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| Changes of the white blood cell count, and the levels of fasting blood glucose, serum creatinine, and alanine aminotransferase of pregnant women with gestational diabetes mellitus and their early screening and risk evaluation of gestational diabetes mellitus |
| Wuhu First People’s Hospital, Wuhu, Anhui Province, 241000 |
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Abstract To investigate the white blood cell count (WBC), and the levels of fasting blood glucose (FBG), serum creatinine (Cr), and alanine aminotransferase (ALT) of pregnant women with gestational diabetes mellitus (GDM), and to study their values for the early screening and risk evaluation of GDM. Methods: The clinical data of 542 pregnant women who had undergone antenatal examination from May 2020 to December 2021 were analyzed retrospectively. These women were divided into study group (60 women with GDM) and control group (482 women without GDM). The differences of the WBC, and the levels of FBG, Cr, and ALT of the women were compared between the two groups. Spearman correlation coefficient was used to analyze the correlation between the WBC, and the levels of FBG, Cr, and ALT of the women and their GDM occurrence. Receiver operator characteristic (ROC) curve was drawn to analyze the efficacy of the WBC, and the levels of FBG, Cr, and ALT of the women for early screening their GDM. Multivariate regression analysis was used to analyze the related risk factors of GDM occurrence. Results: The WBC, and the levels of the Cr, FBG, and ALT of the women in the study group were significantly higher than those of the women in the control group, and which of the women were all positively correlated with their GDM occurrence (all P＜0.05). ROC analysis showed that the area under the curve of the combined detections of WBC, and the levels of FBG, Cr, and ALT of the women for predicting their GDM occurrence was 0.851, and which was the highest, with the sensitivity of 90.1% and the specificity of 87.6%. The WBC ≥6.41×109/L, the FBG level ≥5.16mmol/L, ALT≥14.98U/L, the value of body mass index ≥22.32kg/m2, the Cr level ≥50.62μmol/L, and smoking of the women were the risk factors of their GDM occurrence, while the bachelor's degree or above of the educational level of the women was the protective factor of their GDM occurrence. Conclusion: The WBC, and the levels of Cr, FBG, and ALT of the women with GDM increase, and the combined detections of the WBC, and the levels of Cr, FBG, and ALT of the women has certain predictive efficacy for their early screening GDM. The maternal controlled BMI, the reduced smoking frequency, and the increased knowledge reserve may play a certain role in reducing the GDM occurrence of the pregnant women.
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