895× pain threshold (kg/cm2) +2.328× preoperative NLR+1.016× type of embolic agent (gelatin sponge=0, Pva granules=1). Receiver operating characteristic (ROC) curve was drawn to show that the area under the curve (AUC) of this model for predicting the postoperative pain of the patients with scar pregnancy after UAE was 0.923. Conclusion: The incidence of the postoperative pain of the patients with scar pregnancy after UAE is higher. The model based on the analyzed factors affecting the postoperative pain of the patients with scar pregnancy after UAE has good predictive efficacy, which can provide the reference for clinical management of these patients.

To analyze the risk factors of the postpartum stress urinary incontinence (PSUI) of pregnant women with advanced age, and to construct the prediction model for the postpartum PSUI of the women. Methods: The clinical data of 120 pregnant women with advanced age who were re-examined in the hospital from November 2020 to November 2023 were included in this study. These women were divided into group A (women with PSUI) and group B (women without PSUI) according to the occurrence of PSUI of the women after postpartum 6 months. The general data of the women were analyzed and compared between the two groups. The related factors affecting the PSUI occurrence of the women was analyzed by logistic regression, and based on which, a predictive model of the PSUI occurrence of the women was constructed. The predictive value of this model for the PSUI occurrence of the women was evaluated by receiver operator characteristic (ROC) curve. Results: The incidence of the postpartum PSUI was 37.5% in 120 pregnant women with advanced age. The age, the values of the neonatal weight and the neonatal parietal diameter, the proportions of the family history of PSUI, the vaginal delivery and the second stage of labor duration ≥2 hours of the women in group A were significantly higher than those of the women in group B. Multivariate logistic stepwise regression analysis showed that the advanced age (OR=2.413), the neonatal high birth weight (OR=2.633), the long fetal parietal diameter (OR=2.106), the family history of PSUI (OR=3.047), the vaginal delivery (OR=3.789) and the duration of the second stage of labor ≥2 hours (OR=3.404) of the pregnant women were the independent factors affecting their PSUI occurrence (all P<0.05). ROC curve analysis showed that the optimal cut-off value, the area under the curve, the sensitivity and the specificity of the model constructed based on these independent factors for predicting the PSUI occurrence of the women were 0.930, 0.841, 91.1% and 66.7%, respectively. Conclusion: The incidence of the PSUI of the pregnant women with advanced age is high, and which is affected by the factors related to the age, the neonatal weight, the neonatal parietal diameter, the family history of PSUI, the delivery mode and the duration of the second stage of labor of the women. The established prediction model has good predictive efficiency for the PSUI occurrence of the pregnant women with advanced age, which is expected to provide a theoretical basis for screening PSUI in the future. 

To investigate the risk factors of the intraoperative hypothermia of women with high-risk during cesarean section. Methods: A retrospective study was conducted on 206 pregnant women with high-risk who underwent cesarean section in the hospital from August 2022 to August 2024. These women were divided into group A (women with intraoperative hypothermia) and group B (women without intraoperative hypothermia) based on their occurrence of the intraoperative hypothermia or not. The general demographic data, the pregnancy complications, the preoperative and intraoperative data of the women in the two groups were collected. Univariate and logistic regression analyses were used to identify the independent factors affecting the intraoperative hypothermia of the women with high-risk during cesarean section, and a prediction model based on these independent factors was constructed, and the predictive efficacy and the consistency of this prediction model were evaluated. Results: Among 206 pregnant women with high-risk, there were 68 (33.0%) women with the intraoperative hypothermia during cesarean section. Multivariate logistic regression analysis showed that the independent risk factors of the intraoperative hypothermia of the women included the conversion to cesarean section and the increased intraoperative fluid loss, while the active intraoperative warming during cesarean section was an independent protective factor (P<0.05). Based on these independent factors, a prediction model was constructed. Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC), the sensitivity and the specificity of this model for predicting the intraoperative hypothermia of the women during cesarean section were 0.868, 83.82% and 78.26%, respectively. The Hosmer-Lemeshow test demonstrated that the prediction model has good consistency (P>0.05). Conclusion: The incidence of the intraoperative hypothermia of the pregnant women with high-risk during cesarean section is relatively high. The conversion to cesarean section and the increased intraoperative fluid loss of the women are the independent risk factors of their intraoperative hypothermia occurrence, while the active intraoperative warming during cesarean section is an independent protective factor to avoid their intraoperative hypothermia occurrence. The risk model constructed based on these factors shows the good predictive efficacy and calibration, which can provide the evidences for the clinical early warning and the development of the nursing intervention measures.

