To investigate the effect of different doses of mifepristone combined with misoprostol for abortion of early pregnancy of women with scarred uterus. Methods: The clinical data of 104 women with scarred uterus and abortion during the first trimester of pregnancy from September 2017 to September 2020 were collected retrospectively. According to the difference of treatment schemes, these women were divided into two groups. 53 women in group A were given mifepristone (200mg), and then were given oral misoprostol (0.6mg)in the morning after three days of oral mifepristone. 51 women in group B were given oral mifepristone (75mg), after 12h of that, oral mifepristone (25mg)per day for two days, and then were given oral misoprostol (0.6mg)on the third day. The abortion effect and the incidence of adverse reactions of the women were compared between the two groups. Results: The completely abortion rate (94.1%)of the women in group B was significantly higher than that (81.1%)of the women in group A (P＜0.05). There was no significant difference in the menstrual recovery time (40.2±3.9d vs. 39.5±3.6d)of the women between the two groups (P＞0.05). The expel time of gestational sac (3.1±1.1 h)and the vaginal bleeding time (8.1±4.3d)of the women in group B were significantly shorter than those (4.6±1.4 h and 12.2±4.5d)of the women in group A (P＜0.05). There was no significant difference in the total incidence of adverse reactions (54.7% vs.37.7%)of the women between group A and group B (P＞0.05). Conclusion: Mifepristone used continually combined with misoprostol for abortion of the women with scarred uterus can significantly improve their complete abortion rate, and can shorten their expel time of gestational sac and vaginal bleeding time.