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| Correlation between the infections of mycoplasma and chlamydia in reproductive tract of women of childbearing age and their human papillomavirus infection |
| Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201999 |
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Abstract To explore the correlation between the infections of mycoplasma and chlamydia in reproductive tract of women of childbearing age and their human papillomavirus (HPV) infection. Methods: 567 women of childbearing age who had been given genital tract mycoplasma culture and chlamydia antigen detection from March 2019 to October 2022 were collected. According to the results of the detections of the cervical discharge, these women were divided into group A (women with mycoplasma infection), group B (women with chlamydia infection), group C (women with mycoplasma and chlamydia mixed infection), and control group D (women without infection). The positive rate of HPV of the women was compared among the four groups. The influence of mycoplasma and chlamydia infections of the women on their HPV infection risk was analyzed by logistic regression with the age and other factors included as the covariables. Results: The chlamydia infection rate of the women of childbearing age was 3.4% (19/567), the mycoplasma infection rate was 7.8% (44/567), and the mixed infection rate of chlamydia and mycoplasma was 2.8% (16/567). The positive rate of HPV of childbearing age was 19.7% (112/567), and the highest rate was mainly in the women aged 25-35 years old. The higher positive rates of HPV subtypes infection of the women were all the high-risk HPV, such as HPV 52, HPV 16, and HPV 58. The positive rate of HPV of the women was different among the four groups, with the highest rate (87.5%) of the women in group C, and followed by that (65.9%) of the women in group A. Multiariable logistic regression analysis showed that the mixed infection of mycoplasma and chlamydia in genital tract of the women was the risk factor of their HPV infection (OR=1.732, 95% CI 1.253-1.905). Conclusion: The mixed infection of mycoplasma and chlamydia in genital tract of the women of childbearing age increases the risk of HPV infection，so both of mycoplasma and chlamydia of the women should be paid more attention to screening to prevent their HPV infection.
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