To explore the occurrence and the risk factors of epidural analgesia maternal fever (ERMF) of pregnant women during delivery. Methods: Retrospectively collected data of 1275 pregnant women who had undergone the labor epidural analgesia during delivery in the hospital. These women were divided into group A (226 cases with ERMF) and group B (1049 cases without ERMF). Logistic regression analysis was used to identify the independent risk factors of ERMF. Results: The incidence of ERMF among 1275 women was 17.7% (226/1275). Logistic regression analysis results showed that the higher BMI (OR=2.038, 95%CI 1.113-3.724), the more vaginal examinations (OR=1.375, 95%CI 1.035-1.829), the premature rupture of membranes (OR=1.409, 95%CI 1.050-1.913), the oxytocin used (OR=5.160, 95%CI 1.817-14.66), the polluted amniotic fluid (OR=3.056, 95%CI 1.446-6.461), and the long labor analgesia duration (OR=1.531，95%CI 1.115-2.107) of the women were the risk factors of their ERMF (all P<0.05), while the pre-labor antibiotic used (OR=0.463, 95%CI 0.248-0.865) of the women was the protective factor of their ERMF (P<0.05). Conclusion: The occurrence of ERMF of the pregnant women is associated with their BMI, vaginal examination frequency, premature rupture of membranes, oxytocin used, polluted amniotic fluid, prolonged analgesia duration and pre-labor antibiotic used. 

To evaluate the distinguish value of the median multiple of the soluble vascular endothelial growth factor receptor-1 (sFlt-1)/the placental growth factor (PlGF) ratio of pregnant women with suspected preeclampsia (PE) for predicting their preeclampsia and small for gestational age fetuses complication with small for gestational age (SGA) fetuses. Methods: A total of 967 single pregnant women with suspected PE who underwent regular prenatal care after 20 gestational weeks in the hospital from July 2022 to July 2023 were included in this study. The baseline information, such as the conventional clinical and laboratory results, and the levels of the sFlt-1 and PLGF, 
and the pregnant outcomes after follow-up to delivery of the women were collected. These women were divided into four groups according to their onset of PE and/or SGA, which including group A (women with PE complication with SGA fetus), group B (women with PE), group C (women with SGA fetus) and control group (women without PE and SGA). The baseline information, the levels of sFlt-1 and PLGF, the MoM of sFlt-1/PLGF and the maternal and infant outcomes of the women were compared among the four groups. Receiver operating characteristic curve (ROC) was adopted to analyze the distinguish values of the levels of sFlt-1 and PLGF, the MoM and absolute values of sFlt-1/PLGF, and the multi-parameter prediction model of the pregnant women with suspected PE for predicting their PE and SGA. The survival curves were used to analyze the hazard ratio of MoM of sFlt-1/PlGF of the women for their delivery immediately. Results: The women in group A had the highest MoM (P25, P75) of sFlt-1 level of 9.14 (2.91, 16.86) and sFlt-1/PLGF ratio of 110.27 (14.29, 360.63), and had the lowest MoM (P25, P75) of the PLGF level of 0.12 (0.06, 0.30), and all which of the women in group A were significantly different from those of the women in the other three groups (P<0.001). The maternal and infant outcomes of the women in group A were the worst among the four groups (P<0.001). The sFlt-1/PLGF MoM value of the pregnant women had the excellent predictive discrimination ability for their PE complication with SGA (AUC=0.942), and which was superior to that of the prediction model established based on the other forms of angiogenesis factors and the routine clinical and laboratory indicators of the women (AUC=0.927), with the cutoff value, the sensitivity, the specificity, the positive predictive value, the negative predictive value and the Youden index of 11.788, 80%, 92.6%, 45.53%, 98.34%, and 0.726. The median of the interval time from enrollment to delivery of the women was 2 weeks when their sFlt-1/PLGF MoM ≥11.788, and the median of the interval time from enrollment to delivery of the women was 10 weeks when their sFlt-1/PLGF MoM <11.788, and which had significant difference in the interval time from enrollment to delivery between the women with sFlt-1/PLGF MoM ≥11.788 and the women with sFlt-1/PLGF MoM <11.788 (Log Rank χ2=173.179, P<0.001). Conclusion: The MoM of sFlt-1/PLGF of the pregnant women with the suspected PE has excellent predict and distinguish ability for their PE complication with SGA, and it is even better than the multi-parameter prediction model established based on the conventional clinical and laboratory indicators of the women, and which can be used as an effective prediction tool for the PE and SGA of the pregnant women. When the sFlt-1/PLGF MoM of the women was ≥11.788, it indicates that there is the high risk of delivery of the women within 2 weeks, so it is needs to strengthen the monitoring frequency and the timely clinical intervention.

