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| Effects of anesthetic induction with nalbuphine and sufentanil combined with propofol during the hysteroscopic surgery of patients on their bispectral index and anesthetic resuscitation |
| Affiliated Longhua People’s Hospital, Southern Midical University(Longhua People’s Hospital), 518109 |
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Abstract To investigate the effects of anesthetic induction with nalbuphine and sufentanil combined with propofol during the hysteroscopic surgery of patients on their bispectral index and anesthetic resuscitation. Methods: 60 patients who wanted hysteroscopic surgery were selected and were divided into two groups (30 cases in each group)by random number table method between April 2021 and May 2022. The patients in group A were given anesthesia induced by nalbuphine combined with propofol and the patients in group B were given anesthesia induced by sufentanil combined with propofol. The values of systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), oxygen saturation (SpO2), and bispectral index (BIS)of the patients at 5 min before anesthesia(T0), at starting to dilate when the eyelash reflex disappeared (T1), during surgery (T2), at the end of surgery(T3), and at awakening from anesthesia (T4)were compared between the two groups. The doses of induction, maintenance, and total of propofole, the total administration time, the dose in unit time, the awakening time from anesthesia, and the score evaluated by pain numeric rating scale (NRS)at T4, and the adverse reaction rate of the patients were compared between the two groups. Results: The values of SBP, DBP, HR, and SpO2 of the patients in the two groups at T1-T4 were significantly lower than those at T0, and which of the patients in group B was significantly lower than those of the patients in group A. The induction dose of propofol (110.90±14.95mg), the maintenance dose (133.83±26.77mg), and the total administration time (18.70±4.31min)of propofole, the awakening time (10.43±1.17min), and the NRS score at T4 (0.03±0.18 points)of the patients in group A were all significantly lower than those (121.30±18.15mg, 155.33±40.32mg, 22.60±6.72min, 21.33±3.34min, and 0.30±0.47 min)of the patients in group B. The BIS value (54.17±4.47)of the patients in group B at T3 was significantly higher than that (51.67±4.02)of the patients in group A. The total incidence of the adverse reactions (20.0%)during surgery and period of awakening from anesthesia of the patients in group A was significantly lower than that (46.7%)of the patients in group B (all P＜0.05). Conclusion: Both regimens of anaesthetic induction used during hysteroscopic surgery of the patients have effectiveness. The anaesthetic induction with nalbuphine compounded with propofol is significantly superior to sufentanil compounded with propofol in maintaining the vital signs of the patients, in shortening sedation induction time, and in reducing propofol dose, with better safety.
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