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| Predictive values of the levels of serum human epididymal secretion protein 4, transmembrane 4-L six-family-1 and heat shock protein 90α(HSP90α) of women with ovarian cancer for their postoperative recurrence |
| Beijing Daxing District People's Hospital, Beijing, 102600 |
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Abstract To explore the predictive value of the combined levels of serum human epididymal secretion protein 4 (HE4), transmembrane 4-L six-family-1 (TM4SF1) and heat shock protein 90α (HSP90α) of women with ovarian cancer (OC) for their postoperative recurrence. Methods: The clinical data of 122 women with OC (in group A) who had undergone surgical treatment in the hospital from October 2018 to December 2020 were selected in this study, and these women were divided into group A1 (85 women without OC recurrence) and group A2 (37 women with OC recurrence) according to the postoperative recurrence situation of these women within 3 years of follow up after surgery. 102 women with benign ovarian tumor who also had been treated in the hospital during the same period were included in group B, and 115 healthy women who had undergone physical examinations in the hospital were included in group C. The levels of serum HE4, TM4SF1, and HSP90α of the women were compared among group A, group B and group C. Logistic regression was applied to analyze the influencing factors of the postoperative OC recurrence of the women in group A. Receiver operating characteristic (ROC) curve was applied to analyze the predictive values of the levels of serum HE4, TM4SF1, and HSP90αof the women in group A for their postoperative OC recurrence. Results: The levels of serum HE4 (158.49±41.27 pmol/L), TM4SF1 (171.28±42.33 ng/ml) and HSP90α(79.22±15.38 ng/ml) of the women in group A were significantly higher than those (34.53±8.39 pmol/L, 111.18±25.46 ng/ml and 58.19±10.24 ng/ml) of the women in group B and those (33.31±8.12 pmol/L, 102.37±22.39 ng/ml and 56.22±9.27 ng/ml) of the women in group C. The serum HE4, TM4SF1, HSP90αlevels of the women in group A2 were significantly higher than those of the women in group A1 (all P<0.05), while which of the women in group B had no significantly different from those of the women in group C (P>0.05). Logistic regression analysis showed that the FIGO stage III, poor differentiation and lymph node metastasis of OC, and the increased levels of serum HE4, TM4SF1 and HSP90α of the women with OC were the influencing factors of their postoperative OC recurrence. ROC curve analysis showed that the area under curve (AUC) of the HE4 level, the TM4SF1 level, and the HSP90α level of the women with OC for predicting their postoperative OC recurrence were 0.874, 0.828 and 0.872, respectively, the sensitivity of which were 89.2%, 89.2% and 89.2%, respectively, and the specificity of which were 66.8%, 69.2% and 63.3%, respectively. The AUC, the sensitivity and the specificity of the combined levels of serum HE4, TM4SF1 and HSP90αof the women with OC for predicting their postoperative OC recurrence were 0.958, 86.5%, and 78.3%, respectively, and the AUC of the combined levels of serum HE4, TM4SF1 and HSP90α of the women with OC for predicting their postoperative OC recurrence was the best (P<0.05). Conclusion: The levels of serum HE4, TM4SF1, and HSP90α of the women with the postoperative OC recurrence all elevate abnormally, and which are the risk factors of the postoperative OC recurrence of the women. The combined levels of serum HE4, TM4SF1 and HSP90α of the women with OC for predicting their postoperative OC recurrence has certain value.
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