To analyze the influencing factors of the contrast agent reflux in transvaginal four-dimensional hysterosalpingo-contrast sonography (TVS 4D-HyCoSy) examination of infertility patients. Methods: A retrospective study was conducted to collect the clinical data of 352 infertile patients who were treated in the hospital from August 2021 to August 2024. According to the angiography images of the patients, 352 infertility patients were divided into 135 (38.4%) cases with the contrast agent reflux in group A and 217 (61.7%) cases without the contrast agent reflux in group B. The general data of the patients were compared between the two groups. The various factors of the patients on influencing their contrast agent reflux in the TVS 4D-HyCoSy examination were tested by binary logistic regression, and the decision tree model of the contrast agent reflux in the TVS 4D-HyCoSy examination of the patients was constructed based on these influence factors. Receiver operating characteristic (ROC) curve was drawn to analyze the predictive efficacy of the decision tree model for the contrast agent reflux in the TVS 4D-HyCoSy examination of the patients. Results: Among 135 patients with the contrast agent reflux in the TVS 4D-HyCoSy examination, there were 71(52.6%) cases with the myometrial reflux, 18(13.3%) cases with parametrial venous plexus reflux and 46(34.1%) cases with the mixed reflux. The proportions of the secondary infertility, the endometrial thickness ≤6 mm, the bilateral fallopian tube obstruction, the examination in the 3 second to 4 fourth day after menstruation, the adenomyosis and the history of uterine surgery of the patients in group A were significantly higher than those of the patients in group B (P<0.05). Binary logistic regression analysis showed that the secondary infertility, the endometrial thickness ≤6 mm, the bilateral fallopian tube obstruction, the examination in the 3 second to 4 fourth day after menstruation, the adenomyosis and the history of uterine surgery of the patients were the independent risk factors of their contrast agent reflux in the TVS 4D-HyCoSy examination (OR>1, P<0.05), and the decision tree model was constructed based on these influencing factors. There were total 5 explanatory variables were screened out for the decision tree model, which included the fallopian tube patency, the infertility type, the endometrial thickness, the adenomyosis and the examination time after menstruation, and among them, the fallopian tube patency was the most important root node variable and the most important predictor. The area under the curve (AUC) of this decision tree model for predicting the contrast agent reflux in the TVS 4D-HyCoSy examination of the patients was 0.751(95%CI: 0.701-0.802, P<0.001), and the sensitivity, the specificity and the Youden index of which were 0.659, 0.687 and 0.346, respectively. Conclusion: The secondary infertility, the endometrial thickness ≤6 mm, the bilateral fallopian tube obstruction, the examination in the 3 second to 4 fourth day after menstruation, the history of uterine surgery and the adenomyosis of the infertility patients were the independent risk factors of their contrast agent reflux in the TVS 4D-HyCoSy examination, and the decision tree model based on the these influencing factors has good predictive value for the contrast agent reflux and has certain guiding significance for preventing the contrast agent reflux.

