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| Clinical values of the level of serum soluble vascular endothelial growth factor receptor-1 and the values of the arterial blood flow parameters by ultrasound for predicting the preeclampsia of pregnant women |
| Xuancheng City People's Hospital, Anhui Province, 242000 |
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Abstract To investigate the clinical values of the level of serum soluble vascular endothelial growth factor receptor-1 (sflt-1) and the values of the arterial blood flow parameters by ultrasound, such as resistance index (RI), pulsatility index (PI), and systolic to diastolic peak velocity ratio (S/D) for predicting the preeclampsia (PE) of pregnant women. Methods: 106 pregnant women with high-risk factors of PE were enrolled as the research objects. The peripheral venous blood of these women was collected from 16 to 20 gestational weeks for detecting the level of their serum sflt-1 by enzyme-linked immunosorbent assay (ELISA). The uterine artery blood flow parameters of these women during 20-24 gestational weeks were measured by Doppler ultrasound. 48 women with confirmed PE were included in study group, and 58 women with normal blood pressure were included in control group. The serum sflt-1 level and the values of arterial blood flow parameters by ultrasound of the women were compared between the two groups. Receiver operator characteristic (ROC) curve was drawn to analyze the value of the serum sflt-1 level and the values of arterial blood flow parameters of the women for predicting their PE. Results: The values of systolic blood pressure (SBP) and diastolic blood pressure (DBP), and the levels of blood albumin and blood nitrogen of the women at diagnosis in the study group were significantly higher than those of the women in the control group, and the placental mass and the birth weight of newborns in the study group were significantly lower than those of the women in the control group (P＜0.05). The serum sflt-1 level (27.15±3.78 mg/L), and the values of RI (0.92±0.18), PI (1.52±0.21), and S/D (4.16±1.11) of the women in the study group were significantly higher than those (5.49±1.14mg/L, 0.73±0.16, 1.01±0.18, and 3.63±0.79) of the women in the group (P＜0.05). ROC analysis showed that the value of the serum sflt-1 levels of the women for predicting their PE was similar to that of the values of RI and PI, and the value of S/D of the women for predicting their PE was the lowest. The value of the combined RI, PI, and S/D values of the women for predicting their PE was significantly higher than that of RI value, PI value, or S/D value alone, and the area under the curve (AUC) of which was 0.856. The predictive efficacy of the combination of the serum sflt-1 level and the values of RI, PI, and S/D of the women for their PE was the highest (AUC=0.920). Conclusion: The serum sflt1 level and the values of uterine artery blood flow parameters PI, RI and S/D by color ultrasound Doppler of the pregnant women with PE increase abnormally. The predictive efficacy of the combination of the serum sflt-1 level and the values of RI, PI, and S/D of the women for their PE is high, and which can be used as the reference indexes for clinical screening or predicting PE of the women.
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