To observe the influencing factors of adverse neonatal outcomes of pregnant women with preeclampsia (PE), and to analyze the intervention countermeasures. Methods: A total of 152 pregnant women with PE admitted to the hospital from October 2018 to October 2022 were collected retrospectively. According to the neonatal outcomes, these women were divided into group A (women with adverse neonatal outcomes) and group B (women with normal neonatal outcomes). The clinical data of the pregnant women with PE were collected. The possible factors influencing the adverse neonatal outcomes of the women were obtained by univariate analysis. Multivariate Logistic regression analysis was used to further determine the independent risk factors of the adverse neonatal outcomes of the pregnant women with PE. Results: Among 152 pregnant women with PE, there were 45 (29.6%) cases in group A and 107 (70.4%) cases in group B. Univariate analysis showed that the systolic and diastolic blood pressure values at admission, the 24h urine protein value, the HbA1c level before delivery, the fetal growth restriction occurrence, and the levels of albumin (ALB), platelet count (PLT), serum creatinine (Cr), aspartate aminotransferase (AST), alanine aminotransferase (ALT) at admission of the women with PE were associated with their adverse neonatal outcomes (P<0.05). Multivariate analysis showed that the 24h urine protein value at admission (OR=1.273, 95%CI 1.063-1.524), the HbA1c level before delivery (OR=1.428, 95%CI 1.094-1.865), and the fetal growth restriction occurrence (OR=4.945, 95%CI 2.274-10.753) of the pregnant women with PE were all the independent risk factors of their adverse neonatal outcomes (all P<0.05). Conclusion: The 24h urine protein value at admission, the HbA1c level before delivery, and the fetal growth restriction occurrence of the pregnant women with PE are all independent correlation with their adverse neonatal outcomes, which should be monitored strengthen and the targeted interventions should be given to improve the quality of birth.