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Abstract To analyze the value of three-dimensional hysterosalpingo-contrast sonography (3D-HyCoSy) combined with saline-infused sonohysterography (SIS) for diagnosing intrauterine adhesion (IUA) of patients with infertility. Methods: The clinical data of 90 patients with infertility were collected retrospectively. All these patients had undergone 3D-HyCoSy and SIS. The results of hysteroscopy as the golden standard, the efficacy of 3D-HyCoSy or SIS alone, and the combined 3D-HyCoSy and SIS for diasgnosing IUA of these patients. Results: The pathological diagnosis after hysteroscopy showed that there were 41 (45.6%) patients with IUA. The sensitivity, the specificity, the accuracy, and the Kappa value of 3D-HyCoSy for diagnosing IUA of the patients were 73.2%, 77.6%, 75.6%, and 0.51, respectively, and which of SIS for diagnosing IUA of the patients were 80.5%, 75.5%, 77.8%, and 0.56, respectively. The sensitivity, the specificity, the accuracy, and the Kappa value of 3D-HyCoSy combined with SIS for diagnosing IUA of the patients were 95.1%, 89.8%, 92.2%, and 0.84, respectively. The sensitivity and the accuracy of 3D-HyCoSy combined with SIS for diagnosing IUA of the patients had increased (P＜0.05), but the specificity of which had no changed (P＞0.05). Conclusion: 3D-HyCoSy combined with SIS can effectively improves the accuracy rate of diagnosing IUA of the infertility patients, and which has non-invasive, no radiation, high application safety, so it has some clinical application value.
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