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| Levels of serum angiopoietin-like protein 2 and disintegrin-metalloproteinase 10 of pregnant women with hypertensive disorder complicating pregnancy and their correlation with the severity and prognosis of hypertensive disorder complicating pregnancy |
| Cangzhou People's Hospital, Cangzhou, Hubei Province, 061000 |
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Abstract To investigate the expression levels of serum angiopoietin-like protein 2 (ANGPTL2) and disintegrin-metalloproteinase 10 (ADAM10) of pregnant women with hypertensive disorder complicating pregnancy (HDCP), and to study their correlation with the severity and prognosis of HDCP. Methods: 106 pregnant women with HDCP from November 2019 to November 2021 were collected in group A, which included 28 cases with severe preeclampsia in group A1, 34 cases with moderate preeclampsia in group A2, and 44 cases with gestational hypertension in group A3. 100 healthy pregnant women were selected in group B during the same period. Enzyme-linked immunosorbent assay was used to detect the levels of serum ANGPTL2 and ADAM10 of the women. Spearman analysis was used to analyze the correlation between the severity of HDCP of the women and the levels of their serum ANGPTL2 and ADAM10, and their blood pressure value. According to the degree of amniotic fluid contamination and the neonatal Apgar score, the women in group A were divided group A4 (56 cases with poor prognosis) and group A5 (50 cases with normal prognosis). Multivariate logistic regression was used to analyze the factors affecting the prognosis of the women with HDCP. The predictive value of the levels of serum ANGPTL2 and ADAM10 of the women with HDCP for their prognosis was analyzed by receiver operating characteristic (ROC) curve. Results: The levels of ANGPTL2 (8.54±2.13 ng/ml) and ADAM10 (1700.54±300.35 pg/ml) of the women in group A were significantly higher than those (6.46±1.21 ng/ml and 1348.65±280.32 pg/ml) of the women in group B (all P＜0.05). The levels of serum ANGPTL2 and ADAM10, and the values of systolic blood pressure and diastolic blood pressure of the women in group A3, group A2, and group A1 had increased gradually, and which of the women were positively correlated with the severity of their HDCP. The value of 24h urinary protein (PRO), and the ANGPTL2 and ADAM10 levels of the women in group A4 were significantly higher than those of the women in group A5 (all P＜0.05). The abnormal high 24h PRO value and the high expressions of ANGPTL2 and ADAM10 of the women with HDCP were their factors influencing poor prognosis (all P＜0.05). The area under the curve (AUC) of the serum ANGPTL2 level for predicting the prognosis of the women with HDCP was 0.838, and the optimal critical value of which was 8.14 ng/ml. The AUC of the serum ADAM10 for predicting the prognosis of the women with HDCP was 0.834, and the optimal cut-off value of which was 1627.11 pg/ml. The AUC of the combined levels of serum ADAM10 and ANGPTL2 for predicting the prognosis of the women with HDCP was 0.921, and the predictive efficacy which was significantly higher than that of the serum ADAM10 level or ANGPTL2 level alone (all P＜0.05). Conclusion: The expressions of serum ANGPTL2 and ADAM10 of the women with HDCP are up-regulated, and are closely related to the severity and the prognosis of HDCP, and both of which can predicte the prognosis of HDCP of the women.
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