To explore the correlation between the peripheral blood platelet distribution width (PDW) and the placental protein 14 (PP14) level of pregnant women with preeclampsia (PE) and their pregnancy outcomes. Methods: The clinical data of 200 pregnant women with PE from January 2022 to January 2024 were selected in the study. These women were divided into group A (120 women with mild PE) and group B (80 women with severe PE) according to the PE severity of the women. Meanwhile, 100 normal pregnant women were selected in the control group. The PDW of these women were detected by the automatic blood cell analyzer, and the PP14 level of these women were detected by enzyme linked immunosorbent assay. According to the pregnancy outcomes, the women in the study group were divided into group C (141 women with normal pregnancy outcomes) and group D (59 women with adverse pregnancy outcomes). The influencing factors of the pregnancy outcomes of the women with PE were explored by multivariate logistic stepwise regression analysis. Receiver operator characteristic (ROC) curve was drawn to evaluate the values of the PDW and the PP14 level of the women with PE for predicting their pregnancy outcomes. Results: The PDW (18.96±2.27%) and the PP14 level (194.37 ±50.59 pg/L) of the women in the study group were significantly higher than those (16.10%±1.29% and 102.54±28.71 pg/L) of the women in the control group, and which of the women in group B were significantly higher than those of the women in group A. The values of 24h urinary protein, systolic blood pressure, diastolic blood pressure and PDW, and the PP14 level of the women in group D were significantly higher than those of the women in group C (all P<0.05). Multivariate logistic regression analysis showed that the increased 24h urinary protein (OR=2.298), PDW (OR=3.093) and PP14 (OR=3.149) of the women with PE were the risk factors affecting their pregnancy outcomes (P<0.05). The area under the curve of the PDW, the PP14 level or the combination of the PDW and PP14 level of the women with PE for predicting their adverse pregnancy outcomes were 0.733, 0.806 or 0.922, respectively, and the predictive efficiency of the combination of the PDW and PP14 level of the women with PE for predicting their adverse pregnancy outcomes was the highest (Z=9.751, 10.076, P<0.05). Conclusion: The PDW and the PP14 levels of the women with PE increase, and which are involved in the occurrence and development of PE of the women. The combination of the PDW and PP14 level of the women with PE may become a potential indicator for predicting their pregnancy outcomes.

To analyze the changes of the serum carbohydrate antigen (CA125) and human epididymis protein 4 (HE4) levels of patients with endometrial cancer, and to evaluate their clinical significances for evaluating the lymph node metastasis of the patients. Methods: The clinical data of 104 patients with endometrial cancer diagnosed and treated in the hospitals from January 2022 to January 2024 were collected. These patients were divided into two groups, including 21 patients with metastasis in group A and 83 patients without metastasis in group B. The differences of the serum CA125 and HE4 levels among the patients with endometrial cancer and with different clinical data and pathological characteristics were analyzed to identify the risk factors of the lymph node metastasis of the patients. Spearman correlation coefficient analysis was conducted to discuss the correlation between the CA125 and HE4 levels of the patients with endometrial cancer and their lymph node metastasis. The predictive values of the CA125 and HE4 levels of the patients with endometrial cancer for their lymph node metastasis were analyzed. Results: The proportions of the patients with age ≥60 years old, the depth of the myometrial invasion ≥1/2, the diffuse type lesions, and the levels of serum CA125 and HE4 of the patients in group A were significantly higher than those of the patients in group B (all P<0.05). Multivariate logistic regression analysis showed that the depth of myometrial invasion ≥1/2, the diffuse type lesions, the elevated serum CA125 and HE4 levels of the patients with endometrial cancer were the independent factors influencing their lymph node metastasis (P<0.05). Spearman correlation coefficient showed that the serum CA125 and HE4 levels of the patients with endometrial cancer were positively correlated with their lymph node metastasis (P<0.05). The area under the curve and the specificity of the serum CA125 level combined with the HE4 level of the patients with endometrial cancer for predicting their lymph node metastasis were 0.860 and 88.5%. Conclusion: The serum CA125 and HE4 levels of the patients with endometrial cancer are closely related to their lymph node metastasis. The combination of the serum CA125 and HE4 levels of the patients with endometrial cancer for predicting their lymph node metastasis can improve the value.

