To explore the effects of combined resistance-aerobic exercise of pregnant women with gestational diabetes mellitus (GDM) on their blood glucose level, oxidative stress, and pregnancy outcomes. Methods: 150 pregnant women with GDM were selected as the research objects, and were randomly divided into control group (n=75) and observation group (n=75) from March 2021 to February 2022. The women in the both groups had received routine GDM management, the women in the control group were given aerobic exercise intervention additionally, and the women in the observation group were given impedance-aerobic exercise combined intervention additionally. The levels of blood glucose, such as fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG), and glycosylated hemoglobin (HbA1c), the levels of blood lipids, such as total cholesterol (TC) and triglyceride (TG), the levels of oxidative stress indexes, such as malondialdehyde (MDA), superoxide dismutase (SOD), and 8-hydroxydeoxyguanosine (8-OHdG), and the pregnancy outcomes of the women before and after intervention were compared between two groups. Results: The levels of blood FBG, 2hPBG, HbA1c, TC, TG, MDA, and 8-OHdG of the women in the observation group after intervention were significantly lower than those of the women in the control group, while the serum level of SOD of the women in the observation group was significantly higher. The rate of cesarean section (31.3%), the amount of postpartum blood loss (235±65ml), and the incidence of macrosomia (0) of the women in the observation group were significantly lower than those (40.0%, 313±88ml, and 9.3%) of the women in the control group, and the Apgar score at 1min after birth (9.9±0.3 points) in the observation group was significantly higher than that (9.7±0.5 points) in the control group (all P<0.05). Conclusion: The combined resistance-aerobic exercise is beneficial for the pregnant women with GDM to control the blood glucose and lipids levels, which can reduce the oxidative stress and improve the pregnancy outcomes of these women.