|
|
|
| Effect of aspirin combined with prednisone for treating patients with recurrent abortion and its influence on the immune balance and pregnancy outcomes |
| Dalian Women's and Children's Medical Center (Group), Dalian, Liaoning Province, 116000 |
|
|
|
|
Abstract To explore the effect of aspirin combined with prednisone for treating patients with recurrent abortion, and to study its influence on the immune balance and pregnancy outcomes of these patients. Methods: 82 patients with recurrent abortion were selected prospectively, and were divided into two groups by digital table method (41 cases in each group)from January 2018 to January 2020. The patients in the control group received treatment of aspirin, while the patients in the study group received treatment of aspirin combined with prednisone. The levels of serum immune factor, vitamin D, thrombine-activated fibrinolytic inhibitor (TAFI), and the pregnancy outcomes before and after treatment of the patients were compared between the two groups. Results: The total effective rate (97.7%)and the success rate of pregnancy (80.5%)of the patients in the study group were significantly higher than those (78.1% and 58.5%)of the patients in the control group. The rate of preterm birth (24.4%)of the patients in the study group was significantly lower than that (51.2%)of the patients in the control group (all P＜0.05). There were no significant differences in the placental abruption, the premature rupture of membranes, and the live birth rates of the patients between the two groups (P＞0.05). The serum interleukin-2 (IL-2)levels and the IL-2/IL-10 value of the patients in both groups after treatment had decreased significantly, and the IL-10 level of the patients in both groups after treatment had increased significantly, and the IL-2 level (10.28±1.48pg/ml)and the IL-2/IL-10 value (0.89±0.06)of the patients in the study group after treatment were significantly lower than those (12.95±1.74pg/ml and 1.39±0.25)of the patients in the control group. The IL-10 level (11.85±1.48pg/ml)of the patients in the study group after treatment was significantly higher than that (9.73±1.28pg/ml)of the patients in the control group (all P＜0.05). The activated thrombin time (APTT)value of the patients in both groups after treatment had increased significantly, while the levels of platelet (PLT)and fibrinogen (FIB)of the patients in both groups after treatment had decreased significantly. The APTT value (35.8±3.9s)of the patients in the study group after treatment was significantly higher than that (33.81±3.16s)of the patients in the control group. The levels of PLT (153.67±20.24 109/L)and FIB (2.54±0.15g/L)of the patients in the study group after treatment were significantly lower than those (165.83±21.85 109/L and 2.69±0.35g/L)of the patients in the control group. The levels of serum vitamin D and TAFI of the patients in both groups had increased significantly, and the levels of vitamin D (45.71±2.85ng/ml)and TAFI (14.86±1.85μg/ml)of the patients in the study group were significantly higher than those (38.71±3.75ng/ml and 12.75±1.74μg/ml)of the patients in the control group (P＜0.05). There were 1 patient with nausea and vomiting and 1 patient with dizziness in the control group, and there were 2 patients with nausea and vomiting and 1 patient with lower limb edema in the study group. The total incidence of adverse reactions (4.9% vs. 7.3%)of the patients had no significantly different between the two groups. No serious adverse reactions occurred of the patients in the two groups during treatment. The adverse reactions of the patients in both groups had obviously relieved after drug withdrawal. Conclusion: Aspirin combined with prednisone for treating the patients with recurrent abortion can promote their immune balance and improve their pregnancy outcomes, with good safety.
|
|
|
|
|
|
|
|
|