To explore the differential diagnostic efficacy of the ultrasound BI-RADS grading combined with the serum tumor markers for the benign and malignant breast tumors of patients. Methods: A retrospective analysis was conducted on 145 patients with breast tumor in the hospital from January 2022 to December 2023. Based on the pathological results of these patients, the differential diagnostic value of the ultrasound BI-RADS grading and the levels of the serum carbohydrate antigen 153 (CA15-3), CA125 and carcinoembryonic antigen (CEA) of the patients for their benign and malignant breast tumors was analyzed. Results: Among 145 patients with breast tumor, there were 75 cases diagnosed with benign breast tumors and the main type tumor (56.0%) was the fibroadenoma being, and there were 70 cases diagnosed with malignant breast tumors, mainly including the invasive ductal carcinoma (41.4%), intraductal carcinoma in situ (25.7%) and invasive lobular carcinoma (18.6%). The detection rates of the internal calcification and the irregular lesion morphology of the breast tumors mass, and the abnormal lymph nodes of the patients with malignant breast tumors were significantly higher than those of the patients with benign breast tumors (P<0.05). The consistency between the ultrasound BI-RADS grading diagnosis and the histopathological diagnosis for the breast tumors of the patients was strong (kappa value=0.751, P<0.001). Among the tumor serum markers, CA15-3 showed the highest consistency with the pathological diagnosis for diagnosing the breast tumors of the patients (kappa value=0.542, P<0.001), while serum CA125 and CEA showed moderate consistency with the pathological diagnosis for diagnosing the breast tumors of the patients (kappa value=0.346, 0.317, P<0.001). The diagnostic efficacy of the ultrasound BI-RADS grading combined with the serum tumor markers of the patients with breast tumors for their benign or malignant tumors was significantly higher than that of the ultrasound BI-RADS grading or the serum tumor markers alone (P<0.05), with the sensitivity, the specificity and the accuracy of 91.4%, 96.0% and 93.8%, respectively. Conclusion: The combination of the ultrasound BI-RADS grading and the serum CA15-3, CA125 and CEA levels of the patients with breast tumors can help improve the accuracy for differential diagnosing their benign and malignant tumors, and which has important value in the clinical diagnosis of the breast tumors.

To explore the correlation between the expression levels of helper T cell 9 (Th9) and hepatocyte growth factor receptor (c-Met) protein of patients with cervical cancer after concurrent chemoradiotherapy and their progression of disease. Methods: This study adopted a case-control study protocol to select 67 patients with cervical cancer confirmed by pathological examination (in group A), 70 patients with cervical intraepithelial neoplasia (in group B) and 70 patients with chronic cervicitis (in group C) were selected from the oncology department of the hospital from January 2023 to December 2024. The expression levels of the Th9 protein in peripheral blood and the c-Met protein in the tissue samples of the patients were compared among the three groups. The differences of the expressions of Th9 and c-Met proteins were compared among the women with different pathological characteristics. According to whether the disease progression occurred of the patients with cervical cancer after concurrent chemoradiotherapy, the correlation between the levels of Th9 and c-Met proteins of the patients with cervical cancer and their disease progression was analyzed by multivariate model. Results: The Th9 cells and c-Met protein expressions of the patients in group C, in group B and in group A had increased gradually (P<0.05). There was significant difference in the expression level of Th9 cells in peripheral blood among the patients with different tumor differentiation, among the patients with different lymph node metastasis or among the patients with different FIGO stage in group A. There was significant differences in the positive expression rate of c-Met in the cervical cancer tissues among the patients with different lymph node metastasis and among the patients with different FIGO stage in group A (all P<0.05). The logistic regression model showed that the poor tumor differentiation, the lymph node metastasis, the FIGO stage of Ⅲ-Ⅳ, the increased expression of Th9 cells and the positive expression of c-Met protein of the patients with cervical cancer after concurrent chemoradiotherapy were the independent risk factors of their disease progression (all P<0.05). Conclusion: The expression of Th9 cells in the peripheral blood and the positive expression rate of c-Met protein in the lesion tissue of the patients with cervical cancer are increased, which are related to the disease progression of the patients after concurrent chemoradiotherapy. 

To construct a prediction model of the pelvic infection of patients with cervical cancer after surgery, and to verify the effect of this prediction model. Methods: 199 patients with cervical cancer who underwent surgery in the hospital were selected for constructing and validating a prediction model, which included 139 cases were used for model construction and 60 cases were used for validation. The model was constructed by univariate and logistic regression analysis. The predictive ability and fitting degree of this model were evaluated by receiver operating characteristic (ROC) curve and Hosmer-Lemeshow test. Results: The incidence of the pelvic infection of the patients with cervical cancer after surgery was 12.1% (24/199). Univariate and logistic regression analyses showed that the influencing factors of the pelvic infection of the patients with cervical cancer after surgery included the history of diabetes, the history of pelvic infection, the chronic pelvic pain, the laparotomy, the durations of surgery >2h and the hospital stay >7d (all P<0.05). Hosmer-Lemeshow test showed P=0.683, and the area under ROC curve, the sensitivity and the specificity of the model for predicting the pelvic infection of the patients were 0.893, 0.832 and 0.817, respectively. Conclusion: The prediction model for the postoperative pelvic infection of the patients with cervical cancer established in this study based on the factors of the patients, such as the history of diabetes, the history of pelvic infection, the chronic pelvic pain, the surgical method, the duration of surgery, and the hospital stay, has good prediction effect for predicting the pelvic infection of the patients, and which can be applied for screening the postoperative pelvic infection of the patients with cervical cancer after surgery. 

