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| Influence factors of early spontaneous abortion of women with recurrent spontaneous abortion and the evaluation values of the levels of placental chorionic transmembrane protein CD81 and angiopoietin for their abortion occurrence |
| Wuhan Central Hospital of China Construction Third Engineering Bureau, Wuhan, Hubei Province, 430070 |
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Abstract To explore the levels of placental chorionic transmembrane protein CD81 and angiopoietin (Ang)during prepregnancy of women with recurrent spontaneous abortion (RSA), and to study their values for evaluating the occurrence of spontaneous abortion again of the women during the first trimester of pregnancy. Methods: A total of 105 women with RSA and spontaneous abortion again during the first trimester of pregnancy in the hospital were enrolled in study group between June 2019 and March 2021, and other 110 women with normal pregnancy who wanted termination pregnancy during the first trimester of pregnancy were enrolled in control group. The levels of CD81, Ang1 mRNA, and Ang2 mRNA in placental villi of the women in the two groups were detected by real-time fluorescence quantification PCR (qRT-PCR), and the evaluation values of which for recurrent spontaneous abortion was analyzed by receiver operating characteristic (ROC)curve. The risk factors of spontaneous abortion again of the women with RSA during the first trimester of pregnancy were analyzed by Logistic regression analysis. Results: The mRNA expression levels of CD81 (2.33±0.51), Ang1 (0.36±0.11), and Ang2 (0.38±0.12)of the women in the study group were significantly higher than those (1.67±0.33, 0.18±0.05, and 0.17±0.04)of the women in the control group (all P＜0.05). The area under the curve of the combined detections of the levels of CD81 mRNA, Ang1 mRNA, and Ang2 mRNA in placental villi tissue of the women for evaluating their RSA was 0.898, which were significantly higher than that (0.786, 0.817, or 0.801)of CD81 mRNA level, Ang1 mRNA level, or Ang2 mRNA level alone (P＜0.05). The reproductive system infection, endocrine abnormalities, autoimmune diseases, high expression levels of CD81 mRNA, Ang1 mRNA, and Ang2 mRNA in placental villi of the women with RSA were the risk factors of their spontaneous abortion again. Conclusion: The occurrence of re-miscarriage of the women with RSA and spontaneous abortion again during the first trimester of pregnancy is related to their high mRNA expressions levels of CD81, Ang1, and Ang2. The detections of the mRNA levels of CD81, Ang1, and Ang2 of the women can evaluate the occurrence of their spontaneous abortion again to a certain extent.
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