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| Changes of serum vascular endothelial growth factor and brain-derived neurocytotrophic factor levels of women with ovarian endometriosis cyst and their predictive values for the pregnancy outcomes |
| Tangshan Maternal and Child Health Care hospital, Tangshan, Hebei Province, 063000 |
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Abstract To investigate the predictive values of the abnormal expression levels of the serum vascular endothelial growth factor (VEGF)and brain-derived neurocytotrophic factor (BDNF)of women with ovarian endometriosis cyst (OEC)for their pregnancy outcomes. Methods: 152 women with OEC were collected in study group, and 100 women who came to hospital for physical examination were selected in control VEGF and BDNF group from March 2018 to January 2020. The serum of the women in the study group at the time of admission and the women in the control group during physical examination were obtained for detecting the levels of VEGF and BDNF. The pregnancy outcomes of the women in the two groups and the women with different stages of OEC were counted. Receiver operating characteristic curve (ROC)was used to analyze the predictive values of the levels of serum VEGF and BDNF for the pregnancy outcomes of the women with OEC. Results: The levels of serum VEGF and BDNF (406.35±123.27 pg/ml and 1079.22±209.32 ng/L)of the women in the study group were significantly higher than those (305.27±100.34 pg/ml and 659.34±100.24 ng/L)of the women in the control group, which of the women in the study group had increased significantly with the increase of OEC stage, and the levels of which of the women without pregnancy were significantly higher than those of the women with pregnancy, the levels of which of the women with inferior embryos were significantly higher than those of the women with high-quality embryos, the levels of which of the women without abortion were significantly higher than those of the women with spontaneous abortion, and the levels of which of the women with normal pregnancy were significantly higher than those of the women with poor pregnancy (all P＜0.05). ROC curve analysis showed that the AUC of the VEGF level or the BDNF level of the women with OEC for predicting their pregnancy outcomes was 0.748 (95%CI 0.606-0.890)or 0.720 (95%CI 0.581-0.859), the critical values of which was 406.845 pg/ml or 992.071 ng/L, the sensitivity of which was 68.4% or 42.8%, and the specificity of which was 68.0% or 88.0%. The AUC, the sensitivity, and the specificity of the combined VEGF and BDNF levels of the women with OEC for predicting their pregnancy outcomes were 0.919 (95%CI 0.872-0.966), 93.8%, and 30.5%, respectively. Conclusion: The levels of the serum VEGF and BDNF of the women with OEC increase abnormally, and which increase with the elevation of the OEC stage of the women. Early detections of the serum VEGF and BDNF of the women with OEC can assist predicting their pregnancy outcomes in clinical, and the value of the combined detections of the serum VEGF and BDNF of the women for predicting their pregnancy outcomes is higher.
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