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| Predictive value of the serum placental leucine aminopeptidase and nesfatin 1 levels of pregnant women during the first trimester of pregnancy for their gestational diabetes mellitus |
| 1.Ningnan County People's Hospital, Sichuan Province, 615400；2. The First People's Hospital of Liangshan Yi Autonomous Prefecture, Xichang, Sichuan Province |
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Abstract To investigate the predictive value of the levels of serum placental leucine aminopeptidase (P-LAP) and nesfatin 1 (NSF-1) of pregnant women during the first trimester of pregnancy for their gestational diabetes mellitus (GDM). Methods: The pregnant women during the first trimester of pregnancy who received prenatal examination in hospital were selected as the research objects from January 2020 to June 2020. The fasting venous blood in the morning of these women during 6-12 gestational weeks was collected to detect the serum P-LAP and NSF-1 levels and the glucose and lipid metabolism indicators values of the women. The GDM screening was performed for the women during 24-28 gestational weeks, and based on the GDM screening results, the women were divided into group A (women with GDM) and group B (women with normal glucose tolerance (NGT)). The clinical data of the women were compared between the two groups. Logistic regression model was used to analyze the influencing factors of GDM, and receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of the serum P-LAP and NSF-1 levels of the women for their GDM. Results: A total of 284l pregnant women were included in this study, of which, 61 women were diagnosed as GDM, with the incidence of 21.5%. The body mass index (BMI) value, the levels of fasting blood glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin (FINS), and serum NSF-1 of the women in group A were significantly higher than those of the women in group B, and the P-LAP level of the women in group A was significantly lower (all P＜0.05). Logistic regression analysis showed that the abnormal P-LAP and NSF-1 levels of the women were the independent factors influencing their GDM occurrence (P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of the serum P-LAP level and the NSF-1 level of the women for predicting their GDM were 0.799 and 0.808, the sensitivity of which were 95.1% and 52.9%, and the specificity of which were 65.6% and 88.3%. The AUC, the sensitivity, and the specificity of the combined serum P-LAP and NSF-1 levels of the women for predicting their GDM were 0.872, 78.7%, and 81.2%, respectively. Conclusion: Both the decrease of the serum P-LAP level and the increase of the NSF-1 level of the pregnant women during the first trimester of pregnancy are the independent risk factors of their GDM, and which have high predictive value for the GDM occurrence of these women.
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