To explore the independent risk factors of the occurrence of cancer-related fatigue (CRF) of patients with gynecologic malignancy chemotherapy, and to construct a prediction model. Methods: The clinical data of 191 patients with gynecologic malignancy chemotherapy were collected in this study retrospectively. 191 patients from January 2021 to August 2023 were included in the modeling group and 51 patients from September 2023 to September 2024 were included in the validation group. Logistic regression analysis was used to identify the risk factors of the CRF of the patients with gynecologic malignancy chemotherapy and the construction of a prediction model. The predictive efficacy of this model was evaluated by receiver operating characteristic (ROC) curve, calibration curve, Hosmer-Lemeshow test and DCA curve. Results: In the included 242 patients, there were 214 (88.4%) patients with CRF. The age ≥60 years old, the HADS score >10 points and the PSQI score >5 points of the patients with gynecologic malignancy chemotherapy were the risk factors of their CRF occurrence, and the education level of high school or above, the regular exercise and the SSRS score >30 points of the patients were the protective factors of their CRF occurrence (all P<0.05). ROC curve analysis showed that the area under the curve of the patients in the modeling group and in the validation group were 0.894 (95%CI 0.829-0.958) and 0.884 (95%CI 0.789-0.979). The Hosmer-Lemeshow tests showed that all P values were >0.05, and the calibration curve showed the good model fit. The DCA curve showed that this model had certain practicability. Conclusion: This study analyzes the independent risk factors of the CRF of the patients with gynecologic malignancy chemotherapy, and a risk prediction model for the CRF was constructed based on these risk factors. This model has good predictive efficacy and clinical value, which provides the effective tools for clinical identifying the patients with high-risk risk and for relieving the fatigue symptoms of the patients.

To detect the chromosome aneuploidy and copy number variation (CNV) abnormalities of missed aborted embryos by low depth whole genome high throughput sequencing. Methods: In this case-control study, 449 women with missed abortion who admitted to the hospital from January 2022 to January 2024 were selected in study group, and 120 healthy pregnant women who voluntarily performed induced abortion in the hospital were selected in control group during the same period. The low depth whole genome high throughput sequencing was performed for the abortion embryos of the women in the two groups. The chromosome aneuploidy and the CNV abnormality (deletion and duplication) of the aborted embryos were compared between the two groups. Results: The chromosomes of the embryos of the women in the control group were all normal. In the study group, there were 301 (61.0%) cases with the embryo chromosomal aneuploidy, and which had statistically significantly different from that of the women in the control group (P<0.05). In the study group, the embryo chromosomal aneuploidy included 162 (53.8%) cases with trisomy 16, 56 (18.6%) cases with trisomy 22, 33 (11.0%) cases with trisomy 15, 31 (10.3%) cases with trisomy 21 and 19 (6.3%) cases with trisomy 6. The embryo CNV of the women in the control group was normal in all cases. There were 332 (73.9%) cases with the embryo abnormal CNV in the study group, and which had statistically significantly different from that in the control group (P<0.05). Among 332 cases with abnormal embryo CNV in the study group, there were 203 (61.1%) cases with CNV deletion and 129 (38.9%) cases with CNV duplication. Conclusion: The chromosome aneuploidy and CNV abnormality of the embryos of the women are relatively high with their missed aborted. The low depth whole genome sequencing with high throughput can be used for the genetic analysis of the missed aborted embryos.

Matrix metalloproteinases (MMPs) are the calcium-zinc-dependent proteases that break down the extracellular matrix (ECM), and their activities are regulated by the tissue inhibitors of metalloproteinases (TIMPs), and which can be involved in many tissue remodeling processes and influence the normal course of pregnancy through the degradation of the ECM. MMP2 and MMP9 are the members of the MMPs family, and which can be involved in placental development, embryo implantation, and other pregnancy processes through a variety of mechanisms during early pregnancy. Numerous studies at home and abroad had found that the early spontaneous abortion is related to MMP2 and MMP9, therefore, this paper reviews the role of MMP2 and MMP9 in the occurrence of the early spontaneous abortion.