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| Effects of the pelvic floor biomimetic electrical stimulation therapy for patients with thin endometrium infertility on their endometrial receptivity and pregnancy outcomes |
| Sanmen County People's Hospital, Sanmen, Zhejiang Province, 317100 |
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Abstract To observe the effects of pelvic floor biomimetic electrical stimulation therapy for patients with thin endometrium infertility on their endometrial receptivity and pregnancy outcomes. Methods: 8 patients with mesosterenotic endometrial infertility were randomly divided into observation group (40 cases given conventional hormone therapy combined with pelvic floor biomimetic electrical stimulation) and control group (40 cases given conventional hormone therapy). The patients in both groups were treated for 3 courses of treatment (1 menstrual cycle as 1 course). The endometrial status, such as the endometrium type, the endometrial thickness (EMT) and the endometrial volume, the values of uterine artery hemodynamic parameters, such as pulsatility index (PI), resistance index (RI) and peak systolic velocity/end diastolic velocity (S/D), and the levels of sex hormones of the patients before treatment and after 3 courses of treatment were compared between the two groups. The pregnancy status of the patients in the two groups within 1 year after the end of treatment was statistically analyzed. Results: After 3 courses of treatments, the proportion (67.5%) of type A endometrium, the EMT (9.48±0.65mm) and the endometrial volume (2.34±0.38 cm2) of the patients in the observation group were significantly higher than those (32.0%, 8.23±0.79mm and 1.71±0.36 cm2) of the patients in the control group, and the levels of serum estradiol (E2) and progesterone (P) of the patients in the observation group were significantly higher than those of the patients in the control group, while the values of uterine artery hemodynamic parameters and the levels of the luteinizing hormone (LH), testosterone (T), folliclestimulating hormone (FSH) and prolactin (PRL) of the patients in the observation group were significantly lower than those of the patients in the control group. The pregnancy rate (42.5%) of the patients in the observation group was significantly higher than that (20.0%) of the patients in the control group (all P<0.05). Conclusion: Pelvic floor biomimetic electrical stimulation adjuvanting the hormone therapy for the patients with thin endometrium infertility can effectively enhance their endometrial receptivity and improve their hemodynamics and sex hormones levels, and it has a positive effect on the improvement of the pregnancy rate of the patients.
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