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| Risk factors of nephrotic syndrome of pregnancy of women and their values for screening nephrotic syndrome occurrence in clinic and predicting the pregnancy outcomes of these women |
| 1. The First People's Hospital of Hangzhou, Hangzhou, Zhejiang Province, 310006; 2. Zhejiang Maternal and Child Health Center, Hangzhou |
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Abstract To explore the influence factors of nephrotic syndrome of pregnancy (NSP) of women during pregnancy, and to study their efficiency for screening NSP in clinic and predicting the pregnancy outcomes of these women. Methods: From January 2018 to January 2022, the clinical data of 39 pregnant women with NSP (in study group) and 54 pregnant women with pregnancy-induced hypertensive severe preeclampsia and without NSP (in control group) were selected in this study. The baseline data, the blood pressure values, the laboratory indexes levels of the women in the two groups were collected and were comparison analyzed. Multivariable logistic regression model was used to analyze the risk factors of NSP. According to the situation of neonatal asphyxia, these women were divided into group A (women with adverse pregnancy outcomes) and group B (women with normal pregnancy outcomes), and the differences of the risk factors indicators of the women were compared between group A and group B. Receiver operating characteristic (ROC) curve was drawn to analyze the values of the risk factors for screening NSP in clinic and diagnosing the adverse pregnancy outcomes of these women. Results: The systolic blood pressure (SBP) value, and the levels of fasting blood glucose (FBG), homocystatin C (CysC), total cholesterol (TC), triglyceride (TG), and urea nitrogen (BUN) of the women in the study group were significantly higher than those of the women in the control group, while the homocysteine (Hcy), plasma total protein (TPP) and albumin (Alb) levels of the women in the study group were significantly lower than those of the women in the control group (P＜0.05). The risk factors of NSP of the women were SBP, FBG and CysC, and the protective factors of NSP of the women were Alb and TPP (P＜0.05). The area under curve (AUC) of the level of SBP, FBG, Alb, CysC, or TTP for screening of NSP in clinic was > 0.75, and the sensitivity or the specificity of which was > 70.0%. The SBP value and the FBG level of the women in group A were significantly higher than those of the women in group B (P＜0.05). The AUC level of the SBP value and the FBG level for predicting the adverse pregnancy outcomes of the women were 0.800 and 0.814, the sensitivity of which were 73.3% and 86.3%, and the specificity of which were 77.0% and 80.0%. Conclusion: The SBP value, and the levels of FBG, CysC, Hcy, Alb, and TPP of the pregnant women with NSP are abnormal. The SBP value, and the levels of FBG, CysC, Alb, TPP of the women are all the influencing factors of NSP occurrence, and all of which can be used as the sensitive indicators for clinical screening NSP of these women. The SBP value and the FBG level can be used as the sensitive indicators for predicting the neonatal asphyxia of the women with NSP.
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