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| Curative effect of hysteroscopic endometrial polypectomy combined with modified Bazhen decoction for treating patients with endometrial polyps and its impacts on the expressions of the serum estrogen receptor and vascular endothelial growth factor |
| Mingzhou Hospital, Ningbo, Zhejiang Province, 315000 |
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Abstract To study the curative effect of hysteroscopic endometrial polypectomy combined with modified Bazhen decoction for treating patients with endometrial polyps and its impacts on the expressions of the serum estrogen receptor (ER) and vascular endothelial growth factor (VEGF) of the patients. Methods: A total of 120 patients with endometrial polyps were selected and were randomly divided into study group and control group (60 patients in each group) from November 2020 to February 2022. The patients in the study group were treated with hysteroscopic endometrial polypectomy combined with modified Bazhen decoction, and the patients in the control group were treated with hysteroscopic endometrial polypectomy. The serum ER and VEGF levels, the endometrial thickness, the TCM symptom score, the recurrence rate, and the total effective rate of the patients were compared between the two groups. Results: The serum ER and VEGF levels (1.30±0.17 ng/ml and 111.87±15.33 ng/L) of the patients in the study group after treatment for 1 month were significantly lower than those (1.50±0.36 ng/ml and 129.34±16.04 ng/L) of the patients in the control group. The levels of ER and VEGF (0.90±0.12 ng/ml and 91.06±10.16 ng/L) of the patients in the study group after treatment for 3 months were significantly lower than those (1.36±0.19 ng/ml and 109.22±12.31 ng/L) of the patients in the control group. After 3 months of the treatment, the endometrial thickness (6.54±1.38 mm), the recurrence rate of endometrial polypectomy (5.0%), and the TCM symptom score (1.45±0.54 points) of the patients in the study group were significantly lower than those (8.68±1.59 mm, 25.0%, and 2.56±0.87 points) of the patients in the control group. The total effective rate (96.7%) of the patients in the study group was significantly higher than that (78.3%) of the patients in the control group (all P<0.05). Conclusion: Hysteroscopic endometrial polypectomy combined with modified Bazhen decoction for treating patients with endometrial polyps can inhibit the expressions of their serum ER and VEGF, can reduce their recurrence rate of endometrial polyps in three months after operation, and can improve the clinical efficacy.
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